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UniProtKB - Q46802 (UACR_ECOLI)

Entry version 159 (25 May 2022)
Sequence version 1 (01 Nov 1996)
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Protein

Putative uric acid sigma-54-dependent transcriptional regulator UacR

Gene

uacR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for both formate-dependent and formate-independent uric acid degradation. May be directly involved in the transcription of uacF in response to hypoxanthine, xanthine, and uric acid.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi300 – 307ATPPROSITE-ProRule annotation8
Nucleotide bindingi364 – 373ATPPROSITE-ProRule annotation10
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi567 – 585H-T-H motifBy similarityAdd BLAST19

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • regulation of transcription, DNA-templated Source: InterPro
  • urate catabolic process Source: EcoCyc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:G7488-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative uric acid sigma-54-dependent transcriptional regulator UacRCurated
Alternative name(s):
Uric acid regulator1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:uacR1 Publication
Synonyms:ygeV
Ordered Locus Names:b2869, JW2837
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deletion of the gene abolishes urate-degrading activity.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000813801 – 592Putative uric acid sigma-54-dependent transcriptional regulator UacRAdd BLAST592

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q46802

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q46802

PRoteomics IDEntifications database

More...PRIDEi		Q46802

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261521, 20 interactors
851647, 4 interactors

Database of interacting proteins

More...DIPi		DIP-12157N

Protein interaction database and analysis system

More...IntActi		Q46802, 15 interactors

STRING: functional protein association networks

More...STRINGi		511145.b2869

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q46802

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q46802

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini158 – 229PASPROSITE-ProRule annotationAdd BLAST72
Domaini272 – 502Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST231

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG3829, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000445_8_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q46802

Identification of Orthologs from Complete Genome Data

More...OMAi		INVIPID

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q46802

Family and domain databases

Conserved Domains Database

More...CDDi		cd00130, PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR009057, Homeobox-like_sf
IPR002197, HTH_Fis
IPR027417, P-loop_NTPase
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR002078, Sigma_54_int
IPR025662, Sigma_54_int_dom_ATP-bd_1
IPR025943, Sigma_54_int_dom_ATP-bd_2
IPR025944, Sigma_54_int_dom_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02954, HTH_8, 1 hit
PF13188, PAS_8, 1 hit
PF00158, Sigma54_activat, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit
SM00091, PAS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit
SSF52540, SSF52540, 1 hit
SSF55785, SSF55785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50112, PAS, 1 hit
PS00675, SIGMA54_INTERACT_1, 1 hit
PS00676, SIGMA54_INTERACT_2, 1 hit
PS00688, SIGMA54_INTERACT_3, 1 hit
PS50045, SIGMA54_INTERACT_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q46802-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELATTQSVL MQIQPTIQRF ARMLASVLQL EVEIVDENLC RVAGTGAYGK 
        60         70         80         90        100
FLGRQLSGNS RLLRHVLETK TEKVVTQSRF DPLCEGCDSK ENCREKAFLG 
       110        120        130        140        150
TPVILQDRCV GVISLIAVTH EQQEHISDNL REFSDYVRHI STIFVSKLLE 
       160        170        180        190        200
DQGPGDNISK IFATMIDNMD QGVLVVDDEN RVQFVNQTAL KTLGVVQNNI 
       210        220        230        240        250
IGKPIRFRPL TFESNFTHGH MQHIVSWDDK SELIIGQLHN IQGRQLFLMA 
       260        270        280        290        300
FHQSHTSFSV ANAPDEPHIE QLVGECRVMR QLKRLISRIA PSPSSVMVVG 
       310        320        330        340        350
ESGTGKEVVA RAIHKLSGRR NKPFIAINCA AIPEQLLESE LFGYVKGAFT 
       360        370        380        390        400
GASANGKTGL IQAANTGTLF LDEIGDMPLM LQAKLLRAIE AREILPIGAS 
       410        420        430        440        450
SPIQVDIRII SATNQNLAQF IAEGKFREDL FYRLNVIPIT LPPLRERQED 
       460        470        480        490        500
IELLVHYFLH LHTRRLGSVY PGIAPDVVEI LRKHRWPGNL RELSNLMEYL 
       510        520        530        540        550
VNVVPSGEVI DSTLLPPNLL NNGTTEQSDV TEVSEAHLSL DDAGGTALEE 
       560        570        580        590 
MEKQMIREAL SRHNSKKQVA DELGIGIATL YRKIKKYELL NT
Length:592
Mass (Da):66,096
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FA13B60A4AB9DDD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U28375 Genomic DNA Translation: AAA83050.1
U00096 Genomic DNA Translation: AAC75907.1
AP009048 Genomic DNA Translation: BAE76935.1

Protein sequence database of the Protein Information Resource

More...PIRi		E65070

NCBI Reference Sequences

More...RefSeqi		NP_417345.1, NC_000913.3
WP_000417791.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75907; AAC75907; b2869
BAE76935; BAE76935; BAE76935

Database of genes from NCBI RefSeq genomes

More...GeneIDi		947320

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW2837
eco:b2869

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.3865

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA Translation: AAA83050.1
U00096 Genomic DNA Translation: AAC75907.1
AP009048 Genomic DNA Translation: BAE76935.1
PIRiE65070
RefSeqiNP_417345.1, NC_000913.3
WP_000417791.1, NZ_LN832404.1

3D structure databases

AlphaFoldDBiQ46802
SMRiQ46802
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261521, 20 interactors
851647, 4 interactors
DIPiDIP-12157N
IntActiQ46802, 15 interactors
STRINGi511145.b2869

Proteomic databases

jPOSTiQ46802
PaxDbiQ46802
PRIDEiQ46802

Genome annotation databases

EnsemblBacteriaiAAC75907; AAC75907; b2869
BAE76935; BAE76935; BAE76935
GeneIDi947320
KEGGiecj:JW2837
eco:b2869
PATRICifig|1411691.4.peg.3865

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB2864

Phylogenomic databases

eggNOGiCOG3829, Bacteria
HOGENOMiCLU_000445_8_1_6
InParanoidiQ46802
OMAiINVIPID
PhylomeDBiQ46802

Enzyme and pathway databases

BioCyciEcoCyc:G7488-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q46802

Family and domain databases

CDDicd00130, PAS, 1 hit
Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR009057, Homeobox-like_sf
IPR002197, HTH_Fis
IPR027417, P-loop_NTPase
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR002078, Sigma_54_int
IPR025662, Sigma_54_int_dom_ATP-bd_1
IPR025943, Sigma_54_int_dom_ATP-bd_2
IPR025944, Sigma_54_int_dom_CS
PfamiView protein in Pfam
PF02954, HTH_8, 1 hit
PF13188, PAS_8, 1 hit
PF00158, Sigma54_activat, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00091, PAS, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF52540, SSF52540, 1 hit
SSF55785, SSF55785, 1 hit
PROSITEiView protein in PROSITE
PS50112, PAS, 1 hit
PS00675, SIGMA54_INTERACT_1, 1 hit
PS00676, SIGMA54_INTERACT_2, 1 hit
PS00688, SIGMA54_INTERACT_3, 1 hit
PS50045, SIGMA54_INTERACT_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUACR_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q46802
Secondary accession number(s): Q2M9X1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 25, 2022
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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