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Protein

Microcin C7

Gene

mccA

Organism
Escherichia coli
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antibacterial peptide, active against enterobacteria including species of Klebsiella, Salmonella, Shigella, Yersinia and Proteus, and strains of E.coli. Inhibits protein translation by blocking aspartyl-tRNA synthetase function and inhibiting production of aminoacetylated tRNA-Asp.5 Publications

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Microcin C7
Short name:
MccC7
Alternative name(s):
Microcin C51
Short name:
McC
Short name:
MccC51
Short name:
Microcin C
Gene namesi
Name:mccAImported
Encoded oniPlasmid pMccC7Imported
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003415321 – 7Microcin C72 Publications7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-formylmethionine2 Publications1
Modified residuei7Aspartic acid 1-[(3-aminopropyl)(5'-adenosyl)phosphono]amide2 Publications1

Post-translational modificationi

The peptide moiety allows entry into the bacterial cell, where it undergoes proteolytic cleavage to release the aspartyl adenylate analog, which is responsible for aspartyl-tRNA synthetase inhibition. Can be processed by the non-specific oligopeptidases PepA, PepB and PepN.4 Publications

Keywords - PTMi

Formylation, Phosphoprotein

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
mccBQ475068EBI-7035319,EBI-7035293

Protein-protein interaction databases

IntActiQ47505, 1 interactor
MINTiQ47505

Structurei

Secondary structure

17
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ47505

Sequencei

Sequence statusi: Complete.

Length:7
Mass (Da):763
Last modified:November 1, 1996 - v1
Checksum:i644DD44861B406F0
GO

Mass spectrometryi

Molecular mass is 1177±1 Da from positions 1 - 7. Determined by ESI. 2 Publications
Molecular mass is 1177.5 Da from positions 1 - 7. Determined by PD. 2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57583 Genomic DNA Translation: CAA40808.1
PIRiS45311

Entry informationi

Entry nameiMCCC7_ECOLX
AccessioniPrimary (citable) accession number: Q47505
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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