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Entry version 140 (26 Feb 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Glycolate permease GlcA

Gene

glcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by carbonyl cyanide m-chlorophenylhydrazone (CCCP).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:B2975-MONOMER
ECOL316407:JW2942-MONOMER
MetaCyc:B2975-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.14.1.2 the lactate permease (lctp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycolate permease GlcA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:glcA
Synonyms:yghK
Ordered Locus Names:b2975, JW2942
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 41PeriplasmicSequence analysis7
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 69CytoplasmicSequence analysis7
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 130PeriplasmicSequence analysisAdd BLAST40
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 158CytoplasmicSequence analysis7
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 199PeriplasmicSequence analysisAdd BLAST20
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 225CytoplasmicSequence analysis5
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 248PeriplasmicSequence analysis2
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 313CytoplasmicSequence analysisAdd BLAST44
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 378PeriplasmicSequence analysisAdd BLAST44
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 409CytoplasmicSequence analysis10
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Topological domaini431 – 439PeriplasmicSequence analysis9
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 537CytoplasmicSequence analysisAdd BLAST77
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Topological domaini559 – 560PeriplasmicSequence analysis2

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002103801 – 560Glycolate permease GlcAAdd BLAST560

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q46839

PRoteomics IDEntifications database

More...
PRIDEi
Q46839

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By glycolate.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
851589, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-12206N

Protein interaction database and analysis system

More...
IntActi
Q46839, 2 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2975

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lactate permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DAA Bacteria
COG1620 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021628_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q46839

KEGG Orthology (KO)

More...
KOi
K02550

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q46839

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003804 Lactate_perm

The PANTHER Classification System

More...
PANTHERi
PTHR30003 PTHR30003, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02652 Lactate_perm, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00795 lctP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q46839-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTWTQMYMP MGGLGLSALV ALIPIIFFFV ALAVLRLKGH VAGAITLILS
60 70 80 90 100
ILIAIFAFKM PIDMAFAAAG YGFIYGLWPI AWIIVAAVFL YKLTVASGQF
110 120 130 140 150
DIIRSSVISI TDDQRLQVLL IGFSFGALLE GAAGFGAPVA ITGALLVGLG
160 170 180 190 200
FKPLYAAGLC LIANTAPVAF GALGVPILVA GQVTGIDPFH IGAMAGRQLP
210 220 230 240 250
FLSVLVPFWL VAMMDGWKGV KETWPAALVA GGSFAVTQFF TSNYIGPELP
260 270 280 290 300
DITSALVSIV SLALFLKVWR PKNTETAISM GQSAGAMVVN KPSSGGPVPS
310 320 330 340 350
EYSLGQIIRA WSPFLILTVL VTIWTMKPFK ALFAPGGAFY SLVINFQIPH
360 370 380 390 400
LHQQVLKAAP IVAQPTPMDA VFKFDPLSAG GTAIFIAAII SIFILGVGIK
410 420 430 440 450
KGIGVFAETL ISLKWPILSI GMVLAFAFVT NYSGMSTTLA LVLAGTGVMF
460 470 480 490 500
PFFSPFLGWL GVFLTGSDTS SNALFGSLQS TTAQQINVSD TLLVAANTSG
510 520 530 540 550
GVTGKMISPQ SIAVACAATG MVGRESELFR YTVKHSLIFA SVIGIITLLQ
560
AYVFTGMLVS
Length:560
Mass (Da):58,920
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8ECB9F9626FFC40A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69142.1
U00096 Genomic DNA Translation: AAC76011.1
AP009048 Genomic DNA Translation: BAE77035.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E65083

NCBI Reference Sequences

More...
RefSeqi
NP_417449.1, NC_000913.3
WP_000259302.1, NZ_SSUV01000003.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76011; AAC76011; b2975
BAE77035; BAE77035; BAE77035

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947259

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2942
eco:b2975

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3756

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69142.1
U00096 Genomic DNA Translation: AAC76011.1
AP009048 Genomic DNA Translation: BAE77035.1
PIRiE65083
RefSeqiNP_417449.1, NC_000913.3
WP_000259302.1, NZ_SSUV01000003.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi851589, 1 interactor
DIPiDIP-12206N
IntActiQ46839, 2 interactors
STRINGi511145.b2975

Protein family/group databases

TCDBi2.A.14.1.2 the lactate permease (lctp) family

Proteomic databases

PaxDbiQ46839
PRIDEiQ46839

Genome annotation databases

EnsemblBacteriaiAAC76011; AAC76011; b2975
BAE77035; BAE77035; BAE77035
GeneIDi947259
KEGGiecj:JW2942
eco:b2975
PATRICifig|1411691.4.peg.3756

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2818

Phylogenomic databases

eggNOGiENOG4105DAA Bacteria
COG1620 LUCA
HOGENOMiCLU_021628_0_0_6
InParanoidiQ46839
KOiK02550
PhylomeDBiQ46839

Enzyme and pathway databases

BioCyciEcoCyc:B2975-MONOMER
ECOL316407:JW2942-MONOMER
MetaCyc:B2975-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q46839

Family and domain databases

InterProiView protein in InterPro
IPR003804 Lactate_perm
PANTHERiPTHR30003 PTHR30003, 1 hit
PfamiView protein in Pfam
PF02652 Lactate_perm, 1 hit
TIGRFAMsiTIGR00795 lctP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLCA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q46839
Secondary accession number(s): Q2M9M1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 26, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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