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Protein

Membrane-associated protein UidC

Gene

uidC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the activity of the UidB (GusB) glucuronide transporter, on its own however it has no transport activity. Glucuronide transport does not occur in strain K12 due to a variant at position 100 of the UidB (GusB, AC P0CE44, AC P0CE45) protein.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPorin
Biological processIon transport, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G6866-MONOMER

Protein family/group databases

TCDBi1.B.25.1.5 the outer membrane porin (opr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated protein UidC
Gene namesi
Name:uidC
Synonyms:gusC
Ordered Locus Names:b1615, JW1607
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12668 uidC

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • pore complex Source: UniProtKB-KW

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000002262524 – 421Membrane-associated protein UidCAdd BLAST398

Proteomic databases

PaxDbiQ47706
PRIDEiQ47706

Expressioni

Inductioni

In the presence of glucuronides.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261073, 179 interactors
DIPiDIP-11088N
IntActiQ47706, 6 interactors
STRINGi316385.ECDH10B_1748

Structurei

3D structure databases

ProteinModelPortaliQ47706
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108QNI Bacteria
ENOG410XU8G LUCA
HOGENOMiHOG000120875
KOiK16140
OMAiGAMGQFA

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR005318 OM_porin_bac
IPR023614 Porin_dom_sf
PfamiView protein in Pfam
PF03573 OprD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q47706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKIVAMAVI CLTAASGLTS AYAAQLADDE AGLRIRLKNE LRRADKPSAG
60 70 80 90 100
AGRDIYAWVQ GGLLDFNSGY YSNIIGVEGG AYYVYKLGAR ADMSTRWYLD
110 120 130 140 150
GDKSFGFALG AVKIKPSENS LLKLGRFGTD YSYGSLPYRI PLMAGSSQRT
160 170 180 190 200
LPTVSEGALG YWALTPNIDL WGMWRSRVFL WTDSTTGIRD EGVYNSQTGK
210 220 230 240 250
YDKHRARSFL AASWHDDTSR YSLGASVQKD VSNQIQSILE KSIPLDPNYT
260 270 280 290 300
LKGELLGFYA QLEGLSRNTS QPNETALVSG QLTWNAPWGS VFGSGGYLRH
310 320 330 340 350
AMNGAVVDTD IGYPFSLSLD RNREGMQSWQ LGVNYRLTPQ FTLTFAPIVT
360 370 380 390 400
RGYESSKRDV RIEGTGILGG MNYRVSEGPL QGMNFFLAAD KGREKRDGST
410 420
LGDRLNYWDV KMSIQYDFML K
Length:421
Mass (Da):46,648
Last modified:June 27, 2006 - v3
Checksum:iE900FEBF9FE1C7EE
GO

Sequence cautioni

The sequence AAA68925 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106 – 109GFAL → ALP in AAA68925 (Ref. 1) Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14641 Genomic DNA Translation: AAA68925.1 Different initiation.
U00096 Genomic DNA Translation: AAC74687.2
AP009048 Genomic DNA Translation: BAE76482.1
PIRiA64918
RefSeqiNP_416132.2, NC_000913.3
WP_001227023.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74687; AAC74687; b1615
BAE76482; BAE76482; BAE76482
GeneIDi944820
KEGGiecj:JW1607
eco:b1615
PATRICifig|1411691.4.peg.646

Entry informationi

Entry nameiUIDC_ECOLI
AccessioniPrimary (citable) accession number: Q47706
Secondary accession number(s): P76178, Q2MB74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 27, 2006
Last modified: March 28, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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