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Protein

Poly [ADP-ribose] polymerase 15

Gene

PARP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possesses ADP-ribosyltransferase activity (PubMed:16061477, PubMed:25635049). Transcriptional repressor (PubMed:16061477).2 Publications

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei331SubstrateCombined sources1 Publication1
Binding sitei335Substrate; via amide nitrogenCombined sources1 Publication1
Binding sitei449SubstrateCombined sources1 Publication1

GO - Molecular functioni

  • NAD+ ADP-ribosyltransferase activity Source: UniProtKB
  • NAD+ binding Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 15 (EC:2.4.2.301 Publication)
Short name:
PARP-15
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 7
Short name:
ARTD7
B-aggressive lymphoma protein 3
Gene namesi
Name:PARP15
Synonyms:BAL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000173200.12
HGNCiHGNC:26876 PARP15
MIMi612066 gene
neXtProtiNX_Q460N3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi559H → Y: Abolishes catalytic activity. 1 Publication1
Mutagenesisi560G → A: Slightly reduces catalytic activity. Abolishes activity; when associated with Y-559 and C-604. 1 Publication1
Mutagenesisi604Y → C: Reduces catalytic activity 20-fold. Abolishes activity; when associated with Y-559 and A-560. 1 Publication1

Organism-specific databases

DisGeNETi165631
OpenTargetsiENSG00000173200
PharmGKBiPA134905094

Chemistry databases

ChEMBLiCHEMBL2176778

Polymorphism and mutation databases

BioMutaiPARP15
DMDMi116248564

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524361 – 678Poly [ADP-ribose] polymerase 15Add BLAST678

Proteomic databases

PaxDbiQ460N3
PeptideAtlasiQ460N3
PRIDEiQ460N3
ProteomicsDBi61928
61929 [Q460N3-2]

PTM databases

iPTMnetiQ460N3
PhosphoSitePlusiQ460N3

Expressioni

Gene expression databases

BgeeiENSG00000173200 Expressed in 96 organ(s), highest expression level in spleen
CleanExiHS_PARP15
ExpressionAtlasiQ460N3 baseline and differential
GenevisibleiQ460N3 HS

Organism-specific databases

HPAiHPA035757

Interactioni

Protein-protein interaction databases

BioGridi127917, 1 interactor
IntActiQ460N3, 1 interactor
STRINGi9606.ENSP00000417214

Chemistry databases

BindingDBiQ460N3

Structurei

Secondary structure

1678
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ460N3
SMRiQ460N3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ460N3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 267Macro 1PROSITE-ProRule annotationAdd BLAST190
Domaini293 – 464Macro 2PROSITE-ProRule annotationAdd BLAST172
Domaini482 – 678PARP catalyticPROSITE-ProRule annotationAdd BLAST197

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 313Substrate bindingCombined sources1 Publication2
Regioni324 – 325Substrate bindingCombined sources1 Publication2
Regioni409 – 413Substrate bindingCombined sources1 Publication5

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2633 Eukaryota
COG2110 LUCA
GeneTreeiENSGT00760000119084
HOGENOMiHOG000026781
HOVERGENiHBG082106
InParanoidiQ460N3
KOiK15261
OMAiFPMIGTG
OrthoDBiEOG091G00EB
PhylomeDBiQ460N3
TreeFamiTF316072

Family and domain databases

InterProiView protein in InterPro
IPR002589 Macro_dom
IPR034401 PARP15
IPR012317 Poly(ADP-ribose)pol_cat_dom
PANTHERiPTHR14453:SF54 PTHR14453:SF54, 1 hit
PfamiView protein in Pfam
PF01661 Macro, 2 hits
PF00644 PARP, 1 hit
SMARTiView protein in SMART
SM00506 A1pp, 2 hits
PROSITEiView protein in PROSITE
PS51154 MACRO, 2 hits
PS51059 PARP_CATALYTIC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q460N3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPGPLPAA ALSPGAPTPR ELMHGVAGVT SRAGRDREAG SVLPAGNRGA
60 70 80 90 100
RKASRRSSSR SMSRDNKFSK KDCLSIRNVV ASIQTKEGLN LKLISGDVLY
110 120 130 140 150
IWADVIVNSV PMNLQLGGGP LSRAFLQKAG PMLQKELDDR RRETEEKVGN
160 170 180 190 200
IFMTSGCNLD CKAVLHAVAP YWNNGAETSW QIMANIIKKC LTTVEVLSFS
210 220 230 240 250
SITFPMIGTG SLQFPKAVFA KLILSEVFEY SSSTRPITSP LQEVHFLVYT
260 270 280 290 300
NDDEGCQAFL DEFTNWSRIN PNKARIPMAG DTQGVVGTVS KPCFTAYEMK
310 320 330 340 350
IGAITFQVAT GDIATEQVDV IVNSTARTFN RKSGVSRAIL EGAGQAVESE
360 370 380 390 400
CAVLAAQPHR DFIITPGGCL KCKIIIHVPG GKDVRKTVTS VLEECEQRKY
410 420 430 440 450
TSVSLPAIGT GNAGKNPITV ADNIIDAIVD FSSQHSTPSL KTVKVVIFQP
460 470 480 490 500
ELLNIFYDSM KKRDLSASLN FQSTFSMTTC NLPEHWTDMN HQLFCMVQLE
510 520 530 540 550
PGQSEYNTIK DKFTRTCSSY AIEKIERIQN AFLWQSYQVK KRQMDIKNDH
560 570 580 590 600
KNNERLLFHG TDADSVPYVN QHGFNRSCAG KNAVSYGKGT YFAVDASYSA
610 620 630 640 650
KDTYSKPDSN GRKHMYVVRV LTGVFTKGRA GLVTPPPKNP HNPTDLFDSV
660 670
TNNTRSPKLF VVFFDNQAYP EYLITFTA
Length:678
Mass (Da):74,576
Last modified:April 16, 2014 - v2
Checksum:iE299386DA4B2BF8C
GO
Isoform 2 (identifier: Q460N3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     235-256: RPITSPLQEVHFLVYTNDDEGC → MLQRIGLIFLHNIVVVSNCFYF

Show »
Length:444
Mass (Da):49,501
Checksum:i1A86C67A336419FC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZL48B7ZL48_HUMAN
Poly [ADP-ribose] polymerase
PARP15
375Annotation score:
C9J7L3C9J7L3_HUMAN
Poly [ADP-ribose] polymerase
PARP15
483Annotation score:

Sequence cautioni

The sequence AAY64451 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42V → M in AAY64451 (PubMed:16061477).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027862337R → K. Corresponds to variant dbSNP:rs6793271Ensembl.1
Natural variantiVAR_056658521A → T. Corresponds to variant dbSNP:rs34383355Ensembl.1
Natural variantiVAR_027863628G → R. Corresponds to variant dbSNP:rs12489170Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0209711 – 234Missing in isoform 2. 2 PublicationsAdd BLAST234
Alternative sequenceiVSP_020972235 – 256RPITS…DDEGC → MLQRIGLIFLHNIVVVSNCF YF in isoform 2. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097916 mRNA Translation: BAC05197.1
BC101703 mRNA Translation: AAI01704.1
BC101701 mRNA Translation: AAI01702.1
AC092908 Genomic DNA No translation available.
DQ063586 mRNA Translation: AAY64451.1 Different initiation.
CCDSiCCDS3016.1 [Q460N3-2]
CCDS46893.1 [Q460N3-1]
RefSeqiNP_001106995.1, NM_001113523.2 [Q460N3-1]
NP_001295249.1, NM_001308320.1
NP_689828.1, NM_152615.2 [Q460N3-2]
UniGeneiHs.120250

Genome annotation databases

EnsembliENST00000310366; ENSP00000308436; ENSG00000173200 [Q460N3-2]
ENST00000464300; ENSP00000417214; ENSG00000173200 [Q460N3-1]
GeneIDi165631
KEGGihsa:165631
UCSCiuc003efm.3 human [Q460N3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097916 mRNA Translation: BAC05197.1
BC101703 mRNA Translation: AAI01704.1
BC101701 mRNA Translation: AAI01702.1
AC092908 Genomic DNA No translation available.
DQ063586 mRNA Translation: AAY64451.1 Different initiation.
CCDSiCCDS3016.1 [Q460N3-2]
CCDS46893.1 [Q460N3-1]
RefSeqiNP_001106995.1, NM_001113523.2 [Q460N3-1]
NP_001295249.1, NM_001308320.1
NP_689828.1, NM_152615.2 [Q460N3-2]
UniGeneiHs.120250

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BLJX-ray2.20A/B481-678[»]
3GEYX-ray2.20A/B/C/D481-678[»]
3V2BX-ray2.20A295-470[»]
4F0EX-ray2.40A/B/C/D481-678[»]
6EK3X-ray1.60A/B481-678[»]
ProteinModelPortaliQ460N3
SMRiQ460N3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127917, 1 interactor
IntActiQ460N3, 1 interactor
STRINGi9606.ENSP00000417214

Chemistry databases

BindingDBiQ460N3
ChEMBLiCHEMBL2176778

PTM databases

iPTMnetiQ460N3
PhosphoSitePlusiQ460N3

Polymorphism and mutation databases

BioMutaiPARP15
DMDMi116248564

Proteomic databases

PaxDbiQ460N3
PeptideAtlasiQ460N3
PRIDEiQ460N3
ProteomicsDBi61928
61929 [Q460N3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310366; ENSP00000308436; ENSG00000173200 [Q460N3-2]
ENST00000464300; ENSP00000417214; ENSG00000173200 [Q460N3-1]
GeneIDi165631
KEGGihsa:165631
UCSCiuc003efm.3 human [Q460N3-1]

Organism-specific databases

CTDi165631
DisGeNETi165631
EuPathDBiHostDB:ENSG00000173200.12
GeneCardsiPARP15
H-InvDBiHIX0200519
HGNCiHGNC:26876 PARP15
HPAiHPA035757
MIMi612066 gene
neXtProtiNX_Q460N3
OpenTargetsiENSG00000173200
PharmGKBiPA134905094
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2633 Eukaryota
COG2110 LUCA
GeneTreeiENSGT00760000119084
HOGENOMiHOG000026781
HOVERGENiHBG082106
InParanoidiQ460N3
KOiK15261
OMAiFPMIGTG
OrthoDBiEOG091G00EB
PhylomeDBiQ460N3
TreeFamiTF316072

Miscellaneous databases

ChiTaRSiPARP15 human
EvolutionaryTraceiQ460N3
GenomeRNAii165631
PROiPR:Q460N3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173200 Expressed in 96 organ(s), highest expression level in spleen
CleanExiHS_PARP15
ExpressionAtlasiQ460N3 baseline and differential
GenevisibleiQ460N3 HS

Family and domain databases

InterProiView protein in InterPro
IPR002589 Macro_dom
IPR034401 PARP15
IPR012317 Poly(ADP-ribose)pol_cat_dom
PANTHERiPTHR14453:SF54 PTHR14453:SF54, 1 hit
PfamiView protein in Pfam
PF01661 Macro, 2 hits
PF00644 PARP, 1 hit
SMARTiView protein in SMART
SM00506 A1pp, 2 hits
PROSITEiView protein in PROSITE
PS51154 MACRO, 2 hits
PS51059 PARP_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAR15_HUMAN
AccessioniPrimary (citable) accession number: Q460N3
Secondary accession number(s): J3KR47, Q8N1K3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 16, 2014
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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