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UniProtKB - Q46509 (MOP_MEGGA)
Protein
Aldehyde oxidoreductase
Gene
mop
Organism
Megalodesulfovibrio gigas (Desulfovibrio gigas)
Status
Functioni
Catalytic activityi
- EC:1.2.99.7
Cofactori
Protein has several cofactor binding sites:- Mo-molybdopterin cytosine dinucleotideNote: Binds 1 Mo-molybdopterin cytosine dinucleotide (Mo-MCD) cofactor per subunit.
- [2Fe-2S] clusterNote: Binds 2 [2Fe-2S] clusters per subunit.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 40 | Iron-sulfur (2Fe-2S) 11 Publication | 1 | |
Metal bindingi | 45 | Iron-sulfur (2Fe-2S) 11 Publication | 1 | |
Metal bindingi | 48 | Iron-sulfur (2Fe-2S) 11 Publication | 1 | |
Metal bindingi | 60 | Iron-sulfur (2Fe-2S) 11 Publication | 1 | |
Metal bindingi | 100 | Iron-sulfur (2Fe-2S) 21 Publication | 1 | |
Metal bindingi | 103 | Iron-sulfur (2Fe-2S) 21 Publication | 1 | |
Metal bindingi | 137 | Iron-sulfur (2Fe-2S) 21 Publication | 1 | |
Metal bindingi | 139 | Iron-sulfur (2Fe-2S) 21 Publication | 1 | |
Metal bindingi | 653 | Molybdenum (Mo-molybdopterin cytosine dinucleotide metal ligand) | 1 | |
Metal bindingi | 869 | Molybdenum (Mo-molybdopterin cytosine dinucleotide metal ligand) | 1 |
GO - Molecular functioni
- 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
- aldehyde dehydrogenase (FAD-independent) activity Source: UniProtKB-EC
- iron ion binding Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | 2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD |
Enzyme and pathway databases
BRENDAi | 1.2.99.7, 1907 |
SABIO-RKi | Q46509 |
Names & Taxonomyi
Protein namesi | Recommended name: Aldehyde oxidoreductase (EC:1.2.99.7)Alternative name(s): Molybdenum iron sulfur protein |
Gene namesi | Name:mop |
Organismi | Megalodesulfovibrio gigas (Desulfovibrio gigas) |
Taxonomic identifieri | 879 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Megalodesulfovibrio |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000166102 | 1 – 907 | Aldehyde oxidoreductaseAdd BLAST | 907 |
Proteomic databases
PRIDEi | Q46509 |
Interactioni
Subunit structurei
Homodimer.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q46509 |
SMRi | Q46509 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q46509 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 79 | 2Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST | 78 |
Sequence similaritiesi
Belongs to the xanthine dehydrogenase family.Curated
Phylogenomic databases
OMAi | CTHNPLG |
Family and domain databases
CDDi | cd00207, fer2, 1 hit |
Gene3Di | 3.10.20.30, 1 hit |
InterProi | View protein in InterPro IPR002888, 2Fe-2S-bd IPR036884, 2Fe-2S-bd_dom_sf IPR036010, 2Fe-2S_ferredoxin-like_sf IPR001041, 2Fe-2S_ferredoxin-type IPR006058, 2Fe2S_fd_BS IPR000674, Ald_Oxase/Xan_DH_a/b IPR036856, Ald_Oxase/Xan_DH_a/b_sf IPR016208, Ald_Oxase/xanthine_DH IPR008274, AldOxase/xan_DH_Mopterin-bd IPR037165, AldOxase/xan_DH_Mopterin-bd_sf IPR012675, Beta-grasp_dom_sf |
PANTHERi | PTHR11908, PTHR11908, 2 hits |
Pfami | View protein in Pfam PF01315, Ald_Xan_dh_C, 1 hit PF02738, Ald_Xan_dh_C2, 1 hit PF00111, Fer2, 1 hit PF01799, Fer2_2, 1 hit |
SMARTi | View protein in SMART SM01008, Ald_Xan_dh_C, 1 hit |
SUPFAMi | SSF47741, SSF47741, 1 hit SSF54292, SSF54292, 1 hit SSF54665, SSF54665, 1 hit SSF56003, SSF56003, 1 hit |
PROSITEi | View protein in PROSITE PS00197, 2FE2S_FER_1, 1 hit PS51085, 2FE2S_FER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q46509-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIQKVITVNG IEQNLFVDAE ALLSDVLRQQ LGLTGVKVGC EQGQCGACSV
60 70 80 90 100
ILDGKVVRAC VTKMKRVADG AQITTIEGVG QPENLHPLQK AWVLHGGAQC
110 120 130 140 150
GFCSPGFIVS AKGLLDTNAD PSREDVRDWF QKHRNACRCT GYKPLVDAVM
160 170 180 190 200
DAAAVINGKK PETDLEFKMP ADGRIWGSKY PRPTAVAKVT GTLDYGADLG
210 220 230 240 250
LKMPAGTLHL AMVQAKVSHA NIKGIDTSEA LTMPGVHSVI THKDVKGKNR
260 270 280 290 300
ITGLITFPTN KGDGWDRPIL CDEKVFQYGD CIALVCADSE ANARAAAEKV
310 320 330 340 350
KVDLEELPAY MSGPAAAAED AIEIHPGTPN VYFEQPIVKG EDTGPIFASA
360 370 380 390 400
DVTVEGDFYV GRQPHMPIEP DVAFAYMGDD GKCYIHSKSI GVHLHLYMIA
410 420 430 440 450
PGVGLEPDQL VLVANPMGGT FGYKFSPTSE ALVAVAAMAT GRPVHLRYNY
460 470 480 490 500
QQQQQYTGKR SPWEMNVKFA AKKDGTLLAM ESDWLVDHGP YSEFGDLLTL
510 520 530 540 550
RGAQFIGAGY NIPNIRGLGR TVATNHVWGS AFRGYGAPQS MFASECLMDM
560 570 580 590 600
LAEKLGMDPL ELRYKNAYRP GDTNPTGQEP EVFSLPDMID QLRPKYQAAL
610 620 630 640 650
EKAQKESTAT HKKGVGISIG VYGSGLDGPD ASEAWAELNA DGTITVHTAW
660 670 680 690 700
EDHGQGADIG CVGTAHEALR PMGVAPEKIK FTWPNTATTP NSGPSGGSRQ
710 720 730 740 750
QVMTGNAIRV ACENLLKACE KPGGGYYTYD ELKAADKPTK ITGNWTASGA
760 770 780 790 800
THCDAVTGLG KPFVVYMYGV FMAEVTVDVA TGQTTVDGMT LMADLGSLCN
810 820 830 840 850
QLATDGQIYG GLAQGIGLAL SEDFEDIKKH ATLVGAGFPF IKQIPDKLDI
860 870 880 890 900
VYVNHPRPDG PFGASGVGEL PLTSPHAAII NAIKSATGVR IYRLPAYPEK
VLEALKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77222 Genomic DNA Translation: CAA54439.1 |
PIRi | A57429 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77222 Genomic DNA Translation: CAA54439.1 |
PIRi | A57429 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SIJ | X-ray | 2.30 | A | 1-907 | [»] | |
1VLB | X-ray | 1.28 | A | 1-907 | [»] | |
3FAH | X-ray | 1.72 | A | 1-907 | [»] | |
3FC4 | X-ray | 1.79 | A | 1-907 | [»] | |
3L4P | X-ray | 1.45 | A | 1-907 | [»] | |
4C7Y | X-ray | 1.57 | A | 1-907 | [»] | |
4C7Z | X-ray | 1.55 | A | 1-907 | [»] | |
4C80 | X-ray | 1.50 | A | 1-907 | [»] | |
4US8 | X-ray | 1.49 | A | 1-907 | [»] | |
4US9 | X-ray | 1.40 | A | 1-907 | [»] | |
4USA | X-ray | 1.13 | A | 1-907 | [»] | |
AlphaFoldDBi | Q46509 | |||||
SMRi | Q46509 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
DrugBanki | DB02137, Molybdenum cofactor |
Proteomic databases
PRIDEi | Q46509 |
Phylogenomic databases
OMAi | CTHNPLG |
Enzyme and pathway databases
BRENDAi | 1.2.99.7, 1907 |
SABIO-RKi | Q46509 |
Miscellaneous databases
EvolutionaryTracei | Q46509 |
Family and domain databases
CDDi | cd00207, fer2, 1 hit |
Gene3Di | 3.10.20.30, 1 hit |
InterProi | View protein in InterPro IPR002888, 2Fe-2S-bd IPR036884, 2Fe-2S-bd_dom_sf IPR036010, 2Fe-2S_ferredoxin-like_sf IPR001041, 2Fe-2S_ferredoxin-type IPR006058, 2Fe2S_fd_BS IPR000674, Ald_Oxase/Xan_DH_a/b IPR036856, Ald_Oxase/Xan_DH_a/b_sf IPR016208, Ald_Oxase/xanthine_DH IPR008274, AldOxase/xan_DH_Mopterin-bd IPR037165, AldOxase/xan_DH_Mopterin-bd_sf IPR012675, Beta-grasp_dom_sf |
PANTHERi | PTHR11908, PTHR11908, 2 hits |
Pfami | View protein in Pfam PF01315, Ald_Xan_dh_C, 1 hit PF02738, Ald_Xan_dh_C2, 1 hit PF00111, Fer2, 1 hit PF01799, Fer2_2, 1 hit |
SMARTi | View protein in SMART SM01008, Ald_Xan_dh_C, 1 hit |
SUPFAMi | SSF47741, SSF47741, 1 hit SSF54292, SSF54292, 1 hit SSF54665, SSF54665, 1 hit SSF56003, SSF56003, 1 hit |
PROSITEi | View protein in PROSITE PS00197, 2FE2S_FER_1, 1 hit PS51085, 2FE2S_FER_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MOP_MEGGA | |
Accessioni | Q46509Primary (citable) accession number: Q46509 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families