The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q46802 (UACR_ECOLI)
Protein
Putative uric acid sigma-54-dependent transcriptional regulator UacR
Gene
uacR
Organism
Escherichia coli (strain K12)
Status
Functioni
Essential for both formate-dependent and formate-independent uric acid degradation. May be directly involved in the transcription of uacF in response to hypoxanthine, xanthine, and uric acid.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 300 – 307 | ATPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 364 – 373 | ATPPROSITE-ProRule annotation | 10 | |
DNA bindingi | 567 – 585 | H-T-H motifBy similarityAdd BLAST | 19 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
- urate catabolic process Source: EcoCyc
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G7488-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Putative uric acid sigma-54-dependent transcriptional regulator UacRCuratedAlternative name(s): Uric acid regulator1 Publication |
Gene namesi | Name:uacR1 Publication Synonyms:ygeV Ordered Locus Names:b2869, JW2837 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Deletion of the gene abolishes urate-degrading activity.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081380 | 1 – 592 | Putative uric acid sigma-54-dependent transcriptional regulator UacRAdd BLAST | 592 |
Proteomic databases
jPOSTi | Q46802 |
PaxDbi | Q46802 |
PRIDEi | Q46802 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261521, 20 interactors 851647, 4 interactors |
DIPi | DIP-12157N |
IntActi | Q46802, 15 interactors |
STRINGi | 511145.b2869 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 158 – 229 | PASPROSITE-ProRule annotationAdd BLAST | 72 | |
Domaini | 272 – 502 | Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST | 231 |
Phylogenomic databases
eggNOGi | COG3829, Bacteria |
HOGENOMi | CLU_000445_8_1_6 |
InParanoidi | Q46802 |
OMAi | INVIPID |
PhylomeDBi | Q46802 |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR009057, Homeobox-like_sf IPR002197, HTH_Fis IPR027417, P-loop_NTPase IPR000014, PAS IPR035965, PAS-like_dom_sf IPR002078, Sigma_54_int IPR025662, Sigma_54_int_dom_ATP-bd_1 IPR025943, Sigma_54_int_dom_ATP-bd_2 IPR025944, Sigma_54_int_dom_CS |
Pfami | View protein in Pfam PF02954, HTH_8, 1 hit PF13188, PAS_8, 1 hit PF00158, Sigma54_activat, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF52540, SSF52540, 1 hit SSF55785, SSF55785, 1 hit |
PROSITEi | View protein in PROSITE PS50112, PAS, 1 hit PS00675, SIGMA54_INTERACT_1, 1 hit PS00676, SIGMA54_INTERACT_2, 1 hit PS00688, SIGMA54_INTERACT_3, 1 hit PS50045, SIGMA54_INTERACT_4, 1 hit |
i Sequence
Sequence statusi: Complete.
Q46802-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELATTQSVL MQIQPTIQRF ARMLASVLQL EVEIVDENLC RVAGTGAYGK
60 70 80 90 100
FLGRQLSGNS RLLRHVLETK TEKVVTQSRF DPLCEGCDSK ENCREKAFLG
110 120 130 140 150
TPVILQDRCV GVISLIAVTH EQQEHISDNL REFSDYVRHI STIFVSKLLE
160 170 180 190 200
DQGPGDNISK IFATMIDNMD QGVLVVDDEN RVQFVNQTAL KTLGVVQNNI
210 220 230 240 250
IGKPIRFRPL TFESNFTHGH MQHIVSWDDK SELIIGQLHN IQGRQLFLMA
260 270 280 290 300
FHQSHTSFSV ANAPDEPHIE QLVGECRVMR QLKRLISRIA PSPSSVMVVG
310 320 330 340 350
ESGTGKEVVA RAIHKLSGRR NKPFIAINCA AIPEQLLESE LFGYVKGAFT
360 370 380 390 400
GASANGKTGL IQAANTGTLF LDEIGDMPLM LQAKLLRAIE AREILPIGAS
410 420 430 440 450
SPIQVDIRII SATNQNLAQF IAEGKFREDL FYRLNVIPIT LPPLRERQED
460 470 480 490 500
IELLVHYFLH LHTRRLGSVY PGIAPDVVEI LRKHRWPGNL RELSNLMEYL
510 520 530 540 550
VNVVPSGEVI DSTLLPPNLL NNGTTEQSDV TEVSEAHLSL DDAGGTALEE
560 570 580 590
MEKQMIREAL SRHNSKKQVA DELGIGIATL YRKIKKYELL NT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28375 Genomic DNA Translation: AAA83050.1 U00096 Genomic DNA Translation: AAC75907.1 AP009048 Genomic DNA Translation: BAE76935.1 |
PIRi | E65070 |
RefSeqi | NP_417345.1, NC_000913.3 WP_000417791.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75907; AAC75907; b2869 BAE76935; BAE76935; BAE76935 |
GeneIDi | 947320 |
KEGGi | ecj:JW2837 eco:b2869 |
PATRICi | fig|1411691.4.peg.3865 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28375 Genomic DNA Translation: AAA83050.1 U00096 Genomic DNA Translation: AAC75907.1 AP009048 Genomic DNA Translation: BAE76935.1 |
PIRi | E65070 |
RefSeqi | NP_417345.1, NC_000913.3 WP_000417791.1, NZ_LN832404.1 |
3D structure databases
AlphaFoldDBi | Q46802 |
SMRi | Q46802 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261521, 20 interactors 851647, 4 interactors |
DIPi | DIP-12157N |
IntActi | Q46802, 15 interactors |
STRINGi | 511145.b2869 |
Proteomic databases
jPOSTi | Q46802 |
PaxDbi | Q46802 |
PRIDEi | Q46802 |
Genome annotation databases
EnsemblBacteriai | AAC75907; AAC75907; b2869 BAE76935; BAE76935; BAE76935 |
GeneIDi | 947320 |
KEGGi | ecj:JW2837 eco:b2869 |
PATRICi | fig|1411691.4.peg.3865 |
Organism-specific databases
EchoBASEi | EB2864 |
Phylogenomic databases
eggNOGi | COG3829, Bacteria |
HOGENOMi | CLU_000445_8_1_6 |
InParanoidi | Q46802 |
OMAi | INVIPID |
PhylomeDBi | Q46802 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7488-MONOMER |
Miscellaneous databases
PROi | PR:Q46802 |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR009057, Homeobox-like_sf IPR002197, HTH_Fis IPR027417, P-loop_NTPase IPR000014, PAS IPR035965, PAS-like_dom_sf IPR002078, Sigma_54_int IPR025662, Sigma_54_int_dom_ATP-bd_1 IPR025943, Sigma_54_int_dom_ATP-bd_2 IPR025944, Sigma_54_int_dom_CS |
Pfami | View protein in Pfam PF02954, HTH_8, 1 hit PF13188, PAS_8, 1 hit PF00158, Sigma54_activat, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF52540, SSF52540, 1 hit SSF55785, SSF55785, 1 hit |
PROSITEi | View protein in PROSITE PS50112, PAS, 1 hit PS00675, SIGMA54_INTERACT_1, 1 hit PS00676, SIGMA54_INTERACT_2, 1 hit PS00688, SIGMA54_INTERACT_3, 1 hit PS50045, SIGMA54_INTERACT_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UACR_ECOLI | |
Accessioni | Q46802Primary (citable) accession number: Q46802 Secondary accession number(s): Q2M9X1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |