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Protein

60 kDa chaperonin

Gene

groL

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation
Ordered Locus Names:Mbar_A1543
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000008156 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002570241 – 53660 kDa chaperoninAdd BLAST536

Proteomic databases

PRIDEiQ46CA1

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi269797.Mbar_A1543

Structurei

3D structure databases

ProteinModelPortaliQ46CA1
SMRiQ46CA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG05154 Archaea
COG0459 LUCA
HOGENOMiHOG000076290
KOiK04077
OMAiTDTDKME
OrthoDBiPOG093Z01WV

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Q46CA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKQIMFDE NARKALLNGV DKVANTVKIT LGPKGRYVVL DKSTKPVVTN
60 70 80 90 100
DGVTIAKEIE LHDKFENMGA KLVKEVASKT QDNTGDGTTT ATLLAQSMIR
110 120 130 140 150
EGLKNISAGA NPIDVKKGIE MATENVVGYL KSKSSEVKGK EKIVQVATVS
160 170 180 190 200
ANNDEEIGNL IADAMERVGY NGVITVEDSK TMETNLDVVE GMQFDRGFVS
210 220 230 240 250
PYMATDSEKM VCEFEDPYIL ITDKKINSMK QIVPVLEKVA SEGRSLLIIA
260 270 280 290 300
EDVDGDAQAA LILNIIRGAL RVCAVKAPGF GNERKEMLED IAVLTGGQVI
310 320 330 340 350
SEDKGMKLEE FDDYMLGSAR KVTIDNNKTI IVEGKGDKAK IKERVSLIEA
360 370 380 390 400
QINIADVEYK KTELKKRQAK LGGGVAVIKV GAATETELKE KKMRIDDALN
410 420 430 440 450
ATKAAVEEGV VIGGGISLFR AAAILDSLKL EGDREIGVKI VQRAIEEPVR
460 470 480 490 500
QIAENAGKEG AEVVATIRAE PRELFGYNAK KDVFEDLFEA GVIDPTKVVR
510 520 530
SGLQNAASIA GMVLTTEALV TDFNDEKDEK AATIII
Length:536
Mass (Da):57,927
Last modified:September 13, 2005 - v1
Checksum:i51F15D2F5EDC7A64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA Translation: AAZ70491.1
RefSeqiWP_011306537.1, NC_007355.1

Genome annotation databases

EnsemblBacteriaiAAZ70491; AAZ70491; Mbar_A1543
GeneIDi3625257
KEGGimba:Mbar_A1543

Similar proteinsi

Entry informationi

Entry nameiCH60_METBF
AccessioniPrimary (citable) accession number: Q46CA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2005
Last modified: July 18, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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