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Entry version 92 (11 Dec 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Cytadherence high molecular weight protein 1

Gene

hmw1

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less Mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCytadherence, Virulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MGEN243273:G1GJ2-381-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytadherence high molecular weight protein 1
Alternative name(s):
Cytadherence accessory protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hmw1
Ordered Locus Names:MG312
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243273 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000807 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000840111 – 1139Cytadherence high molecular weight protein 1Add BLAST1139

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q49413

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
243273.MG_312

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili902 – 935Sequence analysisAdd BLAST34
Coiled coili974 – 1025Sequence analysisAdd BLAST52

Keywords - Domaini

Coiled coil

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

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OMAi
PTDENYG

Database of Orthologous Groups

More...
OrthoDBi
2073552at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1660.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022466 AGR_box
IPR021199 Cytadherence_HMW-1_N
IPR038145 EAGR_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16713 EAGR_box, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03834 EAGR_box, 1 hit
TIGR03836 termin_org_HMW1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q49413-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKNKQSVFE EKNYTQTEPE NIFGDLYDGK STVEEDPNIK VAYDADGNGY
60 70 80 90 100
YIAFNKETGV YYDPYGDTEY DISQLFDENG NPFVFDEKQE ENDYLKYVGN
110 120 130 140 150
PDYGSYDENG EWVWSGYFEN DQWISTKESQ PTDENYGFDS DLPPEVKQPE
160 170 180 190 200
SVEDNYGFDN DLPPEVKQPE SVEDNYGFDN DLPPEVKQPE SVVDQPSSDD
210 220 230 240 250
YFAKQPTDEN YGFDNDLPPE VKQPESVVDQ PSSDDHFAKQ PESTTDSYSF
260 270 280 290 300
DSDLPQPTLD QPSLDDHVQY NFDHHEELKP VAEEQNNYQV GFDQVQANLD
310 320 330 340 350
NNEEIQPTAE KKVTTDFESK QAQVVDSYQL PIDTDQQDQT TFSSSFETQP
360 370 380 390 400
TVEQFDQVNS EVNDQFKPEI TKEPVLESSF NKQDVVETSD LNSESNLYSE
410 420 430 440 450
NNKDATNNDS LNSEFIQLNS NSETASDDVH YESKSEPIHD YKFGSDLSQS
460 470 480 490 500
NSNNSLESEP VKFNSETAPD AHFESQSEPV DQVQYDIYQN EELKPTLDQP
510 520 530 540 550
SSDDYFAKQP TDENYGFDND LPPEVKQPES VVDQPSSDDH FAKQPESTTD
560 570 580 590 600
SYSFDSDLPQ PTLDQPSLDD HVQYNFDHHE ELKPVAEEQN NYQVGFDQVQ
610 620 630 640 650
ANLDNNEEIQ PTAEKEVTTD FESKQAQVVD SYQLPIDTDQ QDQTTFSSSF
660 670 680 690 700
ETQPTVEQFD QVNSEVNDQF KPEITKEPVL ESSFNKQDVV ETSNYTNNLQ
710 720 730 740 750
KFDIQSDNKI TITTKKSSPQ IPTTLPISFV SNRIEYKPVE TLALDNKESQ
760 770 780 790 800
QEQITINSIT EDSKTLAKTL SVQLQQINSL NNQSIVTSES VRLDKKDDQL
810 820 830 840 850
TINTVNSEDQ QPKIEVFVKA KEPVEEHSIT QNKQSVEDKS ELDNFNKKSD
860 870 880 890 900
LYKIISELKR GELNPTINFD AIFQMNDYQM SVKQSFIHLN DFVTNYKNQI
910 920 930 940 950
SERYLIIKKE LQSELSRLID QNENLNVQFN NAKNLTTLQK EEMIRSLASD
960 970 980 990 1000
FAIAYKPSNS YEQLQKSGEI MRHVQRAITE NEKKIESIQG SLKQLKTVYN
1010 1020 1030 1040 1050
SCCETIMNNI NKLDNTLRFA KKEKDPLLLS NFDSVTDNGL VEPNQLMDDL
1060 1070 1080 1090 1100
IDFSNTFDNI SNEQLDDFIY ENMDRNIDFE FEGFNNDFVD IDAKVMDSMS
1110 1120 1130
AFSVNDLDIE TLVPDRTSNF SSLLDEDLFE SSGDFSLDY
Length:1,139
Mass (Da):130,531
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0011D3288C3DD856
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71534.1
U02261 Genomic DNA Translation: AAD12527.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E64234

NCBI Reference Sequences

More...
RefSeqi
WP_010869424.1, NC_000908.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC71534; AAC71534; MG_312

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mge:MG_312

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71534.1
U02261 Genomic DNA Translation: AAD12527.1
PIRiE64234
RefSeqiWP_010869424.1, NC_000908.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi243273.MG_312

Proteomic databases

PRIDEiQ49413

Genome annotation databases

EnsemblBacteriaiAAC71534; AAC71534; MG_312
KEGGimge:MG_312

Phylogenomic databases

OMAiPTDENYG
OrthoDBi2073552at2

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-381-MONOMER

Family and domain databases

Gene3Di1.10.1660.50, 1 hit
InterProiView protein in InterPro
IPR022466 AGR_box
IPR021199 Cytadherence_HMW-1_N
IPR038145 EAGR_sf
PfamiView protein in Pfam
PF16713 EAGR_box, 1 hit
TIGRFAMsiTIGR03834 EAGR_box, 1 hit
TIGR03836 termin_org_HMW1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMW1_MYCGE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q49413
Secondary accession number(s): Q49365
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: December 11, 2019
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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