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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciPMAR59920:G1G4T-240-MONOMER
UniPathwayi
UPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:PMN2A_1564
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002535 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002250781 – 352UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseAdd BLAST352

Proteomic databases

PRIDEiQ46HH6

Structurei

3D structure databases

ProteinModelPortaliQ46HH6
SMRiQ46HH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218321
KOiK02563
OMAiHQTKNAM
OrthoDBiPOG091H02FX
PhylomeDBiQ46HH6

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit

Sequencei

Sequence statusi: Complete.

Q46HH6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRLLIAASG TGGHIYPALS FADSLSNSWE IVWLGVPHRL EVELVPEKYN
60 70 80 90 100
LIKLKVGGLQ GNSFRKLFNL CKLLFASVQV SVLLRQKKIN VIFTTGGYIS
110 120 130 140 150
APSILGAKMA GIPVLLHESN AIPGKVTRLL GRFCDHVALG IPSASEYLQR
160 170 180 190 200
CRTSFTGTPV RTEFLLEKSL PSWVPLGEGV LIVVMGGSQG AIKMNEMVRK
210 220 230 240 250
ILPCLIEKGC RVVHLTGKND CFYRNRDQEK NHPNLVVRDF SDEIPALLRN
260 270 280 290 300
ADLAISRSGA GAICELMVTK TPSILIPFPS STDQHQELNA AYMARFGGAI
310 320 330 340 350
IVNQHDPEKN ILKNIVSNLL DSNSLREMKL NMNNHDYSYP EKKIFEIIHS

IS
Length:352
Mass (Da):38,913
Last modified:September 13, 2005 - v1
Checksum:i3CF51DA49A0FEE38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA Translation: AAZ59052.1
RefSeqiWP_011294197.1, NC_007335.2

Genome annotation databases

EnsemblBacteriaiAAZ59052; AAZ59052; PMN2A_1564
KEGGipmn:PMN2A_1564

Similar proteinsi

Entry informationi

Entry nameiMURG_PROMT
AccessioniPrimary (citable) accession number: Q46HH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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