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Protein

Aldehyde oxidoreductase

Gene

mop

Organism
Desulfovibrio gigas
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

An aldehyde + H2O + acceptor = a carboxylate + reduced acceptor.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Iron-sulfur 1 (2Fe-2S)1 Publication1
Metal bindingi45Iron-sulfur 1 (2Fe-2S)1 Publication1
Metal bindingi48Iron-sulfur 1 (2Fe-2S)1 Publication1
Metal bindingi60Iron-sulfur 1 (2Fe-2S)1 Publication1
Metal bindingi100Iron-sulfur 2 (2Fe-2S)1 Publication1
Metal bindingi103Iron-sulfur 2 (2Fe-2S)1 Publication1
Metal bindingi137Iron-sulfur 2 (2Fe-2S)1 Publication1
Metal bindingi139Iron-sulfur 2 (2Fe-2S)1 Publication1
Metal bindingi653Molybdenum1
Metal bindingi869Molybdenum1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BRENDAi1.2.99.7 1907
SABIO-RKiQ46509

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde oxidoreductase (EC:1.2.99.7)
Alternative name(s):
Molybdenum iron sulfur protein
Gene namesi
Name:mop
OrganismiDesulfovibrio gigas
Taxonomic identifieri879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Pathology & Biotechi

Chemistry databases

DrugBankiDB02325 Isopropyl Alcohol
DB02137 Molybdenum Cofactor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001661021 – 907Aldehyde oxidoreductaseAdd BLAST907

Proteomic databases

PRIDEiQ46509

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1907
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ46509
SMRiQ46509
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ46509

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 792Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the xanthine dehydrogenase family.Curated

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR002888 2Fe-2S-bd
IPR036884 2Fe-2S-bd_dom_sf
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR000674 Ald_Oxase/Xan_DH_a/b
IPR036856 Ald_Oxase/Xan_DH_a/b_sf
IPR008274 AldOxase/xan_DH_Mopterin-bd
IPR037165 AldOxase/xan_DH_Mopterin-bd_sf
IPR012675 Beta-grasp_dom_sf
PfamiView protein in Pfam
PF01315 Ald_Xan_dh_C, 1 hit
PF02738 Ald_Xan_dh_C2, 1 hit
PF00111 Fer2, 1 hit
PF01799 Fer2_2, 1 hit
SMARTiView protein in SMART
SM01008 Ald_Xan_dh_C, 1 hit
SUPFAMiSSF47741 SSF47741, 1 hit
SSF54292 SSF54292, 1 hit
SSF54665 SSF54665, 1 hit
SSF56003 SSF56003, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q46509-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQKVITVNG IEQNLFVDAE ALLSDVLRQQ LGLTGVKVGC EQGQCGACSV
60 70 80 90 100
ILDGKVVRAC VTKMKRVADG AQITTIEGVG QPENLHPLQK AWVLHGGAQC
110 120 130 140 150
GFCSPGFIVS AKGLLDTNAD PSREDVRDWF QKHRNACRCT GYKPLVDAVM
160 170 180 190 200
DAAAVINGKK PETDLEFKMP ADGRIWGSKY PRPTAVAKVT GTLDYGADLG
210 220 230 240 250
LKMPAGTLHL AMVQAKVSHA NIKGIDTSEA LTMPGVHSVI THKDVKGKNR
260 270 280 290 300
ITGLITFPTN KGDGWDRPIL CDEKVFQYGD CIALVCADSE ANARAAAEKV
310 320 330 340 350
KVDLEELPAY MSGPAAAAED AIEIHPGTPN VYFEQPIVKG EDTGPIFASA
360 370 380 390 400
DVTVEGDFYV GRQPHMPIEP DVAFAYMGDD GKCYIHSKSI GVHLHLYMIA
410 420 430 440 450
PGVGLEPDQL VLVANPMGGT FGYKFSPTSE ALVAVAAMAT GRPVHLRYNY
460 470 480 490 500
QQQQQYTGKR SPWEMNVKFA AKKDGTLLAM ESDWLVDHGP YSEFGDLLTL
510 520 530 540 550
RGAQFIGAGY NIPNIRGLGR TVATNHVWGS AFRGYGAPQS MFASECLMDM
560 570 580 590 600
LAEKLGMDPL ELRYKNAYRP GDTNPTGQEP EVFSLPDMID QLRPKYQAAL
610 620 630 640 650
EKAQKESTAT HKKGVGISIG VYGSGLDGPD ASEAWAELNA DGTITVHTAW
660 670 680 690 700
EDHGQGADIG CVGTAHEALR PMGVAPEKIK FTWPNTATTP NSGPSGGSRQ
710 720 730 740 750
QVMTGNAIRV ACENLLKACE KPGGGYYTYD ELKAADKPTK ITGNWTASGA
760 770 780 790 800
THCDAVTGLG KPFVVYMYGV FMAEVTVDVA TGQTTVDGMT LMADLGSLCN
810 820 830 840 850
QLATDGQIYG GLAQGIGLAL SEDFEDIKKH ATLVGAGFPF IKQIPDKLDI
860 870 880 890 900
VYVNHPRPDG PFGASGVGEL PLTSPHAAII NAIKSATGVR IYRLPAYPEK

VLEALKA
Length:907
Mass (Da):97,035
Last modified:November 1, 1996 - v1
Checksum:i898E7EEF708A64DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77222 Genomic DNA Translation: CAA54439.1
PIRiA57429

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77222 Genomic DNA Translation: CAA54439.1
PIRiA57429

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SIJX-ray2.30A1-907[»]
1VLBX-ray1.28A1-907[»]
3FAHX-ray1.72A1-907[»]
3FC4X-ray1.79A1-907[»]
3L4PX-ray1.45A1-907[»]
4C7YX-ray1.57A1-907[»]
4C7ZX-ray1.55A1-907[»]
4C80X-ray1.50A1-907[»]
4US8X-ray1.49A1-907[»]
4US9X-ray1.40A1-907[»]
4USAX-ray1.13A1-907[»]
ProteinModelPortaliQ46509
SMRiQ46509
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB02325 Isopropyl Alcohol
DB02137 Molybdenum Cofactor

Proteomic databases

PRIDEiQ46509

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.2.99.7 1907
SABIO-RKiQ46509

Miscellaneous databases

EvolutionaryTraceiQ46509

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR002888 2Fe-2S-bd
IPR036884 2Fe-2S-bd_dom_sf
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR000674 Ald_Oxase/Xan_DH_a/b
IPR036856 Ald_Oxase/Xan_DH_a/b_sf
IPR008274 AldOxase/xan_DH_Mopterin-bd
IPR037165 AldOxase/xan_DH_Mopterin-bd_sf
IPR012675 Beta-grasp_dom_sf
PfamiView protein in Pfam
PF01315 Ald_Xan_dh_C, 1 hit
PF02738 Ald_Xan_dh_C2, 1 hit
PF00111 Fer2, 1 hit
PF01799 Fer2_2, 1 hit
SMARTiView protein in SMART
SM01008 Ald_Xan_dh_C, 1 hit
SUPFAMiSSF47741 SSF47741, 1 hit
SSF54292 SSF54292, 1 hit
SSF54665 SSF54665, 1 hit
SSF56003 SSF56003, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOP_DESGI
AccessioniPrimary (citable) accession number: Q46509
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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