UniProtKB - Q47142 (HCAT_ECOLI)
Protein
Probable 3-phenylpropionic acid transporter
Gene
hcaT
Organism
Escherichia coli (strain K12)
Status
Functioni
Probable permease involved in the uptake of 3-phenylpropionic acid.
GO - Molecular functioni
- lactose:proton symporter activity Source: GO_Central
- lactose binding Source: GO_Central
GO - Biological processi
- organic substance transport Source: GO_Central
Keywordsi
Biological process | Symport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:HCAT-MONOMER |
Protein family/group databases
TCDBi | 2.A.1.27.1, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Probable 3-phenylpropionic acid transporter |
Gene namesi | Name:hcaT Synonyms:yfhS Ordered Locus Names:b2536, JW2520 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 4 | CytoplasmicBy similarity | 4 | |
Transmembranei | 5 – 31 | Helical; Name=1By similarityAdd BLAST | 27 | |
Topological domaini | 32 – 37 | PeriplasmicBy similarity | 6 | |
Transmembranei | 38 – 66 | Helical; Name=2By similarityAdd BLAST | 29 | |
Topological domaini | 67 – 70 | CytoplasmicBy similarity | 4 | |
Transmembranei | 71 – 96 | Helical; Name=3By similarityAdd BLAST | 26 | |
Topological domaini | 97 – 100 | PeriplasmicBy similarity | 4 | |
Transmembranei | 101 – 118 | Helical; Name=4By similarityAdd BLAST | 18 | |
Topological domaini | 119 – 129 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 130 – 152 | Helical; Name=5By similarityAdd BLAST | 23 | |
Topological domaini | 153 – 155 | PeriplasmicBy similarity | 3 | |
Transmembranei | 156 – 175 | Helical; Name=6By similarityAdd BLAST | 20 | |
Topological domaini | 176 – 207 | CytoplasmicBy similarityAdd BLAST | 32 | |
Transmembranei | 208 – 227 | Helical; Name=7By similarityAdd BLAST | 20 | |
Topological domaini | 228 – 231 | PeriplasmicBy similarity | 4 | |
Transmembranei | 232 – 256 | Helical; Name=8By similarityAdd BLAST | 25 | |
Topological domaini | 257 – 266 | CytoplasmicBy similarity | 10 | |
Transmembranei | 267 – 286 | Helical; Name=9By similarityAdd BLAST | 20 | |
Topological domaini | 287 – 289 | PeriplasmicBy similarity | 3 | |
Transmembranei | 290 – 312 | Helical; Name=10By similarityAdd BLAST | 23 | |
Topological domaini | 313 – 323 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 324 – 351 | Helical; Name=11By similarityAdd BLAST | 28 | |
Topological domaini | 352 – 354 | PeriplasmicBy similarity | 3 | |
Transmembranei | 355 – 375 | Helical; Name=12By similarityAdd BLAST | 21 | |
Topological domaini | 376 – 379 | CytoplasmicBy similarity | 4 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000196189 | 1 – 379 | Probable 3-phenylpropionic acid transporterAdd BLAST | 379 |
Proteomic databases
PaxDbi | Q47142 |
PRIDEi | Q47142 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261387, 11 interactors |
STRINGi | 511145.b2536 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Phenyl propionate permease (PPP) (TC 2.A.1.27) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_013133_6_0_6 |
InParanoidi | Q47142 |
PhylomeDBi | Q47142 |
Family and domain databases
InterProi | View protein in InterPro IPR026032, HcaT IPR024989, MFS_assoc_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF12832, MFS_1_like, 1 hit |
PIRSFi | PIRSF004925, HcaT, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00902, 2A0127, 1 hit |
i Sequence
Sequence statusi: Complete.
Q47142-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVLQSTRWLA LGYFTYFFSY GIFLPFWSVW LKGIGLTPET IGLLLGAGLV
60 70 80 90 100
ARFLGSLLIA PRVSDPSRLI SALRVLALLT LLFAVAFWAG AHVAWLMLVM
110 120 130 140 150
IGFNLFFSPL VPLTDALANT WQKQFPLDYG KVRLWGSVAF VIGSALTGKL
160 170 180 190 200
VTMFDYRVIL ALLTLGVASM LLGFLIRPTI QPQGASRQQE STGWSAWLAL
210 220 230 240 250
VRQNWRFLAC VCLLQGAHAA YYGFSAIYWQ AAGYSASAVG YLWSLGVVAE
260 270 280 290 300
VIIFALSNKL FRRCSARDML LISAICGVVR WGIMGATTAL PWLIVVQILH
310 320 330 340 350
CGTFTVCHLA AMRYIAARQG SEVIRLQAVY SAVAMGGSIA IMTVFAGFLY
360 370
QYLGHGVFWV MALVALPAMF LRPKVVPSC
Sequence cautioni
The sequence CAA86021 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 191 | S → N in CAA71954 (PubMed:9603882).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z37966 Genomic DNA Translation: CAA86021.1 Frameshift. Y11071 Genomic DNA Translation: CAA71954.1 U00096 Genomic DNA Translation: AAC75589.1 AP009048 Genomic DNA Translation: BAA16431.1 |
PIRi | G65030 S49295 |
RefSeqi | NP_417031.1, NC_000913.3 WP_000244193.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75589; AAC75589; b2536 BAA16431; BAA16431; BAA16431 |
GeneIDi | 57732362 947007 |
KEGGi | ecj:JW2520 eco:b2536 |
PATRICi | fig|1411691.4.peg.4198 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z37966 Genomic DNA Translation: CAA86021.1 Frameshift. Y11071 Genomic DNA Translation: CAA71954.1 U00096 Genomic DNA Translation: AAC75589.1 AP009048 Genomic DNA Translation: BAA16431.1 |
PIRi | G65030 S49295 |
RefSeqi | NP_417031.1, NC_000913.3 WP_000244193.1, NZ_LN832404.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4261387, 11 interactors |
STRINGi | 511145.b2536 |
Protein family/group databases
TCDBi | 2.A.1.27.1, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | Q47142 |
PRIDEi | Q47142 |
Genome annotation databases
EnsemblBacteriai | AAC75589; AAC75589; b2536 BAA16431; BAA16431; BAA16431 |
GeneIDi | 57732362 947007 |
KEGGi | ecj:JW2520 eco:b2536 |
PATRICi | fig|1411691.4.peg.4198 |
Organism-specific databases
EchoBASEi | EB3227 |
Phylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_013133_6_0_6 |
InParanoidi | Q47142 |
PhylomeDBi | Q47142 |
Enzyme and pathway databases
BioCyci | EcoCyc:HCAT-MONOMER |
Miscellaneous databases
PROi | PR:Q47142 |
Family and domain databases
InterProi | View protein in InterPro IPR026032, HcaT IPR024989, MFS_assoc_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF12832, MFS_1_like, 1 hit |
PIRSFi | PIRSF004925, HcaT, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00902, 2A0127, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HCAT_ECOLI | |
Accessioni | Q47142Primary (citable) accession number: Q47142 Secondary accession number(s): O05660, P77638 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families