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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei629For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

BioCyciPMAR59920:G1G4T-1857-MONOMER

Protein family/group databases

MEROPSiC44.A08

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:PMN2A_1183Imported
OrganismiProchlorococcus marinus (strain NATL2A)Imported
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002535 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ46IK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 234Glutamine amidotransferase type-2InterPro annotationAdd BLAST233
Domaini302 – 451SISInterPro annotationAdd BLAST150
Domaini485 – 624SISInterPro annotationAdd BLAST140

Phylogenomic databases

HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061
PhylomeDBiQ46IK5

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q46IK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIFAVIGS REVSSLLIDG LRKLEYRGYD SAGIATIDNL NNDQIGQLNV
60 70 80 90 100
TKAKGKLINL SNLIKKKPPK GHVGIAHTRW ATHGKPNERN AHPHLDFSGQ
110 120 130 140 150
IAVVQNGIIE NYRDLSNSLK LKGIKLTSET DTEIIPHLIG LEIEHYLANG
160 170 180 190 200
LSPNEQTLLI AVQKVLTLLE GTYSIAVIWS KAPNALVVAR GQAPLVLGFG
210 220 230 240 250
EGEFFCASDT PALTGFTRTF LPLRDHESAL LTPLGIELYD DDGKRQHRAP
260 270 280 290 300
SIIEGAEFFA DKRNFRHFML KEIYEQPETA QQWIDRFLPM DLPSENPIAM
310 320 330 340 350
PVSKSILENI EQIQILACGT SRHAGMVGAY LLEQFAGVPT KVYFASEFRY
360 370 380 390 400
APPPLSPHTL TIGVSQSGET ADTLAALRME KERRDSTQDP NFSFHQLGIT
410 420 430 440 450
NRVDSSFGRE LENVIDIGSG IEIGVAATKT FLGQMLSFYG LTILFASHRQ
460 470 480 490 500
KRKSQEILDL SNDLRLIPKQ LTNLIKKHDS LSKEIAHLFV ETKDVIFLGR
510 520 530 540 550
GINYPIALEG ALKLKEISYI HAQGYPAGEL KHGPIALLDQ HVPVVSIAVP
560 570 580 590 600
GVVYEKVLSN SQEAKARDAR LIGVSTHRSE SEMFDELFTI PKVSEWVSPL
610 620 630
LTVVPLQLFS YHIAAHKGLD VDQPRNLAKS VTVE
Length:634
Mass (Da):70,102
Last modified:September 13, 2005 - v1
Checksum:i0E12BF248E7F39FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA Translation: AAZ58673.1
RefSeqiWP_011295527.1, NC_007335.2

Genome annotation databases

EnsemblBacteriaiAAZ58673; AAZ58673; PMN2A_1183
KEGGipmn:PMN2A_1183

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA Translation: AAZ58673.1
RefSeqiWP_011295527.1, NC_007335.2

3D structure databases

ProteinModelPortaliQ46IK5
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC44.A08

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ58673; AAZ58673; PMN2A_1183
KEGGipmn:PMN2A_1183

Phylogenomic databases

HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061
PhylomeDBiQ46IK5

Enzyme and pathway databases

BioCyciPMAR59920:G1G4T-1857-MONOMER

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ46IK5_PROMT
AccessioniPrimary (citable) accession number: Q46IK5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: February 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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