Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Francisella novicida
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi383 – 390ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Synonyms:valA
OrganismiFrancisella novicida
Taxonomic identifieri264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalUniRule annotationAdd BLAST21
Transmembranei67 – 87HelicalUniRule annotationAdd BLAST21
Transmembranei146 – 166HelicalUniRule annotationAdd BLAST21
Transmembranei169 – 189HelicalUniRule annotationAdd BLAST21
Transmembranei258 – 278HelicalUniRule annotationAdd BLAST21
Transmembranei284 – 304HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925811 – 593Lipid A export ATP-binding/permease protein MsbAAdd BLAST593

Proteomic databases

PRIDEiQ47908

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ47908
SMRiQ47908
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 319ABC transmembrane type-1UniRule annotationAdd BLAST295
Domaini351 – 585ABC transporterUniRule annotationAdd BLAST235

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1 Bacteria
COG1132 LUCA

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR011917 ABC_transpr_lipidA
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR02203 MsbA_lipidA, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51239 MSBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q47908-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNHQKVGTL YKRLLLQVKH LMAFSAFGCY RKYIFLSADA SMIYLINPIL
60 70 80 90 100
NYGFGPGGGI TKQSATILML MGVGMVGFIA LRSVGSFVSQ YFIGSLGQKV
110 120 130 140 150
VYKFRKDIYK RLMDLPASFF DKHSTGQIIS RLLYNVDQVT EATSTAIITV
160 170 180 190 200
VQDGTFVIGL IVVMFVSSWQ LSLFLIVVGP FLGLFISIIN KKFRNLSRNT
210 220 230 240 250
QSSMGNVTHT AEETIRNYKE IRIFGAQQKQ QNKFFKNLDY TYSQQIRTIA
260 270 280 290 300
LDALTSPVIQ IIASLVLAFS LFTIAIFGTN DGGGSSWLTA GSFASFFAAA
310 320 330 340 350
AAILKPIKNL TKVNVVIQKA VAATEDIFYI LDYPAEKETG SKELAKVDGN
360 370 380 390 400
VTIKDLSFAF GEHKVLSGVS VDIKAGQTVA FVGKSGSGKT TLTSIISRFY
410 420 430 440 450
TQHKGEILLD GVDTRELTLE NLRSHLSIVS QNVHLFDDTV YNNIAFGLSR
460 470 480 490 500
EVSEDEVIDA LKRANAYEFV QELSDGIHTN IGNNGSKLSG GQRQRISIAR
510 520 530 540 550
ALLKNAPVLI FDEATSALDN ESERVVQQAL ESLTESCTTI VIAHRLSTVE
560 570 580 590
NADKIVVMDG GKVVESGKHQ ELLEQGGLYT GSINRDFNST YAR
Length:593
Mass (Da):65,130
Last modified:April 13, 2004 - v2
Checksum:i004E90B90EC9D311
GO

Sequence cautioni

The sequence AAD15237 differs from that shown. Reason: Frameshift at position 21.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L17003 Genomic DNA Translation: AAD15237.1 Frameshift.

Similar proteinsi

Entry informationi

Entry nameiMSBA_FRANO
AccessioniPrimary (citable) accession number: Q47908
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: May 23, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health