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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei197UniRule annotation1
Active sitei224UniRule annotation1
Active sitei321UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Enzyme and pathway databases

BioCyciCPSY167879:G1G4N-1384-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:CPS_1523
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
Proteomesi
  • UP000000547 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002254541 – 379Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ485K0

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_1523

Structurei

3D structure databases

ProteinModelPortaliQ485K0
SMRiQ485K0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini185 – 379CheB-type methylesteraseUniRule annotationAdd BLAST195

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP Bacteria
COG2201 LUCA
HOGENOMiHOG000151424
KOiK03412
OMAiYGMPMAV
OrthoDBiPOG091H045J

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q485K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYKVLVVDD SSFFRRRVTD ILNKDPKLNV IDVAVNGQEA VDKALLLKPD
60 70 80 90 100
VITMDIEMPI LNGIEAVRKI MAQSPTSILM FSSLTHQGAK ATLEALDAGA
110 120 130 140 150
LDFLPKKFSE IAKNSDEAGS LLRQRVVEIA RKSEFSKQRT RTRPAAVNIS
160 170 180 190 200
PKSSRLIADQ HRPLASTSSL VTKDKKVMAA ITRSSGKEYK LLAIGTSTGG
210 220 230 240 250
PVALQKILVQ LEENFPLPII IVQHMPAAFT AAFASRLNSL CKISIKEAAD
260 270 280 290 300
GDVLKPGCAY LAPGGRQMLI SGSENSAKIK ILDDDSPKIT FKPSVDISFG
310 320 330 340 350
SAAKTFAGKV LGVILTGMGS DGKEGARMLK AKGATIWSQD EQSCVVYGMP
360 370
QAIDKAGISE LSLSLDSMAA SMVKEISRG
Length:379
Mass (Da):40,593
Last modified:September 13, 2005 - v1
Checksum:i212512B6C14FA440
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA Translation: AAZ25939.1
RefSeqiWP_011042359.1, NC_003910.7

Genome annotation databases

EnsemblBacteriaiAAZ25939; AAZ25939; CPS_1523
KEGGicps:CPS_1523

Similar proteinsi

Entry informationi

Entry nameiCHEB_COLP3
AccessioniPrimary (citable) accession number: Q485K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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