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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

apgM

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 1 (gap1), Glyceraldehyde-3-phosphate dehydrogenase 2 (gap2)
  2. Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (gpmI1), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (gpmI2), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. Pyruvate kinase (Mbar_A0175)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGlycolysis

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
aPGAMUniRule annotation
Gene namesi
Name:apgMUniRule annotation
Ordered Locus Names:Mbar_A0860
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000008156 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000683801 – 3982,3-bisphosphoglycerate-independent phosphoglycerate mutaseAdd BLAST398

Proteomic databases

PRIDEiQ46E58

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A0860

Structurei

3D structure databases

ProteinModelPortaliQ46E58
SMRiQ46E58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01696 Archaea
COG3635 LUCA
HOGENOMiHOG000004785
KOiK15635
OMAiFRCNLIT
OrthoDBiPOG093Z02JY

Family and domain databases

CDDicd16011 iPGM_like, 1 hit
Gene3Di3.40.720.10, 2 hits
HAMAPiMF_01402_A ApgM_A, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR023665 ApgAM_prokaryotes
IPR006124 Metalloenzyme
IPR004456 Pglycerate_mutase_ApgM
PANTHERiPTHR31209 PTHR31209, 1 hit
PfamiView protein in Pfam
PF01676 Metalloenzyme, 1 hit
PF10143 PhosphMutase, 1 hit
PIRSFiPIRSF006392 IPGAM_arch, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits
TIGRFAMsiTIGR00306 apgM, 1 hit
TIGR02535 hyp_Hser_kinase, 1 hit

Sequencei

Sequence statusi: Complete.

Q46E58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKYAVLIGDG MADYPIDKLG GKTILQAAQT PAMDYIAAHG KIGLAKTIPD
60 70 80 90 100
GLPAGSDVAN MSILGYDPAV YYSGRAPLEA ASMGVALASD DVAFRCNLVT
110 120 130 140 150
IEHGRIKDYS AGHISSEEAR ILIETLDAEL GNEELSFYPG ISYRHLLIAK
160 170 180 190 200
DNLGAETECT PPHDITGKKI EEYLPGGKEG DFFSDLIKKS MIVLELHPVN
210 220 230 240 250
LRRIEEGKNP ANSIWVWGQG SAPKFTPFRE LYEKTGAVIS AVDLLKGIGV
260 270 280 290 300
YAGMDVIEVQ GATGYLDTNY EGKASAAIEV LKTRDLVFVH VEAPDEAGHE
310 320 330 340 350
GSIDKKLKAV EDFDSRIVAP ILKHAKTSDE PFTILVLPDH PTPISIKTHA
360 370 380 390
RDPVPFAVYR TDKTDSDSAE AFDEESAKKG SLGLVKASDL IGILVKAK
Length:398
Mass (Da):42,895
Last modified:September 13, 2005 - v1
Checksum:i11A2604B38A2AF2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA Translation: AAZ69834.1
RefSeqiWP_011305883.1, NC_007355.1

Genome annotation databases

EnsemblBacteriaiAAZ69834; AAZ69834; Mbar_A0860
GeneIDi3627272
KEGGimba:Mbar_A0860

Similar proteinsi

Entry informationi

Entry nameiAPGM_METBF
AccessioniPrimary (citable) accession number: Q46E58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 13, 2005
Last modified: September 12, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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