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Entry version 128 (11 Dec 2019)
Sequence version 1 (13 Sep 2005)
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Protein

Cytoplasmic dynein 2 heavy chain 1

Gene

Dync2h1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. According to PubMed:8666668, it may play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells.3 Publications

Miscellaneous

Mice homozygous for Dync2h1 null alleles die at approximately 12.5 dpc with abnormal brain morphology, frequent heart-looping and occasionally with polysyndactily. Cilia have abnormal morphology.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi145 – 152ATPSequence analysis8
Nucleotide bindingi1689 – 1696ATPSequence analysis8
Nucleotide bindingi1979 – 1986ATPSequence analysis8
Nucleotide bindingi2291 – 2298ATPSequence analysis8
Nucleotide bindingi2655 – 2662ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Motor protein
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5610787 Hedgehog 'off' state
R-MMU-5620924 Intraflagellar transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic dynein 2 heavy chain 1
Alternative name(s):
Cytoplasmic dynein 2 heavy chain
Dynein cytoplasmic heavy chain 2
Dynein heavy chain 11
Short name:
mDHC11
Dynein heavy chain isotype 1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dync2h1
Synonyms:Dhc1b, Dnchc2, Kiaa1997
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107736 Dync2h1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2502W → R: Loss of function. 1 Publication1
Mutagenesisi3890F → S in lln mutant; loss of function. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003187441 – 4306Cytoplasmic dynein 2 heavy chain 1Add BLAST4306

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q45VK7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q45VK7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q45VK7

PRoteomics IDEntifications database

More...
PRIDEi
Q45VK7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q45VK7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q45VK7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, lung, spleen and kidney (at protein level). Enriched in the ependymal layer lining the lateral ventricles (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at 9.5 and 10.5 dpc in the neural tube where it is enriched in rostral part.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000047193 Expressed in 209 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q45VK7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q45VK7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The cytoplasmic dynein complex 2 is probably composed by a heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000116679

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q45VK7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q45VK7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1650StemBy similarityAdd BLAST1650
Regioni1651 – 1875AAA 1By similarityAdd BLAST225
Regioni1941 – 2161AAA 2By similarityAdd BLAST221
Regioni2249 – 2505AAA 3By similarityAdd BLAST257
Regioni2617 – 2862AAA 4By similarityAdd BLAST246
Regioni2880 – 3168StalkBy similarityAdd BLAST289
Regioni3243 – 3472AAA 5By similarityAdd BLAST230
Regioni3689 – 3904AAA 6By similarityAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili669 – 696Sequence analysisAdd BLAST28
Coiled coili2896 – 2981Sequence analysisAdd BLAST86
Coiled coili3108 – 3199Sequence analysisAdd BLAST92
Coiled coili3407 – 3441Sequence analysisAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154620

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q45VK7

KEGG Orthology (KO)

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KOi
K10414

Identification of Orthologs from Complete Genome Data

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OMAi
TSWIICD

Database of Orthologous Groups

More...
OrthoDBi
26380at2759

TreeFam database of animal gene trees

More...
TreeFami
TF315251

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q45VK7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGSLGDVRK LFLFTTTQNY FGLRPELWDQ PPLSNCPEVN NFLDDGNQML
60 70 80 90 100
LRVQRSEAGL AFSNTIDFDD AKDKVLVFFK LRPEVITDGN LHNNILVSSM
110 120 130 140 150
LESPINSLYQ AVRQVFAPML LKDQEWSRNF DPKLQNLLSE LEAGLGIVLR
160 170 180 190 200
KSDTNLPKLK LKEDDTRGIL TPSDEFQFWI EQAHRGSKQI SKERASYFKE
210 220 230 240 250
LFETISREFY NLDSLSLLEV VDLVETTRDV VDDVWRQTEH DHYPESRMLH
260 270 280 290 300
LLDVIGGSFG RFVQKKLGSL KLWEDPYYLV KENLKAGISI CEQWVIVCSH
310 320 330 340 350
LTGQVWQRYV PHPWKSGKYF PETLDKLGKR LEEVLAIRTI HEKLLYFLPA
360 370 380 390 400
SEERIVCLSR VFEPFTGVNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA
410 420 430 440 450
GKLKNYISEI QDSPQQLLQA FLKYKELVKR PTISKELMLE RETLLARLGD
460 470 480 490 500
SAKDFRLDFE NRCRGIPGDP SGPLSGKNLS EVVNNIVWVR QLELKVDDTI
510 520 530 540 550
KIAEALLSDL SGFRSFHRSA EDLLDQFKLY EQEQFDDWSR EVQSGLSDSR
560 570 580 590 600
SGLCIEANSR IMELDPNDGA LKVHYSDRLV ILLREVRQLS ALGFVIPAKI
610 620 630 640 650
QQVANVAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII
660 670 680 690 700
KNSKAGSGGK SQITWDNPKE LEGYIQKLQN AAERLATENR RLRKWHTTFC
710 720 730 740 750
EKVVILMNID LLRQQQRWKD GLQELRTGLA TVAAQGFQAS DMRAWRQHWN
760 770 780 790 800
HQLYKALEHQ YQVGLEALNE NLPEINVDLT YKQGRLQFRP PFEEIRAKYY
810 820 830 840 850
REMKRFIGIP NQFKGVGEAG DESIFSVMID RNASGFLTIY SKAEDLFRRL
860 870 880 890 900
SAVLHQHKEW VVIGQVDMEA LVEKNLSTVH DWEKNFKALK IKGKEVERLP
910 920 930 940 950
SAVKVDCLNI NCSPVKTVID DLIQKLFDLL VLSLKKSIQT HIHEIDTFVT
960 970 980 990 1000
EAMKVLTVIP QSVEEIGDTN VQYSNLQDRR PEILPLFQEA EDKNRLLRTV
1010 1020 1030 1040 1050
AGGGVETVSN LRAKWDKFEL MMESHQLMIK DQIEVMKGNV KSRLQIYYQE
1060 1070 1080 1090 1100
LDKFKARWDQ LKPGDDIIET GQQNTMDQSA KSIKEKKIEF DDLEVIRKKL
1110 1120 1130 1140 1150
VDDCHHFGLE EPNFSLAYSI SKDIESCAQI WALYEEFQQG LQDMAKEDWI
1160 1170 1180 1190 1200
TYRAKIYLFE EFLINWHERL RKIEEHSVMT VKLQSEVDRY KMIIPILKYV
1210 1220 1230 1240 1250
RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTI VEKASELKDL
1260 1270 1280 1290 1300
NSRAQGEVTI REALRELDLW GVGAVFSLID YEDSQNHTIK LIKDWKDIVN
1310 1320 1330 1340 1350
QVGDNRCLLQ SLKDSPYYKG FEDKVSIWER KLAQLDEYLQ NLNHIQRKWV
1360 1370 1380 1390 1400
YLEPIFGRGA LPKEQTRFNK VDEDFRSIMM DIRKDSRVTT LTTHAGIRNT
1410 1420 1430 1440 1450
LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI LGQSTNPSVI
1460 1470 1480 1490 1500
QSHLKKLFAG INSVCFDEES KHITAMKSLE GEVVPFKSKV LLSNNVEAWL
1510 1520 1530 1540 1550
NDLALEMKQT LKQLLKECVT AGRSSQGAID PSLFPSQILC LAEQIKFTED
1560 1570 1580 1590 1600
VENAIKDHSL HQIEAQLVAK LERYTSVDTS SEDPGNSESG ILELKLKALI
1610 1620 1630 1640 1650
LDIIHNIDIV KQLNQVQVHT TDDWAWKKQV RFYMKSDHTC YVQMVDSELQ
1660 1670 1680 1690 1700
YTYEYQGNAP KLVYTPLTDK CYLTLTQAMK MGLGGNPYGP AGTGKTESVK
1710 1720 1730 1740 1750
ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF DEFNRLEEAV
1760 1770 1780 1790 1800
LSAVSMQIQT IQDALKNHRT VCELLGKEVE INANSGIFIT MNPAGKGYGG
1810 1820 1830 1840 1850
RQKLPDNLKQ LFRPVAMSRP DNDLIAEVIL YSEGFKDAKE LGRKLVAIFN
1860 1870 1880 1890 1900
LSRELLTPQQ HYDWGLRALK TVLRGSGNLL RQLKKNSTKQ DVNENHIVVQ
1910 1920 1930 1940 1950
ALRLNTMSKF TFADCTRFDA LIKDVFPGID FKEVEYDELS SALKQVFEEA
1960 1970 1980 1990 2000
NYEVIPNQMK KALELYEQLR QRTGVVIVGP SGAGKSTLWR MLRAALCKIG
2010 2020 2030 2040 2050
KVVKQYTMNP KAMPRHQLLG HIDMDTREWS DGVLTNSARQ VVREPQDVSS
2060 2070 2080 2090 2100
WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPNV NFVFETHDLS
2110 2120 2130 2140 2150
CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPLEYRSN LENWIGDYFS
2160 2170 2180 2190 2200
KALQWVLKQN DYVVETSLVG TVMNGLSHLH GCKYHDQFII NLIRGLGGNL
2210 2220 2230 2240 2250
NMKSRLEFTK EVFNWARETP PDSHRPMDTY YDCDRGQLAS YMLKKPESLT
2260 2270 2280 2290 2300
ADDFSNGHIL PVIQTPDMQR GLDYFKPWLS SDTKQPFILV GPEGCGKGML
2310 2320 2330 2340 2350
LRYAFSQLRS TEIATIHCSA QTTSRHLLQK LSQTCMVIST NTGRVYRPKD
2360 2370 2380 2390 2400
CERLVLYLKD INLPKLDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI
2410 2420 2430 2440 2450
QIVASMSAGG RLGRHKLTTR FTSIVRLCAI DYPEREQLQT IYGAYLEAVL
2460 2470 2480 2490 2500
HKNLKNHSIW GSSSKIYLLA GSMVQVYEQV RAKFTVDEYS HYFFTPCILT
2510 2520 2530 2540 2550
QWVLGLFRYD LEGGSSNHPL DYVLEIVAYE ARRLFRDKIV GVKELHLFDN
2560 2570 2580 2590 2600
ILTSVLQGDW GSDILDNMAD SFYVTWGAHH VSGGKTAPGQ PLPPHGKPLG
2610 2620 2630 2640 2650
KLTSADLKDV IKKGLIHYGR DNQNLDILLF QEVLEYMSRI DRVLSFPGGS
2660 2670 2680 2690 2700
LLLAGRSGVG RRTVTSLVSH MHGAVLFSPK ISRGYEPKQF RNDLKHVLQL
2710 2720 2730 2740 2750
AGIEAQQVVL LLEDYQFVHP TFLEMINSLL ASGEVPGLYT LEELEPLLLP
2760 2770 2780 2790 2800
LKDQASQDGF FGPVFNYFTY RIQQNLHIVL IMDSANLNFI VNCESNPALH
2810 2820 2830 2840 2850
KKCQVLWMEG WSDSSMKKIP EMLFSETDGE EKYEKKRKDE KKRNSVDPDF
2860 2870 2880 2890 2900
IKSFLLIHES CKAYGATPSR YMTFLHVYSA ISSSKKKELL KRQSHLQAGV
2910 2920 2930 2940 2950
SKLNEAKALV DELNRKAGEQ SILLRIKQDE ADSALQEITV SMQDASEQKT
2960 2970 2980 2990 3000
ELERLKQRIA EEVVKIEERK SKIDDELKEV QPLVNEAKLA VGNIRPESLS
3010 3020 3030 3040 3050
EIRSLRMPPD VIRDILEGVL RLMGIFDTSW VSMKSFLAKR GVREDIATFD
3060 3070 3080 3090 3100
ARNIPKEIRE SVEELLFKNK ASFDPKNAKR ASTAAAPLAA WVKANVQYSH
3110 3120 3130 3140 3150
VLERIQPLET EQSGLELNLK KTEDRKRKLE DLLNSVGQKV SELKEKFQSR
3160 3170 3180 3190 3200
TSEAAKLEAE VSKAQETIKA AEVLISQLDR EHRRWNAQVA EIAEELATLP
3210 3220 3230 3240 3250
KRAQLAAAFI TYLSAAPEGL RKNCLEEWTK AAGLEKFDLR RFLCTESEQL
3260 3270 3280 3290 3300
IWKSEGLPSD DLSIENALVI LQSRVCPFLI DPSSQATEWL KTHLKDSHLE
3310 3320 3330 3340 3350
VINQQDSNFI TALELAVRFG KTLIIQEMDG VEPVLYPLLR RDLVAQGPRY
3360 3370 3380 3390 3400
VVQIGDKIID YNEDFRLFLS TRNPNPFIPP DAASIVTEVN FTTTRSGLRG
3410 3420 3430 3440 3450
QLLALTIQHE KPDLEEQKTK LLQQEEDKKI QLARLEESLL ETLATSQGNI
3460 3470 3480 3490 3500
LENKDLIESL NQTKASSALI QDSLKESYKL QISLDQERDA YLPLAESASK
3510 3520 3530 3540 3550
MYFIISDLSK INNMYRFSLA SFLRLFQRAL QNKQDSENTE ERIQCLVNSL
3560 3570 3580 3590 3600
KHMVYEYICR CLFKADQLMF ALHFVRGMHP ELFQENEWDT FTGVVVGDML
3610 3620 3630 3640 3650
RKADSQQRIR DQLPSWIDQE RSWAVATLKI SLPSLYQTLC LEDGAFWRTY
3660 3670 3680 3690 3700
YHHSMCEQEF PSILAKKVSL FQQVLVVQAL RPDRLQSAMA LFACKALGLK
3710 3720 3730 3740 3750
ELSPLPLNLK RLYKETLEIE PILIIISPGA DPSQELQELA SAERSSECYH
3760 3770 3780 3790 3800
QVAMGQGQAD LAIQMLKECA RNGDWLCLKN LHLVVSWLPV LEKELNTLQP
3810 3820 3830 3840 3850
KDSFRLWLTA EVHPNFTPIL LQSSLKITYE SPPGLKKNLM RTYESWTPEQ
3860 3870 3880 3890 3900
ISKRDNIHRA HALFSLAWFH AACQERRNYI PQGWTKFYEF SLSDLRAGYH
3910 3920 3930 3940 3950
VIDRLFDGTK DVQWEFVHGL LENSIYGGRV DNYFDLRVLQ SYLKQFFNSS
3960 3970 3980 3990 4000
IIDVLNQRNK KSIFPYSISL PNSCSILDYR AVIEKLPEDD KPSFFGLPAN
4010 4020 4030 4040 4050
IARSSQRMIS SQVISQLRIL GRSVTAGCKF DREIWSNELS PVLNLWKKLN
4060 4070 4080 4090 4100
QNSNLIHQKV SPPNDRQGSP ILSFIILEQF NAIRLVQSVH QSLAALSKVI
4110 4120 4130 4140 4150
RGTTLLSSEV QKLASALLNQ KCPLTWQSRW EGPEDPLQYL RGLVARTLAI
4160 4170 4180 4190 4200
QNWVEKAEKQ VLLADTLDLS ELFHPDTFLN ALRQETARAT GCSVDSLKFV
4210 4220 4230 4240 4250
ASWKGRLQEA KLQIKISGLL LEGCSFDGNR LSENQHDSPS VSSVLPCYMG
4260 4270 4280 4290 4300
WTPQGSYGPY SPDECISLPV YTSAERERVV TNIDVPCGGN QDQWIQCGAA

LFLKNQ
Length:4,306
Mass (Da):492,339
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0899EEC8224F4B04
GO
Isoform 2 (identifier: Q45VK7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3272-3272: Q → QIIGLKSW

Show »
Length:4,313
Mass (Da):493,137
Checksum:i19AFDB18AC9303CB
GO
Isoform 3 (identifier: Q45VK7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-335: L → P
     337-4306: Missing.

Show »
Length:336
Mass (Da):38,857
Checksum:i1DFEDCF8F2CEE471
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z025D3Z025_MOUSE
Cytoplasmic dynein 2 heavy chain 1
Dync2h1
916Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QLS2F6QLS2_MOUSE
Cytoplasmic dynein 2 heavy chain 1
Dync2h1
385Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SS48A0A1L1SS48_MOUSE
Cytoplasmic dynein 2 heavy chain 1
Dync2h1
596Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SRI6A0A1L1SRI6_MOUSE
Cytoplasmic dynein 2 heavy chain 1
Dync2h1
426Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB29399 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38914 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33L → F in BAC28057 (PubMed:16141072).Curated1
Sequence conflicti1254A → P in AAS15576 (Ref. 4) Curated1
Sequence conflicti1664Y → I in CAB06063 (PubMed:9373155).Curated1
Sequence conflicti1687P → G in CAB06063 (PubMed:9373155).Curated1
Sequence conflicti1773E → D in CAB06063 (PubMed:9373155).Curated1
Sequence conflicti1864W → Y in CAB06063 (PubMed:9373155).Curated1
Sequence conflicti1866 – 1867LR → IS in CAB06063 (PubMed:9373155).Curated2
Sequence conflicti2687P → R in AAS15578 (Ref. 4) Curated1
Sequence conflicti2699Q → K in BAC38914 (PubMed:16141072).Curated1
Sequence conflicti2734E → K in AAS15578 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031284335L → P in isoform 3. 1 Publication1
Alternative sequenceiVSP_031285337 – 4306Missing in isoform 3. 1 PublicationAdd BLAST3970
Alternative sequenceiVSP_0312863272Q → QIIGLKSW in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ104402 mRNA Translation: AAZ41367.1
AK014500 mRNA Translation: BAB29399.2 Different initiation.
AK032860 mRNA Translation: BAC28057.1
AK045978 mRNA Translation: BAC32559.1
AK046538 mRNA Translation: BAC32776.1
AK083433 mRNA Translation: BAC38914.1 Different initiation.
AK084796 mRNA Translation: BAC39280.1
AC155908 Genomic DNA No translation available.
CT010499 Genomic DNA No translation available.
AY452064 mRNA Translation: AAS15576.1
AY452065 mRNA Translation: AAS15577.1
AY452066 mRNA Translation: AAS15578.1
AY452067 mRNA Translation: AAS15579.1
Z83809 mRNA Translation: CAB06063.1
AK173324 mRNA Translation: BAD32602.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40528.1 [Q45VK7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_084127.2, NM_029851.2 [Q45VK7-1]
XP_006509889.1, XM_006509826.3 [Q45VK7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000048417; ENSMUSP00000046733; ENSMUSG00000047193 [Q45VK7-1]
ENSMUST00000140466; ENSMUSP00000120007; ENSMUSG00000047193 [Q45VK7-1]
ENSMUST00000147193; ENSMUSP00000116679; ENSMUSG00000047193 [Q45VK7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
110350

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:110350

UCSC genome browser

More...
UCSCi
uc009occ.1 mouse [Q45VK7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104402 mRNA Translation: AAZ41367.1
AK014500 mRNA Translation: BAB29399.2 Different initiation.
AK032860 mRNA Translation: BAC28057.1
AK045978 mRNA Translation: BAC32559.1
AK046538 mRNA Translation: BAC32776.1
AK083433 mRNA Translation: BAC38914.1 Different initiation.
AK084796 mRNA Translation: BAC39280.1
AC155908 Genomic DNA No translation available.
CT010499 Genomic DNA No translation available.
AY452064 mRNA Translation: AAS15576.1
AY452065 mRNA Translation: AAS15577.1
AY452066 mRNA Translation: AAS15578.1
AY452067 mRNA Translation: AAS15579.1
Z83809 mRNA Translation: CAB06063.1
AK173324 mRNA Translation: BAD32602.1
CCDSiCCDS40528.1 [Q45VK7-1]
RefSeqiNP_084127.2, NM_029851.2 [Q45VK7-1]
XP_006509889.1, XM_006509826.3 [Q45VK7-2]

3D structure databases

SMRiQ45VK7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116679

PTM databases

iPTMnetiQ45VK7
PhosphoSitePlusiQ45VK7

Proteomic databases

EPDiQ45VK7
jPOSTiQ45VK7
PaxDbiQ45VK7
PRIDEiQ45VK7

Genome annotation databases

EnsembliENSMUST00000048417; ENSMUSP00000046733; ENSMUSG00000047193 [Q45VK7-1]
ENSMUST00000140466; ENSMUSP00000120007; ENSMUSG00000047193 [Q45VK7-1]
ENSMUST00000147193; ENSMUSP00000116679; ENSMUSG00000047193 [Q45VK7-2]
GeneIDi110350
KEGGimmu:110350
UCSCiuc009occ.1 mouse [Q45VK7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79659
MGIiMGI:107736 Dync2h1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00940000154620
InParanoidiQ45VK7
KOiK10414
OMAiTSWIICD
OrthoDBi26380at2759
TreeFamiTF315251

Enzyme and pathway databases

ReactomeiR-MMU-5610787 Hedgehog 'off' state
R-MMU-5620924 Intraflagellar transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dync2h1 mouse

Protein Ontology

More...
PROi
PR:Q45VK7
RNActiQ45VK7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000047193 Expressed in 209 organ(s), highest expression level in testis
ExpressionAtlasiQ45VK7 baseline and differential
GenevisibleiQ45VK7 MM

Family and domain databases

Gene3Di1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 3 hits
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYHC2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q45VK7
Secondary accession number(s): B8JJF9
, B8JJG0, O08822, Q5VI59, Q5VI60, Q5VI61, Q5VI62, Q69Z42, Q8BJL5, Q8BL87, Q8BMC7, Q8BUI9, Q8BXK5, Q9CRR8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 13, 2005
Last modified: December 11, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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