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Protein

HTH-type transcriptional regulator cbl

Gene

cbl

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be an accessory regulatory protein within the cys regulon.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi19 – 38H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • positive regulation of sulfur utilization Source: EcoliWiki
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7071-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator cbl
Gene namesi
Name:cbl
Ordered Locus Names:b1987, JW1966
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14264 cbl

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056021 – 316HTH-type transcriptional regulator cblAdd BLAST316

Proteomic databases

PaxDbiQ47083
PRIDEiQ47083

Interactioni

Protein-protein interaction databases

BioGridi4262113, 6 interactors
DIPiDIP-9248N
IntActiQ47083, 2 interactors
STRINGi316385.ECDH10B_2131

Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni88 – 90Combined sources3
Beta strandi93 – 99Combined sources7
Helixi101 – 106Combined sources6
Helixi108 – 118Combined sources11
Beta strandi122 – 128Combined sources7
Helixi131 – 139Combined sources9
Beta strandi144 – 152Combined sources9
Beta strandi158 – 166Combined sources9
Beta strandi168 – 173Combined sources6
Helixi177 – 179Combined sources3
Beta strandi181 – 183Combined sources3
Helixi186 – 189Combined sources4
Beta strandi194 – 197Combined sources4
Helixi204 – 213Combined sources10
Beta strandi220 – 226Combined sources7
Helixi227 – 236Combined sources10
Beta strandi240 – 244Combined sources5
Helixi245 – 248Combined sources4
Beta strandi256 – 259Combined sources4
Turni262 – 264Combined sources3
Beta strandi268 – 275Combined sources8
Helixi282 – 291Combined sources10
Beta strandi293 – 295Combined sources3
Helixi297 – 305Combined sources9

3D structure databases

ProteinModelPortaliQ47083
SMRiQ47083
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ47083

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 59HTH lysR-typePROSITE-ProRule annotationAdd BLAST59

Phylogenomic databases

eggNOGiENOG4107R11 Bacteria
ENOG410XP61 LUCA
HOGENOMiHOG000260068
InParanoidiQ47083
KOiK13635
OMAiYDNAFAG
PhylomeDBiQ47083

Family and domain databases

CDDicd08444 PBP2_Cbl, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037408 Cbl_PBP2
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

Q47083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFQQLKIIR EAARQDYNLT EVANMLFTSQ SGVSRHIREL EDELGIEIFV
60 70 80 90 100
RRGKRLLGMT EPGKALLVIA ERILNEASNV RRLADLFTND TSGVLTIATT
110 120 130 140 150
HTQARYSLPE VIKAFRELFP EVRLELIQGT PQEIATLLQN GEADIGIASE
160 170 180 190 200
RLSNDPQLVA FPWFRWHHSL LVPHDHPLTQ ISPLTLESIA KWPLITYRQG
210 220 230 240 250
ITGRSRIDDA FARKGLLADI VLSAQDSDVI KTYVALGLGI GLVAEQSSGE
260 270 280 290 300
QEEENLIRLD TRHLFDANTV WLGLKRGQLQ RNYVWRFLEL CNAGLSVEDI
310
KRQVMESSEE EIDYQI
Length:316
Mass (Da):35,856
Last modified:November 1, 1997 - v2
Checksum:i70CB59476501067C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143A → R in AAA99929 (PubMed:8529872).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31639 Genomic DNA Translation: AAA99929.1
U00096 Genomic DNA Translation: AAC75049.1
AP009048 Genomic DNA Translation: BAA15805.1
PIRiC64963
RefSeqiNP_416492.1, NC_000913.3
WP_001011008.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75049; AAC75049; b1987
BAA15805; BAA15805; BAA15805
GeneIDi946502
KEGGiecj:JW1966
eco:b1987
PATRICifig|1411691.4.peg.266

Similar proteinsi

Entry informationi

Entry nameiCBL_ECOLI
AccessioniPrimary (citable) accession number: Q47083
Secondary accession number(s): P76353
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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