Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-ketoacyl-CoA thiolase

Gene

fadI

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei98Acyl-thioester intermediateUniRule annotation1
Active sitei391Proton acceptorUniRule annotation1
Active sitei421Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciCPSY167879:G1G4N-2885-MONOMER
UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
ACSsUniRule annotation
Acetyl-CoA acyltransferaseUniRule annotation
Acyl-CoA ligaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadIUniRule annotation
Ordered Locus Names:CPS_3157
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
Proteomesi
  • UP000000547 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002064351 – 4353-ketoacyl-CoA thiolaseAdd BLAST435

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).UniRule annotation

Protein-protein interaction databases

STRINGi167879.CPS_3157

Structurei

3D structure databases

ProteinModelPortaliQ47ZB6
SMRiQ47ZB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHU Bacteria
COG0183 LUCA
HOGENOMiHOG000012240
KOiK00632
OMAiMTAFPEP
OrthoDBiPOG091H065K

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 1 hit
HAMAPiMF_01618 FadI, 1 hit
InterProiView protein in InterPro
IPR012806 Ac-CoA_C-AcTrfase_FadI
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PANTHERiPTHR18919:SF113 PTHR18919:SF113, 1 hit
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 3 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
TIGR02446 FadI, 1 hit
PROSITEiView protein in PROSITE
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q47ZB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIKRLTTST GERIAIVAGL RTPFAKQATA FHGVPAVDLG KIVVNELLQK
60 70 80 90 100
HDVDPGIIDQ LVFGQVVQMP EAPNIAREIV LGTGMNTRTD AYSVSRACAT
110 120 130 140 150
SFQSTVNVAE SIMAGHVDVG IAGGADSSSV APIGVSKKLA RTLVDLTKAR
160 170 180 190 200
SLGQRLSLLS RLGLKDLLPV SPAVAEYSTG ISMGQTAEQM AKTYQISRQD
210 220 230 240 250
QDALAHRSHT LATKSWQEGK LAGEVMTVHA EPYKSFIDRD NCFRENSVLE
260 270 280 290 300
SYAKLKPVFD RKHGTVTAAT STPLTDGGAA ILLMREGRAK ELGYKPLGYI
310 320 330 340 350
RSFGFAAIDV WQDMLMGPSY ATPIALQRAG MNLADLDLIE MHEAFAAQAL
360 370 380 390 400
ANMKMFGSTK FAQEQLGRDK AIGDIDMDKF NVMGGSLAYG HPFAATGARL
410 420 430
ITQTLNELNR RGGGVGLTTA CAAGGLGAAM IVETD
Length:435
Mass (Da):46,348
Last modified:September 13, 2005 - v1
Checksum:i0901563D81209521
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA Translation: AAZ26685.1
RefSeqiWP_011043941.1, NC_003910.7

Genome annotation databases

EnsemblBacteriaiAAZ26685; AAZ26685; CPS_3157
KEGGicps:CPS_3157

Similar proteinsi

Entry informationi

Entry nameiFADI_COLP3
AccessioniPrimary (citable) accession number: Q47ZB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 13, 2005
Last modified: February 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health