SLC36A2

Functionⁱ

Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

amino acid:proton symporter activity Source: GO_Central
amino acid transmembrane transporter activity Source: Reactome
glycine transmembrane transporter activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19033659
L-alanine transmembrane transporter activity Source: GO_Central
L-proline transmembrane transporter activity Source: GO_Central
proton transmembrane transporter activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amino acid transport Source: Reactome
ion transport Source: Reactome
proline transmembrane transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19033659

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Amino-acid transport, Transport

Biological process

Amino-acid transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-428559 Proton-coupled neutral amino acid transporters R-HSA-5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)

Reactomeⁱ

R-HSA-352230 Amino acid transport across the plasma membrane
R-HSA-428559 Proton-coupled neutral amino acid transporters
R-HSA-5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)

Protein family/group databases

TCDBⁱ	2.A.18.8.6 the amino acid/auxin permease (aaap) family

TCDBⁱ

2.A.18.8.6 the amino acid/auxin permease (aaap) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Proton-coupled amino acid transporter 2 Short name: Proton/amino acid transporter 2 Alternative name(s): Solute carrier family 36 member 2 Tramdorin-1
Gene namesⁱ	Name:SLC36A2 Synonyms:PAT2, TRAMD1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186335.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18762 SLC36A2
MIMⁱ	608331 gene
neXtProtⁱ	NX_Q495M3

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 58	CytoplasmicSequence analysisAdd BLAST	58
Transmembraneⁱ	59 – 79	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	80 – 81	ExtracellularSequence analysis	2
Transmembraneⁱ	82 – 102	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	103 – 148	CytoplasmicSequence analysisAdd BLAST	46
Transmembraneⁱ	149 – 169	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	170 – 197	ExtracellularSequence analysisAdd BLAST	28
Transmembraneⁱ	198 – 218	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	219 – 222	CytoplasmicSequence analysis	4
Transmembraneⁱ	223 – 243	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	244 – 264	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	265 – 285	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	286 – 296	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	297 – 317	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	318 – 349	ExtracellularSequence analysisAdd BLAST	32
Transmembraneⁱ	350 – 370	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	371 – 379	CytoplasmicSequence analysis	9
Transmembraneⁱ	380 – 400	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	401 – 404	ExtracellularSequence analysis	4
Transmembraneⁱ	405 – 425	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	426 – 437	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	438 – 458	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	459 – 483	ExtracellularSequence analysisAdd BLAST	25

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hyperglycinuria (HG)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones.

Iminoglycinuria (IG)1 Publication

The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Mutations in SLC36A2 that retain residual transport activity result in the IG phenotype only when combined with haploinsufficiency of the imino acid transporter SLC6A20 or deficiency of the neutral amino acid transporter SLC6A19. Additional polymorphisms and mutations in SLC6A18 can contribute to iminoglycinuria in some families.

Disease descriptionA disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	153201
MalaCards human disease database More...MalaCardsⁱ	SLC36A2
MIMⁱ	138500 phenotype 242600 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000186335
Orphanetⁱ	42062 Iminoglycinuria
PharmGKBⁱ	PA134899820

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00260 Cycloserine
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1162

Polymorphism and mutation databases

BioMutaⁱ	SLC36A2
DMDMⁱ	121943282

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000324819	1 – 483	Proton-coupled amino acid transporter 2Add BLAST		483

Proteomic databases

PaxDbⁱ	Q495M3
PeptideAtlas More...PeptideAtlasⁱ	Q495M3
PRIDEⁱ	Q495M3
ProteomicsDBⁱ	61963 61964 [Q495M3-2] 61965 [Q495M3-3]

PTM databases

iPTMnetⁱ	Q495M3
PhosphoSitePlusⁱ	Q495M3

Expressionⁱ

Tissue specificityⁱ

Abundantly expressed in kidney and muscle. Expressed in the S1 segment of the proximal tubule close to the glomerulus.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000186335 Expressed in 39 organ(s), highest expression level in muscle of leg
CleanExⁱ	HS_SLC36A2
ExpressionAtlasⁱ	Q495M3 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044002 HPA062229

HPAⁱ

HPA044002
HPA062229

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q495M3, 1 interactor
STRINGⁱ	9606.ENSP00000334223

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q495M3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the amino acid/polyamine transporter 2 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1304 Eukaryota COG0814 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011245
HOGENOMⁱ	HOG000006823
HOVERGENⁱ	HBG057183
InParanoidⁱ	Q495M3
KEGG Orthology (KO) More...KOⁱ	K14209
OMAⁱ	VGILCTY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G079T
PhylomeDBⁱ	Q495M3
TreeFamⁱ	TF314873

Family and domain databases

InterProⁱ	View protein in InterPro IPR013057 AA_transpt_TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01490 Aa_trans, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q495M3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVTKSTEGP QGAVAIKLDL MSPPESAKKL ENKDSTFLDE SPSESAGLKK 
        60         70         80         90        100
TKGITVFQAL IHLVKGNMGT GILGLPLAVK NAGILMGPLS LLVMGFIACH 
       110        120        130        140        150
CMHILVKCAQ RFCKRLNKPF MDYGDTVMHG LEANPNAWLQ NHAHWGRHIV 
       160        170        180        190        200
SFFLIITQLG FCCVYIVFLA DNLKQVVEAV NSTTNNCYSN ETVILTPTMD 
       210        220        230        240        250
SRLYMLSFLP FLVLLVLIRN LRILTIFSML ANISMLVSLV IIIQYITQEI 
       260        270        280        290        300
PDPSRLPLVA SWKTYPLFFG TAIFSFESIG VVLPLENKMK NARHFPAILS 
       310        320        330        340        350
LGMSIVTSLY IGMAALGYLR FGDDIKASIS LNLPNCWLYQ SVKLLYIAGI 
       360        370        380        390        400
LCTYALQFYV PAEIIIPFAI SRVSTRWALP LDLSIRLVMV CLTCLLAILI 
       410        420        430        440        450
PRLDLVISLV GSVSGTALAL IIPPLLEVTT FYSEGMSPLT IFKDALISIL 
       460        470        480 
GFVGFVVGTY QALDELLKSE DSHPFSNSTT FVR

Length:483

Mass (Da):53,216

Last modified:September 13, 2005 - v1

Checksum:ⁱE283B8C6F0C63666

GO

Isoform 2 (identifier: Q495M3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-198: Missing.

« Hide

        10         20         30         40         50
MDSRLYMLSF LPFLVLLVLI RNLRILTIFS MLANISMLVS LVIIIQYITQ 
        60         70         80         90        100
EIPDPSRLPL VASWKTYPLF FGTAIFSFES IGVVLPLENK MKNARHFPAI 
       110        120        130        140        150
LSLGMSIVTS LYIGMAALGY LRFGDDIKAS ISLNLPNCWL YQSVKLLYIA 
       160        170        180        190        200
GILCTYALQF YVPAEIIIPF AISRVSTRWA LPLDLSIRLV MVCLTCLLAI 
       210        220        230        240        250
LIPRLDLVIS LVGSVSGTAL ALIIPPLLEV TTFYSEGMSP LTIFKDALIS 
       260        270        280 
ILGFVGFVVG TYQALDELLK SEDSHPFSNS TTFVR

Note: No experimental confirmation available.

Show »

Length:285

Mass (Da):31,642

Checksum:ⁱEA3F89C90602A4CE

GO

Isoform 3 (identifier: Q495M3-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-276: Missing.
277-281: ESIGV → MNDTA

« Hide

        10         20         30         40         50
MNDTAVLPLE NKMKNARHFP AILSLGMSIV TSLYIGMAAL GYLRFGDDIK 
        60         70         80         90        100
ASISLNLPNC WLYQSVKLLY IAGILCTYAL QFYVPAEIII PFAISRVSTR 
       110        120        130        140        150
WALPLDLSIR LVMVCLTCLL AILIPRLDLV ISLVGSVSGT ALALIIPPLL 
       160        170        180        190        200
EVTTFYSEGM SPLTIFKDAL ISILGFVGFV VGTYQALDEL LKSEDSHPFS 

NSTTFVR

Note: No experimental confirmation available.

Show »

Length:207

Mass (Da):22,680

Checksum:ⁱ6320177505ED6D96

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RJJ5	E5RJJ5_HUMAN	Proton-coupled amino acid transport... Proton-coupled amino acid transporter 2	SLC36A2	395	Annotation score:
H0YB43	H0YB43_HUMAN	Proton-coupled amino acid transport... Proton-coupled amino acid transporter 2	SLC36A2	107	Annotation score:
E5RGH8	E5RGH8_HUMAN	Proton-coupled amino acid transport... Proton-coupled amino acid transporter 2	SLC36A2	147	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	156	I → N in AAO11788 (PubMed:12809675).Curated	1
Sequence conflictⁱ	408	S → P in AAO11788 (PubMed:12809675).Curated	1
Sequence conflictⁱ	410	V → M in BAC85496 (PubMed:14702039).Curated	1
Sequence conflictⁱ	429	T → P in BAC85496 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_064795	87	G → V in HG and IG; partially inactivating mutation; results in a 3-fold increase of Km value for proline and a 5-fold increase of Km for glycine. 1 PublicationCorresponds to variant dbSNP:rs77010315EnsemblClinVar.		1
Natural variantⁱVAR_039887	445	A → V. Corresponds to variant dbSNP:rs10042608Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_032371	1 – 276	Missing in isoform 3. 1 PublicationAdd BLAST	276
Alternative sequenceⁱVSP_032372	1 – 198	Missing in isoform 2. 1 PublicationAdd BLAST	198
Alternative sequenceⁱVSP_032373	277 – 281	ESIGV → MNDTA in isoform 3. 1 Publication	5

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY162214 mRNA Translation: AAO11788.1 AK122630 mRNA Translation: BAC85496.1 CH471062 Genomic DNA Translation: EAW61678.1 BC101100 mRNA Translation: AAI01101.1 BC101101 mRNA Translation: AAI01102.1 BC101102 mRNA Translation: AAI01103.1 BC101103 mRNA Translation: AAI01104.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4315.1 [Q495M3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_861441.2, NM_181776.2 [Q495M3-1] XP_016864573.1, XM_017009084.1 [Q495M3-2]
UniGeneⁱ	Hs.483877

Genome annotation databases

Ensemblⁱ	ENST00000335244; ENSP00000334223; ENSG00000186335 [Q495M3-1]
GeneIDⁱ	153201
KEGGⁱ	hsa:153201
UCSC genome browser More...UCSCⁱ	uc003lty.3 human [Q495M3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q495M3	Isoform 2 of Proton-coupled amino acid transporter 2		HUMAN		285	UniRef100_Q495M3
UPI000166C69D		HUMAN		393

Protein	Similar proteins		Species	Score	Length	Source
Q495M3	Isoform 2 of Proton-coupled amino acid transporter 2		HUMAN		285	UniRef90_Q495M3
Uncharacterized protein		PONAB		483
Uncharacterized protein		Cebus capucinus imitator		483
SLC36A2 isoform 1		PANTR		483
Uncharacterized protein		AOTNA		483
+24

Protein	Similar proteins		Species	Score	Length	Source
Q495M3	Proton-coupled amino acid transporter 2		MOUSE		478	UniRef50_Q8BHK3
Proton-coupled amino acid transporter 2		RAT		481
Proton-coupled amino acid transporter 1		HUMAN		476
proton-coupled amino acid transporter 2		MESAU		481
Proton-coupled amino acid transporter 2		CRIGR		480
+660
Q495M3-3	Uncharacterized protein (Fragment)		Micrurus lemniscatus lemniscatus		169	UniRef50_Q495M3-3
UPI0004F03C2C		MERNU		169

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY162214 mRNA Translation: AAO11788.1 AK122630 mRNA Translation: BAC85496.1 CH471062 Genomic DNA Translation: EAW61678.1 BC101100 mRNA Translation: AAI01101.1 BC101101 mRNA Translation: AAI01102.1 BC101102 mRNA Translation: AAI01103.1 BC101103 mRNA Translation: AAI01104.1
CCDSⁱ	CCDS4315.1 [Q495M3-1]
RefSeqⁱ	NP_861441.2, NM_181776.2 [Q495M3-1] XP_016864573.1, XM_017009084.1 [Q495M3-2]
UniGeneⁱ	Hs.483877

3D structure databases

ProteinModelPortalⁱ	Q495M3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q495M3, 1 interactor
STRINGⁱ	9606.ENSP00000334223

Chemistry databases

DrugBankⁱ	DB00260 Cycloserine
GuidetoPHARMACOLOGYⁱ	1162

Protein family/group databases

TCDBⁱ	2.A.18.8.6 the amino acid/auxin permease (aaap) family

TCDBⁱ

2.A.18.8.6 the amino acid/auxin permease (aaap) family

PTM databases

iPTMnetⁱ	Q495M3
PhosphoSitePlusⁱ	Q495M3

Polymorphism and mutation databases

BioMutaⁱ	SLC36A2
DMDMⁱ	121943282

Proteomic databases

PaxDbⁱ	Q495M3
PeptideAtlasⁱ	Q495M3
PRIDEⁱ	Q495M3
ProteomicsDBⁱ	61963 61964 [Q495M3-2] 61965 [Q495M3-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000335244; ENSP00000334223; ENSG00000186335 [Q495M3-1]
GeneIDⁱ	153201
KEGGⁱ	hsa:153201
UCSCⁱ	uc003lty.3 human [Q495M3-1]

Organism-specific databases

CTDⁱ	153201
DisGeNETⁱ	153201
EuPathDBⁱ	HostDB:ENSG00000186335.8
GeneCardsⁱ	SLC36A2
HGNCⁱ	HGNC:18762 SLC36A2
HPAⁱ	HPA044002 HPA062229
MalaCardsⁱ	SLC36A2
MIMⁱ	138500 phenotype 242600 phenotype 608331 gene
neXtProtⁱ	NX_Q495M3
OpenTargetsⁱ	ENSG00000186335
Orphanetⁱ	42062 Iminoglycinuria
PharmGKBⁱ	PA134899820
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1304 Eukaryota COG0814 LUCA
GeneTreeⁱ	ENSGT00390000011245
HOGENOMⁱ	HOG000006823
HOVERGENⁱ	HBG057183
InParanoidⁱ	Q495M3
KOⁱ	K14209
OMAⁱ	VGILCTY
OrthoDBⁱ	EOG091G079T
PhylomeDBⁱ	Q495M3
TreeFamⁱ	TF314873

Enzyme and pathway databases

Reactomeⁱ	R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-428559 Proton-coupled neutral amino acid transporters R-HSA-5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)

Reactomeⁱ

R-HSA-352230 Amino acid transport across the plasma membrane
R-HSA-428559 Proton-coupled neutral amino acid transporters
R-HSA-5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)

Miscellaneous databases

ChiTaRSⁱ	SLC36A2 human
GeneWikiⁱ	SLC36A2
GenomeRNAiⁱ	153201
Protein Ontology More...PROⁱ	PR:Q495M3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186335 Expressed in 39 organ(s), highest expression level in muscle of leg
CleanExⁱ	HS_SLC36A2
ExpressionAtlasⁱ	Q495M3 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR013057 AA_transpt_TM
Pfamⁱ	View protein in Pfam PF01490 Aa_trans, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S36A2_HUMAN
Accessionⁱ	Q495M3Primary (citable) accession number: Q495M3 Secondary accession number(s): Q495M4 , Q495M6, Q6ZWK5, Q7Z6B5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	September 13, 2005
	Last modified:	September 12, 2018
	This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q495M3 (S36A2_HUMAN)

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Proton-coupled amino acid transporter 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ