UniProtKB - Q46890 (OTNC_ECOLI)
Protein
3-oxo-tetronate 4-phosphate decarboxylase
Gene
otnC
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the decarboxylation of 3-oxo-tetronate 4-phosphate to dihydroxyacetone phosphate (DHAP) and CO2.By similarity
Catalytic activityi
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 79 | Proton acceptorBy similarity | 1 | |
Metal bindingi | 79 | ZincBy similarity | 1 | |
Metal bindingi | 98 | ZincBy similarity | 1 | |
Metal bindingi | 100 | ZincBy similarity | 1 | |
Active sitei | 125 | Proton donorBy similarity | 1 | |
Metal bindingi | 165 | ZincBy similarity | 1 |
GO - Molecular functioni
- aldehyde-lyase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- pentose catabolic process Source: GO_Central
Keywordsi
Molecular function | Lyase |
Biological process | Carbohydrate metabolism |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | EcoCyc:G7419-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:otnCBy similarity Synonyms:ygbL Ordered Locus Names:b2738, JW2708 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000162930 | 1 – 212 | 3-oxo-tetronate 4-phosphate decarboxylaseAdd BLAST | 212 |
Proteomic databases
PaxDbi | Q46890 |
PRIDEi | Q46890 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261445, 11 interactors |
DIPi | DIP-12113N |
IntActi | Q46890, 2 interactors |
STRINGi | 511145.b2738 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q46890 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0235, Bacteria |
HOGENOMi | CLU_006033_3_2_6 |
InParanoidi | Q46890 |
PhylomeDBi | Q46890 |
Family and domain databases
Gene3Di | 3.40.225.10, 1 hit |
InterProi | View protein in InterPro IPR001303, Aldolase_II/adducin_N IPR036409, Aldolase_II/adducin_N_sf |
Pfami | View protein in Pfam PF00596, Aldolase_II, 1 hit |
SMARTi | View protein in SMART SM01007, Aldolase_II, 1 hit |
SUPFAMi | SSF53639, SSF53639, 1 hit |
i Sequence
Sequence statusi: Complete.
Q46890-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDFAKVEQS LREEMTRIAS SFFQRGYATG SAGNLSLLLP DGNLLATPTG
60 70 80 90 100
SCLGNLDPQR LSKVAADGEW LSGDKPSKEV LFHLALYRNN PRCKAVVHLH
110 120 130 140 150
STWSTALSCL QGLDSSNVIR PFTPYVVMRM GNVPLVPYYR PGDKRIAQDL
160 170 180 190 200
AELAADNQAF LLANHGPVVC GESLQEAANN MEELEETAKL IFILGDRPIR
210
YLTAGEIAEL RS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF242208 Genomic DNA Translation: AAG14969.1 AF242210 Genomic DNA Translation: AAG14982.1 U29579 Genomic DNA Translation: AAA69248.1 U00096 Genomic DNA Translation: AAC75780.1 AP009048 Genomic DNA Translation: BAE76815.1 |
PIRi | F65054 |
RefSeqi | NP_417218.1, NC_000913.3 WP_001278994.1, NZ_STEB01000027.1 |
Genome annotation databases
EnsemblBacteriai | AAC75780; AAC75780; b2738 BAE76815; BAE76815; BAE76815 |
GeneIDi | 57728604 947197 |
KEGGi | ecj:JW2708 eco:b2738 |
PATRICi | fig|1411691.4.peg.4002 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF242208 Genomic DNA Translation: AAG14969.1 AF242210 Genomic DNA Translation: AAG14982.1 U29579 Genomic DNA Translation: AAA69248.1 U00096 Genomic DNA Translation: AAC75780.1 AP009048 Genomic DNA Translation: BAE76815.1 |
PIRi | F65054 |
RefSeqi | NP_417218.1, NC_000913.3 WP_001278994.1, NZ_STEB01000027.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6VOP | X-ray | 2.65 | A | 1-212 | [»] | |
SMRi | Q46890 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261445, 11 interactors |
DIPi | DIP-12113N |
IntActi | Q46890, 2 interactors |
STRINGi | 511145.b2738 |
Proteomic databases
PaxDbi | Q46890 |
PRIDEi | Q46890 |
Genome annotation databases
EnsemblBacteriai | AAC75780; AAC75780; b2738 BAE76815; BAE76815; BAE76815 |
GeneIDi | 57728604 947197 |
KEGGi | ecj:JW2708 eco:b2738 |
PATRICi | fig|1411691.4.peg.4002 |
Organism-specific databases
EchoBASEi | EB2909 |
Phylogenomic databases
eggNOGi | COG0235, Bacteria |
HOGENOMi | CLU_006033_3_2_6 |
InParanoidi | Q46890 |
PhylomeDBi | Q46890 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7419-MONOMER |
Miscellaneous databases
PROi | PR:Q46890 |
Family and domain databases
Gene3Di | 3.40.225.10, 1 hit |
InterProi | View protein in InterPro IPR001303, Aldolase_II/adducin_N IPR036409, Aldolase_II/adducin_N_sf |
Pfami | View protein in Pfam PF00596, Aldolase_II, 1 hit |
SMARTi | View protein in SMART SM01007, Aldolase_II, 1 hit |
SUPFAMi | SSF53639, SSF53639, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OTNC_ECOLI | |
Accessioni | Q46890Primary (citable) accession number: Q46890 Secondary accession number(s): Q2MA91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families