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Entry version 93 (02 Jun 2021)
Sequence version 1 (13 Sep 2005)
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Protein
Submitted name:

Putative cell surface protein

Gene

M28_Spy1325

Organism
Streptococcus pyogenes serotype M28 (strain MGAS6180)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1029CalciumCombined sources1
Metal bindingi1084Calcium; via carbonyl oxygenCombined sources1
Metal bindingi1086Calcium; via carbonyl oxygenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumCombined sources, Metal-bindingCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Putative cell surface proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:M28_Spy1325Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pyogenes serotype M28 (strain MGAS6180)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri319701 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009292 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1328 – 1347HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell wallPROSITE-ProRule annotationARBA annotation, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...
PHI-basei
PHI:2880

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 39Sequence analysisAdd BLAST39
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500423497240 – 1352Sequence analysisAdd BLAST1313
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_50183538521324 – 1352Removed by sortasePROSITE-ProRule annotationAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1323Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchorPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q48S75

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1320 – 1352GRAM_POS_ANCHORINGInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni109 – 138DisorderedSequence analysisAdd BLAST30
Regioni164 – 183DisorderedSequence analysisAdd BLAST20
Regioni636 – 765DisorderedSequence analysisAdd BLAST130
Regioni946 – 972DisorderedSequence analysisAdd BLAST27
Regioni1298 – 1321DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili196 – 230Sequence analysisAdd BLAST35
Coiled coili235 – 308Sequence analysisAdd BLAST74
Coiled coili327 – 386Sequence analysisAdd BLAST60
Coiled coili391 – 457Sequence analysisAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1320 – 1324LPXTG sorting signalPROSITE-ProRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi636 – 657Basic and acidic residuesSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_257994_0_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
IDANNDY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026345, Adh_isopep-form_adh_dom
IPR041324, AgI/II_N
IPR032300, Antigen_C
IPR041237, BspA_v
IPR021197, Cross-wall-target_lipo_motif
IPR019948, Gram-positive_anchor
IPR019931, LPXTG_anchor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18652, Adhesin_P1_N, 1 hit
PF17998, AgI_II_C2, 1 hit
PF16364, Antigen_C, 1 hit
PF18220, BspA_v, 1 hit
PF00746, Gram_pos_anchor, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04228, isopep_sspB_C2, 1 hit
TIGR03726, strep_RK_lipo, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50847, GRAM_POS_ANCHORING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q48S75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQMETKGYG YFRKTKAYGL VCGITLAGAL TLGTTSVSAD DVTTLNPATN
60 70 80 90 100
LTTLQTPPTA DQTQLAHQAG QQSGELVSEV SNTEWDNAVT TAQKAGVTVK
110 120 130 140 150
QSEKVTHDSL SSAQADLEKQ TQAVTEATTK QEANTTAINQ AVSENKAIDQ
160 170 180 190 200
ANRDEKARVD ALNTKGEADT KAKNETGQAQ VDAQNKQAQA AADAMNAKLK
210 220 230 240 250
ADYEAKLTEI KQIESENEAI RQRNQQASQA THQANQAAQA AYQEKLAEIE
260 270 280 290 300
RIKAENAAIR DRNAKAQQEA ERQNQALQAA YEAKLAEIKQ IESENAAIRQ
310 320 330 340 350
RNEQAGQATN QTNQAAQAAY QEKLAEIERI KAGNAAIRDR NAKAQQEAER
360 370 380 390 400
QNQALQAAYE AKLAEIKQIE SENAAIRKRN EQAGQTTNQT NQAAQAAYQE
410 420 430 440 450
KLAEIERINA ENAAIRDRNT KARQEAERQN QQLKTTYEAQ LSAYQQALQA
460 470 480 490 500
KKEAENKAID QVVFGIDAKA NGVDNAEYGN SIMTVTTQPD GSFVFKHDMI
510 520 530 540 550
DGVKTIGHGT LTGKINHHYE ANKDGSITAY IDSVTFDKYE YQNVAKNDAV
560 570 580 590 600
DKNIAFRILS ATGQELFVKA HDGDKTFSET LNKTVSLKLT YQLKPHEAVK
610 620 630 640 650
DIKVFQLHDD WVHDTHGSAL VSYVNNNDAV PHIEVPEKPV EPDMVTPKVE
660 670 680 690 700
QEKPVPEAPQ KPTDGVPNLE KEKPVPPTPV KPEAVKPVLE QEKPVPEAPQ
710 720 730 740 750
KPTDDVPNLE KEKPVPPTPV KPEAVKPVLE QEKPVPEAPQ KPTDDVPNLE
760 770 780 790 800
KEKPVPPTPV EPEAIKPDLQ SFTPEVYDPI KPVVKPHVTV PEKVVYEVMV
810 820 830 840 850
HPVQVKQTPT NVKSVTNSDQ VNIDGQLVPK GSTVTWELVN TSLKAGRQDI
860 870 880 890 900
TSYELTDPLP DGFELDVTAT QTLSPEWVIT TDEAGKVSLK ASQSLLAHFN
910 920 930 940 950
AKRDQDVEVP KVSLVGRLLN DAGTYHNTFK TVVTTPTGSY TVISNTPVIY
960 970 980 990 1000
TPGNDPKTPR NPGGDNPTPH DNLIQPTKTI VDDKGQSIDG KSVLPNSTLT
1010 1020 1030 1040 1050
YVAKQDFDQY KGMTAAKESV MKGFIYVDDY KDEAIDGHSL VVNSIKAANG
1060 1070 1080 1090 1100
DDVTNLLEMR HVLSQDTLDD KLKALIKASG ISPVGEFYMW VAKDPAAFYK
1110 1120 1130 1140 1150
AYVQKGLDIT YNLSFKLKQD FKKGDITNQT YQIDFGNGYY GNIVVNHLSE
1160 1170 1180 1190 1200
LTVHKDVFDK EGGQSINAGT VKVGDEVTYR LEGWVVPTNR GYDLTEYKFV
1210 1220 1230 1240 1250
DQLQHTHDLY QKDKVLATVD ITLSDGSVIT KGTDLAKYTE TVYNKETGHY
1260 1270 1280 1290 1300
ELAFKQDFLA KVVRSSEFGA DAFVVVKRIK AGDVANEYTL YVNGNPVKSN
1310 1320 1330 1340 1350
KVTTHTPEQP QPVTPKAPAL PSTGEQGVSI LTALGAALLS LLGYVGLKKR

QQ
Length:1,352
Mass (Da):148,360
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBB696B2AEAD2391
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000056 Genomic DNA Translation: AAX72435.1

NCBI Reference Sequences

More...
RefSeqi
WP_011285012.1, NC_007296.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAX72435; AAX72435; M28_Spy1325

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spb:M28_Spy1325

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000056 Genomic DNA Translation: AAX72435.1
RefSeqiWP_011285012.1, NC_007296.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OFQX-ray1.80A/B971-1307[»]
SMRiQ48S75
ModBaseiSearch...
PDBe-KBiSearch...

Genome annotation databases

EnsemblBacteriaiAAX72435; AAX72435; M28_Spy1325
KEGGispb:M28_Spy1325

Phylogenomic databases

HOGENOMiCLU_257994_0_0_9
OMAiIDANNDY

Miscellaneous databases

PHI-baseiPHI:2880

Family and domain databases

InterProiView protein in InterPro
IPR026345, Adh_isopep-form_adh_dom
IPR041324, AgI/II_N
IPR032300, Antigen_C
IPR041237, BspA_v
IPR021197, Cross-wall-target_lipo_motif
IPR019948, Gram-positive_anchor
IPR019931, LPXTG_anchor
PfamiView protein in Pfam
PF18652, Adhesin_P1_N, 1 hit
PF17998, AgI_II_C2, 1 hit
PF16364, Antigen_C, 1 hit
PF18220, BspA_v, 1 hit
PF00746, Gram_pos_anchor, 1 hit
TIGRFAMsiTIGR04228, isopep_sspB_C2, 1 hit
TIGR03726, strep_RK_lipo, 1 hit
PROSITEiView protein in PROSITE
PS50847, GRAM_POS_ANCHORING, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ48S75_STRPM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q48S75
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: June 2, 2021
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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