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Protein

Outer membrane protein C

Gene

ompC

Organism
Klebsiella pneumoniae
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms pores that allow passive diffusion of small molecules across the outer membrane. In K.pneumoniae it has been shown to bind the C1Q component and activate the classical pathway of the complement system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPorin
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein C
Alternative name(s):
Porin OmpC
Porin ompk36
Gene namesi
Name:ompC
Synonyms:ompK36
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000002523622 – 363Outer membrane protein CAdd BLAST342

Proteomic databases

PRIDEiQ48473

Interactioni

Subunit structurei

Homotrimer.

Structurei

Secondary structure

1363
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ48473
SMRiQ48473
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ48473

Family & Domainsi

Sequence similaritiesi

Belongs to the Gram-negative porin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001897 Porin_gammaproteobac
IPR001702 Porin_Gram-ve
IPR013793 Porin_Gram-ve_CS
PfamiView protein in Pfam
PF00267 Porin_1, 1 hit
PRINTSiPR00183 ECOLIPORIN
PR00182 ECOLNEIPORIN
PROSITEiView protein in PROSITE
PS00576 GRAM_NEG_PORIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q48473-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVKVLSLLV PALLVAGAAN AAEIYNKDGN KLDLYGKIDG LHYFSDDKDV
60 70 80 90 100
DGDQTYMRLG VKGETQINDQ LTGYGQWEYN VQANNTESSS DQAWTRLAFA
110 120 130 140 150
GLKFGDAGSF DYGRNYGVVY DVTSWTDVLP EFGGDTYGSD NFLQSRANGV
160 170 180 190 200
ATYRNSDFFG LVDGLNFALQ YQGKNGSVSG EGATNNGRGA LKQNGDGFGT
210 220 230 240 250
SVTYDIFDGI SAGFAYANSK RTDDQNQLLL GEGDHAETYT GGLKYDANNI
260 270 280 290 300
YLATQYTQTY NATRAGSLGF ANKAQNFEVA AQYQFDFGLR PSVAYLQSKG
310 320 330 340 350
KDLNGYGDQD ILKYVDVGAT YYFNKNMSTY VDYKINLLDD NSFTRSAGIS
360
TDDVVALGLV YQF
Length:363
Mass (Da):39,663
Last modified:November 1, 1996 - v1
Checksum:i9DE45546F01F116C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33506 Genomic DNA Translation: CAA83913.1
PIRiS51104

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33506 Genomic DNA Translation: CAA83913.1
PIRiS51104

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OSMX-ray3.20A/B/C22-363[»]
ProteinModelPortaliQ48473
SMRiQ48473
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ48473

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ48473

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001897 Porin_gammaproteobac
IPR001702 Porin_Gram-ve
IPR013793 Porin_Gram-ve_CS
PfamiView protein in Pfam
PF00267 Porin_1, 1 hit
PRINTSiPR00183 ECOLIPORIN
PR00182 ECOLNEIPORIN
PROSITEiView protein in PROSITE
PS00576 GRAM_NEG_PORIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOMPC_KLEPN
AccessioniPrimary (citable) accession number: Q48473
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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