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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Thermobifida fusca (strain YX)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei8Nucleophile; for GATase activityUniRule annotation1
Active sitei617For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:Tfu_2611Imported
OrganismiThermobifida fusca (strain YX)Imported
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesNocardiopsaceaeThermobifida
Proteomesi
  • UP000000434 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi269800.Tfu_2611

Structurei

3D structure databases

ProteinModelPortaliQ47LM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 227Glutamine amidotransferase type-2InterPro annotationAdd BLAST220
Domaini295 – 434SISInterPro annotationAdd BLAST140
Domaini467 – 612SISInterPro annotationAdd BLAST146

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q47LM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTLTLMCGI VGYVGPKPAL EVVVEGLARL EYRGYDSAGV AVLSDGKLQT
60 70 80 90 100
EKRAGKLANL RAALQANPRS ADGIGIGHTR WATHGAPTDG NAHPHVDEMN
110 120 130 140 150
RVAVVHNGII ENFAQLRMEL EERGCKFRSE TDTEVVAHML SEQLTEHNGD
160 170 180 190 200
LGAAMRSVCR RLEGAFTLVA ISEDDPGLVV AARRNSPLVV GRGNGENFLA
210 220 230 240 250
SDVAAFIAHT RDAIELGQDQ VVELRADSIT ITDYDGAPAQ VREYHVDWDA
260 270 280 290 300
SAAEKGGYDY FMLKEIAEQP RAIADTLLGR VAVDGTLTLD EMRLAPEELR
310 320 330 340 350
QISKIVIVAC GSSYHAGLIA KYAIEHWCRI PCEVEVASEF RYRDPILDPQ
360 370 380 390 400
TLVIAISQSG ESMDTLMAVR YAREQQSRVL AICNVNGSTI PRESDGVLYT
410 420 430 440 450
HAGPEVGVAA TKTFLTQLVA CYLVGLYLAQ VRGLKFGDEI NAIIGQLARM
460 470 480 490 500
PEQVEKVLNT VQPVRDLARS LAEAKTVLFL GRHVGYPVAM EGALKLKELA
510 520 530 540 550
YMHAEAFAAG ELKHGPIALI EDGLPVVVVV PSREGRSVLH DKIVSNIQEI
560 570 580 590 600
RARGARTIVI AEEGDESVRP YSDTLIEIPA VPTLLQPLVA TVPLQVFACE
610 620
LALAKGNDVD QPRNLAKSVT VE
Length:622
Mass (Da):67,422
Last modified:September 13, 2005 - v1
Checksum:iD07A8B1E92098B1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA Translation: AAZ56644.1

Genome annotation databases

EnsemblBacteriaiAAZ56644; AAZ56644; Tfu_2611
KEGGitfu:Tfu_2611

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA Translation: AAZ56644.1

3D structure databases

ProteinModelPortaliQ47LM8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269800.Tfu_2611

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ56644; AAZ56644; Tfu_2611
KEGGitfu:Tfu_2611

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ47LM8_THEFY
AccessioniPrimary (citable) accession number: Q47LM8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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