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Entry version 131 (17 Jun 2020)
Sequence version 2 (16 Apr 2014)
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Protein

Protein mono-ADP-ribosyltransferase PARP15

Gene

PARP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:16061477, PubMed:25043379, PubMed:25635049). Acts as a negative regulator of transcription (PubMed:16061477).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei331SubstrateCombined sources1 Publication1
Binding sitei335Substrate; via amide nitrogenCombined sources1 Publication1
Binding sitei449SubstrateCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandNAD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein mono-ADP-ribosyltransferase PARP15Curated (EC:2.4.2.-2 Publications)
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 71 Publication
Short name:
ARTD71 Publication
B-aggressive lymphoma protein 31 Publication
Poly [ADP-ribose] polymerase 15
Short name:
PARP-15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PARP151 PublicationImported
Synonyms:BAL31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173200.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26876 PARP15

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612066 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q460N3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi559H → Y: Abolishes catalytic activity. 1 Publication1
Mutagenesisi560G → A: Slightly reduces catalytic activity. Abolishes activity; when associated with Y-559 and C-604. 1 Publication1
Mutagenesisi604Y → C: Reduces catalytic activity 20-fold. Abolishes activity; when associated with Y-559 and A-560. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
165631

Open Targets

More...
OpenTargetsi
ENSG00000173200

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134905094

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q460N3 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2176778

Drug and drug target database

More...
DrugBanki
DB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE

DrugCentral

More...
DrugCentrali
Q460N3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PARP15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116248564

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002524361 – 678Protein mono-ADP-ribosyltransferase PARP15Add BLAST678

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q460N3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q460N3

PeptideAtlas

More...
PeptideAtlasi
Q460N3

PRoteomics IDEntifications database

More...
PRIDEi
Q460N3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61928 [Q460N3-1]
61929 [Q460N3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q460N3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q460N3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173200 Expressed in spleen and 95 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q460N3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q460N3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000173200 Tissue enhanced (intestine, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127917, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q460N3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417214

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q460N3

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q460N3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1678
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q460N3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q460N3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 267Macro 1PROSITE-ProRule annotationAdd BLAST190
Domaini293 – 464Macro 2PROSITE-ProRule annotationAdd BLAST172
Domaini482 – 678PARP catalyticPROSITE-ProRule annotationAdd BLAST197

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni312 – 313Substrate bindingCombined sources1 Publication2
Regioni324 – 325Substrate bindingCombined sources1 Publication2
Regioni409 – 413Substrate bindingCombined sources1 Publication5

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2633 Eukaryota
COG2110 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163672

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q460N3

KEGG Orthology (KO)

More...
KOi
K15261

Identification of Orthologs from Complete Genome Data

More...
OMAi
NKARIPM

Database of Orthologous Groups

More...
OrthoDBi
681829at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q460N3

TreeFam database of animal gene trees

More...
TreeFami
TF316072

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002589 Macro_dom
IPR034401 PARP15
IPR012317 Poly(ADP-ribose)pol_cat_dom

The PANTHER Classification System

More...
PANTHERi
PTHR14453:SF92 PTHR14453:SF92, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01661 Macro, 2 hits
PF00644 PARP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506 A1pp, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51154 MACRO, 2 hits
PS51059 PARP_CATALYTIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q460N3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPGPLPAA ALSPGAPTPR ELMHGVAGVT SRAGRDREAG SVLPAGNRGA
60 70 80 90 100
RKASRRSSSR SMSRDNKFSK KDCLSIRNVV ASIQTKEGLN LKLISGDVLY
110 120 130 140 150
IWADVIVNSV PMNLQLGGGP LSRAFLQKAG PMLQKELDDR RRETEEKVGN
160 170 180 190 200
IFMTSGCNLD CKAVLHAVAP YWNNGAETSW QIMANIIKKC LTTVEVLSFS
210 220 230 240 250
SITFPMIGTG SLQFPKAVFA KLILSEVFEY SSSTRPITSP LQEVHFLVYT
260 270 280 290 300
NDDEGCQAFL DEFTNWSRIN PNKARIPMAG DTQGVVGTVS KPCFTAYEMK
310 320 330 340 350
IGAITFQVAT GDIATEQVDV IVNSTARTFN RKSGVSRAIL EGAGQAVESE
360 370 380 390 400
CAVLAAQPHR DFIITPGGCL KCKIIIHVPG GKDVRKTVTS VLEECEQRKY
410 420 430 440 450
TSVSLPAIGT GNAGKNPITV ADNIIDAIVD FSSQHSTPSL KTVKVVIFQP
460 470 480 490 500
ELLNIFYDSM KKRDLSASLN FQSTFSMTTC NLPEHWTDMN HQLFCMVQLE
510 520 530 540 550
PGQSEYNTIK DKFTRTCSSY AIEKIERIQN AFLWQSYQVK KRQMDIKNDH
560 570 580 590 600
KNNERLLFHG TDADSVPYVN QHGFNRSCAG KNAVSYGKGT YFAVDASYSA
610 620 630 640 650
KDTYSKPDSN GRKHMYVVRV LTGVFTKGRA GLVTPPPKNP HNPTDLFDSV
660 670
TNNTRSPKLF VVFFDNQAYP EYLITFTA
Length:678
Mass (Da):74,576
Last modified:April 16, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE299386DA4B2BF8C
GO
Isoform 2 (identifier: Q460N3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     235-256: RPITSPLQEVHFLVYTNDDEGC → MLQRIGLIFLHNIVVVSNCFYF

Show »
Length:444
Mass (Da):49,501
Checksum:i1A86C67A336419FC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZL48B7ZL48_HUMAN
Poly [ADP-ribose] polymerase
PARP15
375Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7L3C9J7L3_HUMAN
Poly [ADP-ribose] polymerase
PARP15
483Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY64451 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti42V → M in AAY64451 (PubMed:16061477).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027862337R → K. Corresponds to variant dbSNP:rs6793271Ensembl.1
Natural variantiVAR_056658521A → T. Corresponds to variant dbSNP:rs34383355Ensembl.1
Natural variantiVAR_027863628G → R. Corresponds to variant dbSNP:rs12489170Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0209711 – 234Missing in isoform 2. 2 PublicationsAdd BLAST234
Alternative sequenceiVSP_020972235 – 256RPITS…DDEGC → MLQRIGLIFLHNIVVVSNCF YF in isoform 2. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK097916 mRNA Translation: BAC05197.1
BC101703 mRNA Translation: AAI01704.1
BC101701 mRNA Translation: AAI01702.1
AC092908 Genomic DNA No translation available.
DQ063586 mRNA Translation: AAY64451.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3016.1 [Q460N3-2]
CCDS46893.1 [Q460N3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001106995.1, NM_001113523.2 [Q460N3-1]
NP_001295249.1, NM_001308320.1
NP_689828.1, NM_152615.2 [Q460N3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310366; ENSP00000308436; ENSG00000173200 [Q460N3-2]
ENST00000464300; ENSP00000417214; ENSG00000173200 [Q460N3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
165631

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:165631

UCSC genome browser

More...
UCSCi
uc003efm.3 human [Q460N3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097916 mRNA Translation: BAC05197.1
BC101703 mRNA Translation: AAI01704.1
BC101701 mRNA Translation: AAI01702.1
AC092908 Genomic DNA No translation available.
DQ063586 mRNA Translation: AAY64451.1 Different initiation.
CCDSiCCDS3016.1 [Q460N3-2]
CCDS46893.1 [Q460N3-1]
RefSeqiNP_001106995.1, NM_001113523.2 [Q460N3-1]
NP_001295249.1, NM_001308320.1
NP_689828.1, NM_152615.2 [Q460N3-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BLJX-ray2.20A/B481-678[»]
3GEYX-ray2.20A/B/C/D481-678[»]
3V2BX-ray2.20A295-470[»]
4F0EX-ray2.40A/B/C/D481-678[»]
6EK3X-ray1.60A/B481-678[»]
SMRiQ460N3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi127917, 1 interactor
IntActiQ460N3, 1 interactor
STRINGi9606.ENSP00000417214

Chemistry databases

BindingDBiQ460N3
ChEMBLiCHEMBL2176778
DrugBankiDB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE
DrugCentraliQ460N3

PTM databases

iPTMnetiQ460N3
PhosphoSitePlusiQ460N3

Polymorphism and mutation databases

BioMutaiPARP15
DMDMi116248564

Proteomic databases

MassIVEiQ460N3
PaxDbiQ460N3
PeptideAtlasiQ460N3
PRIDEiQ460N3
ProteomicsDBi61928 [Q460N3-1]
61929 [Q460N3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32915 28 antibodies

Genome annotation databases

EnsembliENST00000310366; ENSP00000308436; ENSG00000173200 [Q460N3-2]
ENST00000464300; ENSP00000417214; ENSG00000173200 [Q460N3-1]
GeneIDi165631
KEGGihsa:165631
UCSCiuc003efm.3 human [Q460N3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
165631
DisGeNETi165631
EuPathDBiHostDB:ENSG00000173200.12

GeneCards: human genes, protein and diseases

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GeneCardsi
PARP15
HGNCiHGNC:26876 PARP15
HPAiENSG00000173200 Tissue enhanced (intestine, lymphoid tissue)
MIMi612066 gene
neXtProtiNX_Q460N3
OpenTargetsiENSG00000173200
PharmGKBiPA134905094

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2633 Eukaryota
COG2110 LUCA
GeneTreeiENSGT00940000163672
InParanoidiQ460N3
KOiK15261
OMAiNKARIPM
OrthoDBi681829at2759
PhylomeDBiQ460N3
TreeFamiTF316072

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
165631 3 hits in 790 CRISPR screens
EvolutionaryTraceiQ460N3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
165631
PharosiQ460N3 Tbio

Protein Ontology

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PROi
PR:Q460N3
RNActiQ460N3 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000173200 Expressed in spleen and 95 other tissues
ExpressionAtlasiQ460N3 baseline and differential
GenevisibleiQ460N3 HS

Family and domain databases

InterProiView protein in InterPro
IPR002589 Macro_dom
IPR034401 PARP15
IPR012317 Poly(ADP-ribose)pol_cat_dom
PANTHERiPTHR14453:SF92 PTHR14453:SF92, 1 hit
PfamiView protein in Pfam
PF01661 Macro, 2 hits
PF00644 PARP, 1 hit
SMARTiView protein in SMART
SM00506 A1pp, 2 hits
PROSITEiView protein in PROSITE
PS51154 MACRO, 2 hits
PS51059 PARP_CATALYTIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAR15_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q460N3
Secondary accession number(s): J3KR47, Q8N1K3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 16, 2014
Last modified: June 17, 2020
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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