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Entry version 130 (02 Dec 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Inner membrane permease YgbN

Gene

ygbN

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:B2740-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.8.1.7, the gluconate:h(+) symporter (gntp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inner membrane permease YgbN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ygbN
Ordered Locus Names:b2740, JW2710
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1PeriplasmicSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 27CytoplasmicSequence analysis5
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Topological domaini49 – 52PeriplasmicSequence analysis4
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 108CytoplasmicSequence analysisAdd BLAST35
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 137PeriplasmicSequence analysis8
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 174CytoplasmicSequence analysisAdd BLAST16
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 235PeriplasmicSequence analysisAdd BLAST40
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 273CytoplasmicSequence analysisAdd BLAST17
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 305PeriplasmicSequence analysisAdd BLAST11
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 341CytoplasmicSequence analysisAdd BLAST15
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 383PeriplasmicSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 433CytoplasmicSequence analysisAdd BLAST29
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000619431 – 454Inner membrane permease YgbNAdd BLAST454

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q46892

PRoteomics IDEntifications database

More...
PRIDEi
Q46892

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4260990, 160 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2740

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GntP permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
COG2610, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027949_0_2_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q46892

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q46892

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003474, Glcn_transporter

The PANTHER Classification System

More...
PANTHERi
PTHR30354, PTHR30354, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02447, GntP_permease, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002746, Gluconate_transporter, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00791, gntP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q46892-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTITLLCIA LAGVIMLLLL VIKAKVQPFV ALLLVSLLVA LAAGIPAGEV
60 70 80 90 100
GKVMIAGMGG VLGSVTIIIG LGAMLGRMIE HSGGAESLAN YFSRKLGDKR
110 120 130 140 150
TIAALTLAAF FLGIPVFFDV GFIILAPIIY GFAKVAKISP LKFGLPVAGI
160 170 180 190 200
MLTVHVAVPP HPGPVAAAGL LHADIGWLTI IGIAISIPVG VVGYFAAKII
210 220 230 240 250
NKRQYAMSVE VLEQMQLAPA SEEGATKLSD KINPPGVALV TSLIVIPIAI
260 270 280 290 300
IMAGTVSATL MPPSHPLLGT LQLIGSPMVA LMIALVLAFW LLALRRGWSL
310 320 330 340 350
QHTSDIMGSA LPTAAVVILV TGAGGVFGKV LVESGVGKAL ANMLQMIDLP
360 370 380 390 400
LLPAAFIISL ALRASQGSAT VAILTTGGLL SEAVMGLNPI QCVLVTLAAC
410 420 430 440 450
FGGLGASHIN DSGFWIVTKY LGLSVADGLK TWTVLTTILG FTGFLITWCV

WAVI
Length:454
Mass (Da):46,770
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i567B17E06586C2B9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U29579 Genomic DNA Translation: AAA69250.1
U00096 Genomic DNA Translation: AAC75782.1
AP009048 Genomic DNA Translation: BAE76817.1

Protein sequence database of the Protein Information Resource

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PIRi
H65054

NCBI Reference Sequences

More...
RefSeqi
NP_417220.1, NC_000913.3
WP_000104441.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75782; AAC75782; b2740
BAE76817; BAE76817; BAE76817

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947208

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2710
eco:b2740

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.4000

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29579 Genomic DNA Translation: AAA69250.1
U00096 Genomic DNA Translation: AAC75782.1
AP009048 Genomic DNA Translation: BAE76817.1
PIRiH65054
RefSeqiNP_417220.1, NC_000913.3
WP_000104441.1, NZ_LN832404.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4260990, 160 interactors
STRINGi511145.b2740

Protein family/group databases

TCDBi2.A.8.1.7, the gluconate:h(+) symporter (gntp) family

Proteomic databases

PaxDbiQ46892
PRIDEiQ46892

Genome annotation databases

EnsemblBacteriaiAAC75782; AAC75782; b2740
BAE76817; BAE76817; BAE76817
GeneIDi947208
KEGGiecj:JW2710
eco:b2740
PATRICifig|1411691.4.peg.4000

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2911

Phylogenomic databases

eggNOGiCOG2610, Bacteria
HOGENOMiCLU_027949_0_2_6
InParanoidiQ46892
PhylomeDBiQ46892

Enzyme and pathway databases

BioCyciEcoCyc:B2740-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q46892

Family and domain databases

InterProiView protein in InterPro
IPR003474, Glcn_transporter
PANTHERiPTHR30354, PTHR30354, 1 hit
PfamiView protein in Pfam
PF02447, GntP_permease, 1 hit
PIRSFiPIRSF002746, Gluconate_transporter, 1 hit
TIGRFAMsiTIGR00791, gntP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYGBN_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q46892
Secondary accession number(s): Q2MA89
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: December 2, 2020
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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