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Entry version 130 (07 Oct 2020)
Sequence version 2 (23 Nov 2004)
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Protein

Guanine/hypoxanthine permease GhxQ

Gene

ghxQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High-affinity transporter for guanine and hypoxanthine.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.8 µM for guanine1 Publication
  2. KM=23.2 µM for hypoxanthine1 Publication
  1. Vmax=3.4 nmol/min/mg enzyme with guanine as substrate1 Publication
  2. Vmax=13.8 nmol/min/mg enzyme with hypoxanthine as substrate1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • guanine transmembrane transporter activity Source: EcoCyc
  • purine nucleobase transmembrane transporter activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:G7504-MONOMER
MetaCyc:G7504-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.40.7.7, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanine/hypoxanthine permease GhxQ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ghxQ
Synonyms:ygfQ, ygfR
Ordered Locus Names:b4464, JW5467
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 55HelicalSequence analysisAdd BLAST24
Topological domaini56 – 65PeriplasmicSequence analysis10
Transmembranei66 – 84HelicalSequence analysisAdd BLAST19
Topological domaini85 – 86CytoplasmicSequence analysis2
Transmembranei87 – 103Discontinuously helicalSequence analysisAdd BLAST17
Topological domaini104 – 115PeriplasmicSequence analysisAdd BLAST12
Transmembranei116 – 135HelicalSequence analysisAdd BLAST20
Topological domaini136 – 147CytoplasmicSequence analysisAdd BLAST12
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 186PeriplasmicSequence analysisAdd BLAST18
Transmembranei187 – 204HelicalSequence analysisAdd BLAST18
Topological domaini205 – 208CytoplasmicSequence analysis4
Transmembranei209 – 228HelicalSequence analysisAdd BLAST20
Topological domaini229 – 260PeriplasmicSequence analysisAdd BLAST32
Transmembranei261 – 289HelicalSequence analysisAdd BLAST29
Topological domaini290 – 302CytoplasmicSequence analysisAdd BLAST13
Transmembranei303 – 318HelicalSequence analysisAdd BLAST16
Topological domaini319 – 320PeriplasmicSequence analysis2
Transmembranei321 – 336Discontinuously helicalSequence analysisAdd BLAST16
Topological domaini337 – 340CytoplasmicSequence analysis4
Transmembranei341 – 355HelicalSequence analysisAdd BLAST15
Topological domaini356 – 366PeriplasmicSequence analysisAdd BLAST11
Transmembranei367 – 386HelicalSequence analysisAdd BLAST20
Topological domaini387 – 391CytoplasmicSequence analysis5
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei392 – 427Discontinuously helicalSequence analysisAdd BLAST36
Topological domaini428 – 455CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001693581 – 455Guanine/hypoxanthine permease GhxQAdd BLAST455

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q46817

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q46817

PRoteomics IDEntifications database

More...
PRIDEi
Q46817

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4259228, 165 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b4464

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2252, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024508_0_1_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q46817

KEGG Orthology (KO)

More...
KOi
K06901

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q46817

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006043, Xant/urac/vitC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00860, Xan_ur_permease, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q46817-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGDILQTPD APKPQGALDN YFKITARGST VRQEVLAGLT TFLAMVYSVI
60 70 80 90 100
VVPGMLGKAG FPPAAVFVAT CLVAGFGSLL MGLWANLPMA IGCAISLTAF
110 120 130 140 150
TAFSLVLGQQ ISVPVALGAV FLMGVIFTAI SVTGVRTWIL RNLPMGIAHG
160 170 180 190 200
TGIGIGLFLL LIAANGVGMV IKNPIEGLPV ALGAFTSFPV MMSLLGLAVI
210 220 230 240 250
FGLEKCRVPG GILLVIIAIS IIGLIFDPAV KYHGLVAMPS LTGEDGKSLI
260 270 280 290 300
FSLDIMGALQ PTVLPSVLAL VMTAVFDATG TIRAVAGQAN LLDKDNQIIN
310 320 330 340 350
GGKALTSDSV SSIFSGLVGA APAAVYIESA AGTAAGGKTG LTATVVGALF
360 370 380 390 400
LLILFLSPLS FLIPGYATAP ALMYVGLLML SNVSKLDFND FIDAMAGLVC
410 420 430 440 450
AVFIVLTCNI VTGIMLGFVT LVVGRVFARE WQKLNIGTVI ITAALVAFYA

GGWAI
Length:455
Mass (Da):46,758
Last modified:November 23, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB56EDA4AAA01C797
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA83065 differs from that shown. Reason: Frameshift. Produces two separate ORFs (ygfQ and ygfR).Curated
The sequence AAA83066 differs from that shown. Reason: Frameshift. Produces two separate ORFs (ygfQ and ygfR).Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U28375 Genomic DNA Translation: AAA83065.1 Frameshift.
U28375 Genomic DNA Translation: AAA83066.1 Frameshift.
U00096 Genomic DNA Translation: AAT48153.1
AP009048 Genomic DNA Translation: BAE76950.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D65072
E65072

NCBI Reference Sequences

More...
RefSeqi
WP_000012163.1, NZ_STEB01000001.1
YP_026186.1, NC_000913.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAT48153; AAT48153; b4464
BAE76950; BAE76950; BAE76950

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2847748

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5467
eco:b4464

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3850

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA Translation: AAA83065.1 Frameshift.
U28375 Genomic DNA Translation: AAA83066.1 Frameshift.
U00096 Genomic DNA Translation: AAT48153.1
AP009048 Genomic DNA Translation: BAE76950.1
PIRiD65072
E65072
RefSeqiWP_000012163.1, NZ_STEB01000001.1
YP_026186.1, NC_000913.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4259228, 165 interactors
STRINGi511145.b4464

Protein family/group databases

TCDBi2.A.40.7.7, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

Proteomic databases

jPOSTiQ46817
PaxDbiQ46817
PRIDEiQ46817

Genome annotation databases

EnsemblBacteriaiAAT48153; AAT48153; b4464
BAE76950; BAE76950; BAE76950
GeneIDi2847748
KEGGiecj:JW5467
eco:b4464
PATRICifig|1411691.4.peg.3850

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2879

Phylogenomic databases

eggNOGiCOG2252, Bacteria
HOGENOMiCLU_024508_0_1_6
InParanoidiQ46817
KOiK06901
PhylomeDBiQ46817

Enzyme and pathway databases

BioCyciEcoCyc:G7504-MONOMER
MetaCyc:G7504-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q46817

Family and domain databases

InterProiView protein in InterPro
IPR006043, Xant/urac/vitC
PfamiView protein in Pfam
PF00860, Xan_ur_permease, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGHXQ_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q46817
Secondary accession number(s): Q2M9V6, Q46818, Q6BF61
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 23, 2004
Last modified: October 7, 2020
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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