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UniProtKB - Q46891 (OTNI_ECOLI)
Protein
2-oxo-tetronate isomerase
Gene
otnI
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the isomerization of 2-oxo-tetronate to 3-oxo-tetronate.
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 143 | Proton donor/acceptorBy similarity | 1 | |
Metal bindingi | 143 | MagnesiumCombined sources1 Publication | 1 | |
Metal bindingi | 178 | MagnesiumCombined sources1 Publication | 1 | |
Metal bindingi | 204 | MagnesiumCombined sources1 Publication | 1 | |
Active sitei | 240 | Proton donor/acceptorBy similarity | 1 | |
Metal bindingi | 240 | MagnesiumCombined sources1 Publication | 1 |
GO - Molecular functioni
- hydroxypyruvate isomerase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- carbohydrate metabolic process Source: UniProtKB-KW
- glyoxylate metabolic process Source: GO_Central
Keywordsi
Molecular function | Isomerase |
Biological process | Carbohydrate metabolism |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G7420-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: 2-oxo-tetronate isomeraseBy similarity (EC:5.3.1.35By similarity)Alternative name(s): 2-dehydrotetronate isomeraseCurated Glyoxylate-induced protein YgbM |
Gene namesi | Name:otnIBy similarity Synonyms:ygbM Ordered Locus Names:b2739, JW2709 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209109 | 1 – 258 | 2-oxo-tetronate isomeraseAdd BLAST | 258 |
Proteomic databases
jPOSTi | Q46891 |
PaxDbi | Q46891 |
PRIDEi | Q46891 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261446, 5 interactors |
IntActi | Q46891, 1 interactor |
STRINGi | 511145.b2739 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q46891 |
SMRi | Q46891 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q46891 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG3622, Bacteria |
HOGENOMi | CLU_050006_1_2_6 |
InParanoidi | Q46891 |
OMAi | CEYRPRA |
PhylomeDBi | Q46891 |
Family and domain databases
InterProi | View protein in InterPro IPR026040, HyI-like IPR036237, Xyl_isomerase-like_sf IPR013022, Xyl_isomerase-like_TIM-brl |
Pfami | View protein in Pfam PF01261, AP_endonuc_2, 1 hit |
PIRSFi | PIRSF006241, HyI, 1 hit |
SUPFAMi | SSF51658, SSF51658, 1 hit |
i Sequence
Sequence statusi: Complete.
Q46891-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRFAANLSM MFTEVPFIER FAAARKAGFD AVEFLFPYNY STLQIQKQLE
60 70 80 90 100
QNHLTLALFN TAPGDINAGE WGLSALPGRE HEAHADIDLA LEYALALNCE
110 120 130 140 150
QVHVMAGVVP AGEDAERYRA VFIDNIRYAA DRFAPHGKRI LVEALSPGVK
160 170 180 190 200
PHYLFSSQYQ ALAIVEEVAR DNVFIQLDTF HAQKVDGNLT HLIRDYAGKY
210 220 230 240 250
AHVQIAGLPD RHEPDDGEIN YPWLFRLFDE VGYQGWIGCE YKPRGLTEEG
LGWFDAWR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29579 Genomic DNA Translation: AAA69249.1 U00096 Genomic DNA Translation: AAC75781.1 AP009048 Genomic DNA Translation: BAE76816.1 |
PIRi | G65054 |
RefSeqi | NP_417219.1, NC_000913.3 WP_001136934.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75781; AAC75781; b2739 BAE76816; BAE76816; BAE76816 |
GeneIDi | 947207 |
KEGGi | ecj:JW2709 eco:b2739 |
PATRICi | fig|511145.12.peg.2833 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29579 Genomic DNA Translation: AAA69249.1 U00096 Genomic DNA Translation: AAC75781.1 AP009048 Genomic DNA Translation: BAE76816.1 |
PIRi | G65054 |
RefSeqi | NP_417219.1, NC_000913.3 WP_001136934.1, NZ_LN832404.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1K77 | X-ray | 1.63 | A | 1-258 | [»] | |
AlphaFoldDBi | Q46891 | |||||
SMRi | Q46891 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261446, 5 interactors |
IntActi | Q46891, 1 interactor |
STRINGi | 511145.b2739 |
Chemistry databases
DrugBanki | DB01942, Formic acid |
Proteomic databases
jPOSTi | Q46891 |
PaxDbi | Q46891 |
PRIDEi | Q46891 |
Genome annotation databases
EnsemblBacteriai | AAC75781; AAC75781; b2739 BAE76816; BAE76816; BAE76816 |
GeneIDi | 947207 |
KEGGi | ecj:JW2709 eco:b2739 |
PATRICi | fig|511145.12.peg.2833 |
Organism-specific databases
EchoBASEi | EB2910 |
Phylogenomic databases
eggNOGi | COG3622, Bacteria |
HOGENOMi | CLU_050006_1_2_6 |
InParanoidi | Q46891 |
OMAi | CEYRPRA |
PhylomeDBi | Q46891 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7420-MONOMER |
Miscellaneous databases
EvolutionaryTracei | Q46891 |
PROi | PR:Q46891 |
Family and domain databases
InterProi | View protein in InterPro IPR026040, HyI-like IPR036237, Xyl_isomerase-like_sf IPR013022, Xyl_isomerase-like_TIM-brl |
Pfami | View protein in Pfam PF01261, AP_endonuc_2, 1 hit |
PIRSFi | PIRSF006241, HyI, 1 hit |
SUPFAMi | SSF51658, SSF51658, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OTNI_ECOLI | |
Accessioni | Q46891Primary (citable) accession number: Q46891 Secondary accession number(s): Q2MA90 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families