UniProtKB - Q48255 (AROQ_HELPY)
Protein
3-dehydroquinate dehydratase
Gene
aroQ
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Catalyzes a trans-dehydration via an enolate intermediate.By similarity
Catalytic activityi
- EC:4.2.1.10
: chorismate biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.Proteins known to be involved in the 7 steps of the subpathway in this organism are:
- no protein annotated in this organism
- 3-dehydroquinate synthase (aroB)
- 3-dehydroquinate dehydratase (aroQ)
- Shikimate dehydrogenase (NADP(+)) (aroE)
- Shikimate kinase (aroK)
- 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
- Chorismate synthase (aroC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 17 | Transition state stabilizer | 1 | |
Active sitei | 22 | Proton acceptor | 1 | |
Binding sitei | 76 | Substrate1 Publication | 1 | |
Binding sitei | 82 | Substrate1 Publication | 1 | |
Binding sitei | 89 | Substrate1 Publication | 1 | |
Active sitei | 102 | Proton donor | 1 | |
Binding sitei | 113 | Substrate1 Publication | 1 |
GO - Molecular functioni
- 3-dehydroquinate dehydratase activity Source: UniProtKB-UniRule
GO - Biological processi
- aromatic amino acid family biosynthetic process Source: UniProtKB-UniRule
- chorismate biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Lyase |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis |
Enzyme and pathway databases
BioCyci | HPY:HP1038-MONOMER |
BRENDAi | 4.2.1.10, 2604 |
UniPathwayi | UPA00053;UER00086 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-dehydroquinate dehydratase (EC:4.2.1.10)Short name: 3-dehydroquinase Alternative name(s): Type II DHQase |
Gene namesi | Name:aroQ Ordered Locus Names:HP_1038 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
Pathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL4680 |
DrugBanki | DB03868, 3-Dehydroquinic Acid DB04698, N-(1,4-dihydro-5H-tetrazol-5-ylidene)-9-oxo-9H-xanthene-2-sulfonamide |
DrugCentrali | Q48255 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000159905 | 1 – 167 | 3-dehydroquinate dehydrataseAdd BLAST | 167 |
Proteomic databases
PaxDbi | Q48255 |
Interactioni
Subunit structurei
Homododecamer.
2 PublicationsProtein-protein interaction databases
DIPi | DIP-3328N |
IntActi | Q48255, 2 interactors |
MINTi | Q48255 |
STRINGi | 85962.C694_05370 |
Chemistry databases
BindingDBi | Q48255 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q48255 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q48255 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 103 – 104 | Substrate binding | 2 |
Sequence similaritiesi
Belongs to the type-II 3-dehydroquinase family.Curated
Phylogenomic databases
eggNOGi | COG0757, Bacteria |
OMAi | AYTHYSY |
Family and domain databases
CDDi | cd00466, DHQase_II, 1 hit |
Gene3Di | 3.40.50.9100, 1 hit |
HAMAPi | MF_00169, AroQ, 1 hit |
InterProi | View protein in InterPro IPR001874, DHquinase_II IPR018509, DHquinase_II_CS IPR036441, DHquinase_II_sf |
PANTHERi | PTHR21272, PTHR21272, 1 hit |
Pfami | View protein in Pfam PF01220, DHquinase_II, 1 hit |
PIRSFi | PIRSF001399, DHquinase_II, 1 hit |
SUPFAMi | SSF52304, SSF52304, 1 hit |
TIGRFAMsi | TIGR01088, aroQ, 1 hit |
PROSITEi | View protein in PROSITE PS01029, DEHYDROQUINASE_II, 1 hit |
i Sequence
Sequence statusi: Complete.
Q48255-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKILVIQGPN LNMLGHRDPR LYGMVTLDQI HEIMQTFVKQ GNLDVELEFF
60 70 80 90 100
QTNFEGEIID KIQESVGSDY EGIIINPGAF SHTSIAIADA IMLAGKPVIE
110 120 130 140 150
VHLTNIQARE EFRKNSYTGA ACGGVIMGFG PLGYNMALMA MVNILAEMKA
160
FQEAQKNNPN NPINNQK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 156 | K → Q in CAA67380 (PubMed:8912695).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD08081.1 X98878 Genomic DNA Translation: CAA67380.1 |
PIRi | S72447 |
RefSeqi | NP_207828.1, NC_000915.1 WP_000699284.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD08081; AAD08081; HP_1038 |
KEGGi | hpy:HP1038 |
PATRICi | fig|85962.47.peg.1117 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD08081.1 X98878 Genomic DNA Translation: CAA67380.1 |
PIRi | S72447 |
RefSeqi | NP_207828.1, NC_000915.1 WP_000699284.1, NC_018939.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1J2Y | X-ray | 2.60 | A | 1-167 | [»] | |
2C4V | X-ray | 2.50 | A | 1-167 | [»] | |
2C4W | X-ray | 1.55 | A | 1-167 | [»] | |
2C57 | X-ray | 3.10 | A/B/C/D/E/F/G/H/I/J/K/L | 1-167 | [»] | |
2WKS | X-ray | 2.95 | A/B/C/D/E/F | 1-167 | [»] | |
2XB9 | X-ray | 2.75 | A/B/C | 1-167 | [»] | |
2XD9 | X-ray | 1.95 | A/B/C | 1-167 | [»] | |
2XDA | X-ray | 1.85 | A | 1-167 | [»] | |
4B6R | X-ray | 2.00 | A/B/C | 1-167 | [»] | |
4B6S | X-ray | 1.90 | A/B/C | 1-167 | [»] | |
SMRi | Q48255 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-3328N |
IntActi | Q48255, 2 interactors |
MINTi | Q48255 |
STRINGi | 85962.C694_05370 |
Chemistry databases
BindingDBi | Q48255 |
ChEMBLi | CHEMBL4680 |
DrugBanki | DB03868, 3-Dehydroquinic Acid DB04698, N-(1,4-dihydro-5H-tetrazol-5-ylidene)-9-oxo-9H-xanthene-2-sulfonamide |
DrugCentrali | Q48255 |
Proteomic databases
PaxDbi | Q48255 |
Genome annotation databases
EnsemblBacteriai | AAD08081; AAD08081; HP_1038 |
KEGGi | hpy:HP1038 |
PATRICi | fig|85962.47.peg.1117 |
Phylogenomic databases
eggNOGi | COG0757, Bacteria |
OMAi | AYTHYSY |
Enzyme and pathway databases
UniPathwayi | UPA00053;UER00086 |
BioCyci | HPY:HP1038-MONOMER |
BRENDAi | 4.2.1.10, 2604 |
Miscellaneous databases
EvolutionaryTracei | Q48255 |
PROi | PR:Q48255 |
Family and domain databases
CDDi | cd00466, DHQase_II, 1 hit |
Gene3Di | 3.40.50.9100, 1 hit |
HAMAPi | MF_00169, AroQ, 1 hit |
InterProi | View protein in InterPro IPR001874, DHquinase_II IPR018509, DHquinase_II_CS IPR036441, DHquinase_II_sf |
PANTHERi | PTHR21272, PTHR21272, 1 hit |
Pfami | View protein in Pfam PF01220, DHquinase_II, 1 hit |
PIRSFi | PIRSF001399, DHquinase_II, 1 hit |
SUPFAMi | SSF52304, SSF52304, 1 hit |
TIGRFAMsi | TIGR01088, aroQ, 1 hit |
PROSITEi | View protein in PROSITE PS01029, DEHYDROQUINASE_II, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AROQ_HELPY | |
Accessioni | Q48255Primary (citable) accession number: Q48255 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families