UniProtKB - Q47005 (NAC_ECOLI)
Protein
Nitrogen assimilation regulatory protein nac
Gene
nac
Organism
Escherichia coli (strain K12)
Status
Functioni
Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 18 – 37 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: EcoCyc
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: EcoCyc
- nitrate assimilation Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: EcoCyc
- regulation of DNA-templated transcription, initiation Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Nitrate assimilation, Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:G7072-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Nitrogen assimilation regulatory protein nacAlternative name(s): Nitrogen assimilation control protein |
Gene namesi | Name:nac Ordered Locus Names:b1988, JW1967 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000105686 | 1 – 305 | Nitrogen assimilation regulatory protein nacAdd BLAST | 305 |
Proteomic databases
PaxDbi | Q47005 |
PRIDEi | Q47005 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260407, 8 interactors |
IntActi | Q47005, 1 interactor |
STRINGi | 511145.b1988 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 58 | HTH lysR-typePROSITE-ProRule annotationAdd BLAST | 58 |
Sequence similaritiesi
Belongs to the LysR transcriptional regulatory family.Curated
Phylogenomic databases
eggNOGi | COG0583, Bacteria |
HOGENOMi | CLU_039613_6_5_6 |
InParanoidi | Q47005 |
PhylomeDBi | Q47005 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005119, LysR_subst-bd IPR000847, Tscrpt_reg_HTH_LysR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00126, HTH_1, 1 hit PF03466, LysR_substrate, 1 hit |
PRINTSi | PR00039, HTHLYSR |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50931, HTH_LYSR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q47005-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNFRRLKYFV KIVDIGSLTQ AAEVLHIAQP ALSQQVATLE GELNQQLLIR
60 70 80 90 100
TKRGVTPTDA GKILYTHARA ILRQCEQAQL AVHNVGQALS GQVSIGFAPG
110 120 130 140 150
TAASSITMPL LQAVRAEFPE IVIYLHENSG AVLNEKLINH QLDMAVIYEH
160 170 180 190 200
SPVAGVSSQA LLKEDLFLVG TQDCPGQSVD VNAIAQMNLF LPSDYSAIRL
210 220 230 240 250
RVDEAFSLRR LTAKVIGEIE SIATLTAAIA SGMGVAVLPE SAARSLCGAV
260 270 280 290 300
NGWMSRITTP SMSLSLSLNL PARANLSPQA QAVKELLMSV ISSPVMEKRQ
WQLVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U56736 Genomic DNA Translation: AAD14869.1 U00096 Genomic DNA Translation: AAC75050.1 AP009048 Genomic DNA Translation: BAA15806.1 L31639 Genomic DNA Translation: AAA99928.1 |
PIRi | D64963 |
RefSeqi | NP_416493.1, NC_000913.3 WP_001011462.1, NZ_SSUV01000031.1 |
Genome annotation databases
EnsemblBacteriai | AAC75050; AAC75050; b1988 BAA15806; BAA15806; BAA15806 |
GeneIDi | 946501 |
KEGGi | ecj:JW1967 eco:b1988 |
PATRICi | fig|1411691.4.peg.265 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U56736 Genomic DNA Translation: AAD14869.1 U00096 Genomic DNA Translation: AAC75050.1 AP009048 Genomic DNA Translation: BAA15806.1 L31639 Genomic DNA Translation: AAA99928.1 |
PIRi | D64963 |
RefSeqi | NP_416493.1, NC_000913.3 WP_001011462.1, NZ_SSUV01000031.1 |
3D structure databases
SMRi | Q47005 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260407, 8 interactors |
IntActi | Q47005, 1 interactor |
STRINGi | 511145.b1988 |
Proteomic databases
PaxDbi | Q47005 |
PRIDEi | Q47005 |
Protocols and materials databases
DNASUi | 946501 |
Genome annotation databases
EnsemblBacteriai | AAC75050; AAC75050; b1988 BAA15806; BAA15806; BAA15806 |
GeneIDi | 946501 |
KEGGi | ecj:JW1967 eco:b1988 |
PATRICi | fig|1411691.4.peg.265 |
Organism-specific databases
EchoBASEi | EB4013 |
Phylogenomic databases
eggNOGi | COG0583, Bacteria |
HOGENOMi | CLU_039613_6_5_6 |
InParanoidi | Q47005 |
PhylomeDBi | Q47005 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7072-MONOMER |
Miscellaneous databases
PROi | PR:Q47005 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005119, LysR_subst-bd IPR000847, Tscrpt_reg_HTH_LysR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00126, HTH_1, 1 hit PF03466, LysR_substrate, 1 hit |
PRINTSi | PR00039, HTHLYSR |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50931, HTH_LYSR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NAC_ECOLI | |
Accessioni | Q47005Primary (citable) accession number: Q47005 Secondary accession number(s): Q47082 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families