Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytoplasmic dynein 2 heavy chain 1

Gene

Dync2h1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. According to PubMed:8666668, it may play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells.3 Publications

Miscellaneous

Mice homozygous for Dync2h1 null alleles die at approximately E12.5 with abnormal brain morphology, frequent heart-looping and occasionally with polysyndactily. Cilia have abnormal morphology.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi145 – 152ATPSequence analysis8
Nucleotide bindingi1689 – 1696ATPSequence analysis8
Nucleotide bindingi1979 – 1986ATPSequence analysis8
Nucleotide bindingi2291 – 2298ATPSequence analysis8
Nucleotide bindingi2655 – 2662ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Motor protein
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-5610787 Hedgehog 'off' state
R-MMU-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 2 heavy chain 1
Alternative name(s):
Cytoplasmic dynein 2 heavy chain
Dynein cytoplasmic heavy chain 2
Dynein heavy chain 11
Short name:
mDHC11
Dynein heavy chain isotype 1B
Gene namesi
Name:Dync2h1
Synonyms:Dhc1b, Dnchc2, Kiaa1997
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107736 Dync2h1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Membrane, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2502W → R: Loss of function. 1 Publication1
Mutagenesisi3890F → S in lln mutant; loss of function. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003187441 – 4306Cytoplasmic dynein 2 heavy chain 1Add BLAST4306

Proteomic databases

PaxDbiQ45VK7
PRIDEiQ45VK7

PTM databases

iPTMnetiQ45VK7
PhosphoSitePlusiQ45VK7

Expressioni

Tissue specificityi

Detected in brain, lung, spleen and kidney (at protein level). Enriched in the ependymal layer lining the lateral ventricles (at protein level).2 Publications

Developmental stagei

Expressed at E9.5 and E10.5 in the neural tube where it is enriched in rostral part.1 Publication

Gene expression databases

BgeeiENSMUSG00000047193 Expressed in 209 organ(s), highest expression level in testis
CleanExiMM_DYNC2H1
ExpressionAtlasiQ45VK7 baseline and differential
GenevisibleiQ45VK7 MM

Interactioni

Subunit structurei

The cytoplasmic dynein complex 2 is probably composed by a heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046733

Structurei

3D structure databases

ProteinModelPortaliQ45VK7
SMRiQ45VK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 1650StemBy similarityAdd BLAST1650
Regioni1651 – 1875AAA 1By similarityAdd BLAST225
Regioni1941 – 2161AAA 2By similarityAdd BLAST221
Regioni2249 – 2505AAA 3By similarityAdd BLAST257
Regioni2617 – 2862AAA 4By similarityAdd BLAST246
Regioni2880 – 3168StalkBy similarityAdd BLAST289
Regioni3243 – 3472AAA 5By similarityAdd BLAST230
Regioni3689 – 3904AAA 6By similarityAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili669 – 696Sequence analysisAdd BLAST28
Coiled coili2896 – 2981Sequence analysisAdd BLAST86
Coiled coili3108 – 3199Sequence analysisAdd BLAST92
Coiled coili3407 – 3441Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00760000118964
HOVERGENiHBG107832
InParanoidiQ45VK7
KOiK10414
OMAiANAHRAW
OrthoDBiEOG091G0313
TreeFamiTF315251

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR011704 ATPase_dyneun-rel_AAA
IPR035706 DHC_D5
IPR026983 DHC_fam
IPR026815 DYNC2H1
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_dom
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PTHR10676:SF352 PTHR10676:SF352, 1 hit
PfamiView protein in Pfam
PF07728 AAA_5, 1 hit
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 3 hits
SUPFAMiSSF52540 SSF52540, 4 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q45VK7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGSLGDVRK LFLFTTTQNY FGLRPELWDQ PPLSNCPEVN NFLDDGNQML
60 70 80 90 100
LRVQRSEAGL AFSNTIDFDD AKDKVLVFFK LRPEVITDGN LHNNILVSSM
110 120 130 140 150
LESPINSLYQ AVRQVFAPML LKDQEWSRNF DPKLQNLLSE LEAGLGIVLR
160 170 180 190 200
KSDTNLPKLK LKEDDTRGIL TPSDEFQFWI EQAHRGSKQI SKERASYFKE
210 220 230 240 250
LFETISREFY NLDSLSLLEV VDLVETTRDV VDDVWRQTEH DHYPESRMLH
260 270 280 290 300
LLDVIGGSFG RFVQKKLGSL KLWEDPYYLV KENLKAGISI CEQWVIVCSH
310 320 330 340 350
LTGQVWQRYV PHPWKSGKYF PETLDKLGKR LEEVLAIRTI HEKLLYFLPA
360 370 380 390 400
SEERIVCLSR VFEPFTGVNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA
410 420 430 440 450
GKLKNYISEI QDSPQQLLQA FLKYKELVKR PTISKELMLE RETLLARLGD
460 470 480 490 500
SAKDFRLDFE NRCRGIPGDP SGPLSGKNLS EVVNNIVWVR QLELKVDDTI
510 520 530 540 550
KIAEALLSDL SGFRSFHRSA EDLLDQFKLY EQEQFDDWSR EVQSGLSDSR
560 570 580 590 600
SGLCIEANSR IMELDPNDGA LKVHYSDRLV ILLREVRQLS ALGFVIPAKI
610 620 630 640 650
QQVANVAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII
660 670 680 690 700
KNSKAGSGGK SQITWDNPKE LEGYIQKLQN AAERLATENR RLRKWHTTFC
710 720 730 740 750
EKVVILMNID LLRQQQRWKD GLQELRTGLA TVAAQGFQAS DMRAWRQHWN
760 770 780 790 800
HQLYKALEHQ YQVGLEALNE NLPEINVDLT YKQGRLQFRP PFEEIRAKYY
810 820 830 840 850
REMKRFIGIP NQFKGVGEAG DESIFSVMID RNASGFLTIY SKAEDLFRRL
860 870 880 890 900
SAVLHQHKEW VVIGQVDMEA LVEKNLSTVH DWEKNFKALK IKGKEVERLP
910 920 930 940 950
SAVKVDCLNI NCSPVKTVID DLIQKLFDLL VLSLKKSIQT HIHEIDTFVT
960 970 980 990 1000
EAMKVLTVIP QSVEEIGDTN VQYSNLQDRR PEILPLFQEA EDKNRLLRTV
1010 1020 1030 1040 1050
AGGGVETVSN LRAKWDKFEL MMESHQLMIK DQIEVMKGNV KSRLQIYYQE
1060 1070 1080 1090 1100
LDKFKARWDQ LKPGDDIIET GQQNTMDQSA KSIKEKKIEF DDLEVIRKKL
1110 1120 1130 1140 1150
VDDCHHFGLE EPNFSLAYSI SKDIESCAQI WALYEEFQQG LQDMAKEDWI
1160 1170 1180 1190 1200
TYRAKIYLFE EFLINWHERL RKIEEHSVMT VKLQSEVDRY KMIIPILKYV
1210 1220 1230 1240 1250
RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTI VEKASELKDL
1260 1270 1280 1290 1300
NSRAQGEVTI REALRELDLW GVGAVFSLID YEDSQNHTIK LIKDWKDIVN
1310 1320 1330 1340 1350
QVGDNRCLLQ SLKDSPYYKG FEDKVSIWER KLAQLDEYLQ NLNHIQRKWV
1360 1370 1380 1390 1400
YLEPIFGRGA LPKEQTRFNK VDEDFRSIMM DIRKDSRVTT LTTHAGIRNT
1410 1420 1430 1440 1450
LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI LGQSTNPSVI
1460 1470 1480 1490 1500
QSHLKKLFAG INSVCFDEES KHITAMKSLE GEVVPFKSKV LLSNNVEAWL
1510 1520 1530 1540 1550
NDLALEMKQT LKQLLKECVT AGRSSQGAID PSLFPSQILC LAEQIKFTED
1560 1570 1580 1590 1600
VENAIKDHSL HQIEAQLVAK LERYTSVDTS SEDPGNSESG ILELKLKALI
1610 1620 1630 1640 1650
LDIIHNIDIV KQLNQVQVHT TDDWAWKKQV RFYMKSDHTC YVQMVDSELQ
1660 1670 1680 1690 1700
YTYEYQGNAP KLVYTPLTDK CYLTLTQAMK MGLGGNPYGP AGTGKTESVK
1710 1720 1730 1740 1750
ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF DEFNRLEEAV
1760 1770 1780 1790 1800
LSAVSMQIQT IQDALKNHRT VCELLGKEVE INANSGIFIT MNPAGKGYGG
1810 1820 1830 1840 1850
RQKLPDNLKQ LFRPVAMSRP DNDLIAEVIL YSEGFKDAKE LGRKLVAIFN
1860 1870 1880 1890 1900
LSRELLTPQQ HYDWGLRALK TVLRGSGNLL RQLKKNSTKQ DVNENHIVVQ
1910 1920 1930 1940 1950
ALRLNTMSKF TFADCTRFDA LIKDVFPGID FKEVEYDELS SALKQVFEEA
1960 1970 1980 1990 2000
NYEVIPNQMK KALELYEQLR QRTGVVIVGP SGAGKSTLWR MLRAALCKIG
2010 2020 2030 2040 2050
KVVKQYTMNP KAMPRHQLLG HIDMDTREWS DGVLTNSARQ VVREPQDVSS
2060 2070 2080 2090 2100
WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPNV NFVFETHDLS
2110 2120 2130 2140 2150
CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPLEYRSN LENWIGDYFS
2160 2170 2180 2190 2200
KALQWVLKQN DYVVETSLVG TVMNGLSHLH GCKYHDQFII NLIRGLGGNL
2210 2220 2230 2240 2250
NMKSRLEFTK EVFNWARETP PDSHRPMDTY YDCDRGQLAS YMLKKPESLT
2260 2270 2280 2290 2300
ADDFSNGHIL PVIQTPDMQR GLDYFKPWLS SDTKQPFILV GPEGCGKGML
2310 2320 2330 2340 2350
LRYAFSQLRS TEIATIHCSA QTTSRHLLQK LSQTCMVIST NTGRVYRPKD
2360 2370 2380 2390 2400
CERLVLYLKD INLPKLDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI
2410 2420 2430 2440 2450
QIVASMSAGG RLGRHKLTTR FTSIVRLCAI DYPEREQLQT IYGAYLEAVL
2460 2470 2480 2490 2500
HKNLKNHSIW GSSSKIYLLA GSMVQVYEQV RAKFTVDEYS HYFFTPCILT
2510 2520 2530 2540 2550
QWVLGLFRYD LEGGSSNHPL DYVLEIVAYE ARRLFRDKIV GVKELHLFDN
2560 2570 2580 2590 2600
ILTSVLQGDW GSDILDNMAD SFYVTWGAHH VSGGKTAPGQ PLPPHGKPLG
2610 2620 2630 2640 2650
KLTSADLKDV IKKGLIHYGR DNQNLDILLF QEVLEYMSRI DRVLSFPGGS
2660 2670 2680 2690 2700
LLLAGRSGVG RRTVTSLVSH MHGAVLFSPK ISRGYEPKQF RNDLKHVLQL
2710 2720 2730 2740 2750
AGIEAQQVVL LLEDYQFVHP TFLEMINSLL ASGEVPGLYT LEELEPLLLP
2760 2770 2780 2790 2800
LKDQASQDGF FGPVFNYFTY RIQQNLHIVL IMDSANLNFI VNCESNPALH
2810 2820 2830 2840 2850
KKCQVLWMEG WSDSSMKKIP EMLFSETDGE EKYEKKRKDE KKRNSVDPDF
2860 2870 2880 2890 2900
IKSFLLIHES CKAYGATPSR YMTFLHVYSA ISSSKKKELL KRQSHLQAGV
2910 2920 2930 2940 2950
SKLNEAKALV DELNRKAGEQ SILLRIKQDE ADSALQEITV SMQDASEQKT
2960 2970 2980 2990 3000
ELERLKQRIA EEVVKIEERK SKIDDELKEV QPLVNEAKLA VGNIRPESLS
3010 3020 3030 3040 3050
EIRSLRMPPD VIRDILEGVL RLMGIFDTSW VSMKSFLAKR GVREDIATFD
3060 3070 3080 3090 3100
ARNIPKEIRE SVEELLFKNK ASFDPKNAKR ASTAAAPLAA WVKANVQYSH
3110 3120 3130 3140 3150
VLERIQPLET EQSGLELNLK KTEDRKRKLE DLLNSVGQKV SELKEKFQSR
3160 3170 3180 3190 3200
TSEAAKLEAE VSKAQETIKA AEVLISQLDR EHRRWNAQVA EIAEELATLP
3210 3220 3230 3240 3250
KRAQLAAAFI TYLSAAPEGL RKNCLEEWTK AAGLEKFDLR RFLCTESEQL
3260 3270 3280 3290 3300
IWKSEGLPSD DLSIENALVI LQSRVCPFLI DPSSQATEWL KTHLKDSHLE
3310 3320 3330 3340 3350
VINQQDSNFI TALELAVRFG KTLIIQEMDG VEPVLYPLLR RDLVAQGPRY
3360 3370 3380 3390 3400
VVQIGDKIID YNEDFRLFLS TRNPNPFIPP DAASIVTEVN FTTTRSGLRG
3410 3420 3430 3440 3450
QLLALTIQHE KPDLEEQKTK LLQQEEDKKI QLARLEESLL ETLATSQGNI
3460 3470 3480 3490 3500
LENKDLIESL NQTKASSALI QDSLKESYKL QISLDQERDA YLPLAESASK
3510 3520 3530 3540 3550
MYFIISDLSK INNMYRFSLA SFLRLFQRAL QNKQDSENTE ERIQCLVNSL
3560 3570 3580 3590 3600
KHMVYEYICR CLFKADQLMF ALHFVRGMHP ELFQENEWDT FTGVVVGDML
3610 3620 3630 3640 3650
RKADSQQRIR DQLPSWIDQE RSWAVATLKI SLPSLYQTLC LEDGAFWRTY
3660 3670 3680 3690 3700
YHHSMCEQEF PSILAKKVSL FQQVLVVQAL RPDRLQSAMA LFACKALGLK
3710 3720 3730 3740 3750
ELSPLPLNLK RLYKETLEIE PILIIISPGA DPSQELQELA SAERSSECYH
3760 3770 3780 3790 3800
QVAMGQGQAD LAIQMLKECA RNGDWLCLKN LHLVVSWLPV LEKELNTLQP
3810 3820 3830 3840 3850
KDSFRLWLTA EVHPNFTPIL LQSSLKITYE SPPGLKKNLM RTYESWTPEQ
3860 3870 3880 3890 3900
ISKRDNIHRA HALFSLAWFH AACQERRNYI PQGWTKFYEF SLSDLRAGYH
3910 3920 3930 3940 3950
VIDRLFDGTK DVQWEFVHGL LENSIYGGRV DNYFDLRVLQ SYLKQFFNSS
3960 3970 3980 3990 4000
IIDVLNQRNK KSIFPYSISL PNSCSILDYR AVIEKLPEDD KPSFFGLPAN
4010 4020 4030 4040 4050
IARSSQRMIS SQVISQLRIL GRSVTAGCKF DREIWSNELS PVLNLWKKLN
4060 4070 4080 4090 4100
QNSNLIHQKV SPPNDRQGSP ILSFIILEQF NAIRLVQSVH QSLAALSKVI
4110 4120 4130 4140 4150
RGTTLLSSEV QKLASALLNQ KCPLTWQSRW EGPEDPLQYL RGLVARTLAI
4160 4170 4180 4190 4200
QNWVEKAEKQ VLLADTLDLS ELFHPDTFLN ALRQETARAT GCSVDSLKFV
4210 4220 4230 4240 4250
ASWKGRLQEA KLQIKISGLL LEGCSFDGNR LSENQHDSPS VSSVLPCYMG
4260 4270 4280 4290 4300
WTPQGSYGPY SPDECISLPV YTSAERERVV TNIDVPCGGN QDQWIQCGAA

LFLKNQ
Length:4,306
Mass (Da):492,339
Last modified:September 13, 2005 - v1
Checksum:i0899EEC8224F4B04
GO
Isoform 2 (identifier: Q45VK7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3272-3272: Q → QIIGLKSW

Show »
Length:4,313
Mass (Da):493,137
Checksum:i19AFDB18AC9303CB
GO
Isoform 3 (identifier: Q45VK7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-335: L → P
     337-4306: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):38,857
Checksum:i1DFEDCF8F2CEE471
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z025D3Z025_MOUSE
Cytoplasmic dynein 2 heavy chain 1
Dync2h1
916Annotation score:
F6QLS2F6QLS2_MOUSE
Cytoplasmic dynein 2 heavy chain 1
Dync2h1
385Annotation score:
A0A1L1SS48A0A1L1SS48_MOUSE
Cytoplasmic dynein 2 heavy chain 1
Dync2h1
596Annotation score:
A0A1L1SRI6A0A1L1SRI6_MOUSE
Cytoplasmic dynein 2 heavy chain 1
Dync2h1
426Annotation score:

Sequence cautioni

The sequence BAB29399 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38914 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33L → F in BAC28057 (PubMed:16141072).Curated1
Sequence conflicti1254A → P in AAS15576 (Ref. 4) Curated1
Sequence conflicti1664Y → I in CAB06063 (PubMed:9373155).Curated1
Sequence conflicti1687P → G in CAB06063 (PubMed:9373155).Curated1
Sequence conflicti1773E → D in CAB06063 (PubMed:9373155).Curated1
Sequence conflicti1864W → Y in CAB06063 (PubMed:9373155).Curated1
Sequence conflicti1866 – 1867LR → IS in CAB06063 (PubMed:9373155).Curated2
Sequence conflicti2687P → R in AAS15578 (Ref. 4) Curated1
Sequence conflicti2699Q → K in BAC38914 (PubMed:16141072).Curated1
Sequence conflicti2734E → K in AAS15578 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031284335L → P in isoform 3. 1 Publication1
Alternative sequenceiVSP_031285337 – 4306Missing in isoform 3. 1 PublicationAdd BLAST3970
Alternative sequenceiVSP_0312863272Q → QIIGLKSW in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104402 mRNA Translation: AAZ41367.1
AK014500 mRNA Translation: BAB29399.2 Different initiation.
AK032860 mRNA Translation: BAC28057.1
AK045978 mRNA Translation: BAC32559.1
AK046538 mRNA Translation: BAC32776.1
AK083433 mRNA Translation: BAC38914.1 Different initiation.
AK084796 mRNA Translation: BAC39280.1
CT010499, AC155908 Genomic DNA Translation: CAX15687.1
CT010499, AC155908 Genomic DNA Translation: CAX15688.1
AY452064 mRNA Translation: AAS15576.1
AY452065 mRNA Translation: AAS15577.1
AY452066 mRNA Translation: AAS15578.1
AY452067 mRNA Translation: AAS15579.1
Z83809 mRNA Translation: CAB06063.1
AK173324 mRNA Translation: BAD32602.1
CCDSiCCDS40528.1 [Q45VK7-1]
RefSeqiNP_084127.2, NM_029851.2 [Q45VK7-1]
XP_006509889.1, XM_006509826.3 [Q45VK7-2]
UniGeneiMm.237596

Genome annotation databases

EnsembliENSMUST00000048417; ENSMUSP00000046733; ENSMUSG00000047193 [Q45VK7-1]
ENSMUST00000140466; ENSMUSP00000120007; ENSMUSG00000047193 [Q45VK7-1]
ENSMUST00000147193; ENSMUSP00000116679; ENSMUSG00000047193 [Q45VK7-2]
GeneIDi110350
KEGGimmu:110350
UCSCiuc009occ.1 mouse [Q45VK7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104402 mRNA Translation: AAZ41367.1
AK014500 mRNA Translation: BAB29399.2 Different initiation.
AK032860 mRNA Translation: BAC28057.1
AK045978 mRNA Translation: BAC32559.1
AK046538 mRNA Translation: BAC32776.1
AK083433 mRNA Translation: BAC38914.1 Different initiation.
AK084796 mRNA Translation: BAC39280.1
CT010499, AC155908 Genomic DNA Translation: CAX15687.1
CT010499, AC155908 Genomic DNA Translation: CAX15688.1
AY452064 mRNA Translation: AAS15576.1
AY452065 mRNA Translation: AAS15577.1
AY452066 mRNA Translation: AAS15578.1
AY452067 mRNA Translation: AAS15579.1
Z83809 mRNA Translation: CAB06063.1
AK173324 mRNA Translation: BAD32602.1
CCDSiCCDS40528.1 [Q45VK7-1]
RefSeqiNP_084127.2, NM_029851.2 [Q45VK7-1]
XP_006509889.1, XM_006509826.3 [Q45VK7-2]
UniGeneiMm.237596

3D structure databases

ProteinModelPortaliQ45VK7
SMRiQ45VK7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046733

PTM databases

iPTMnetiQ45VK7
PhosphoSitePlusiQ45VK7

Proteomic databases

PaxDbiQ45VK7
PRIDEiQ45VK7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048417; ENSMUSP00000046733; ENSMUSG00000047193 [Q45VK7-1]
ENSMUST00000140466; ENSMUSP00000120007; ENSMUSG00000047193 [Q45VK7-1]
ENSMUST00000147193; ENSMUSP00000116679; ENSMUSG00000047193 [Q45VK7-2]
GeneIDi110350
KEGGimmu:110350
UCSCiuc009occ.1 mouse [Q45VK7-1]

Organism-specific databases

CTDi79659
MGIiMGI:107736 Dync2h1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00760000118964
HOVERGENiHBG107832
InParanoidiQ45VK7
KOiK10414
OMAiANAHRAW
OrthoDBiEOG091G0313
TreeFamiTF315251

Enzyme and pathway databases

ReactomeiR-MMU-5610787 Hedgehog 'off' state
R-MMU-5620924 Intraflagellar transport

Miscellaneous databases

PROiPR:Q45VK7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047193 Expressed in 209 organ(s), highest expression level in testis
CleanExiMM_DYNC2H1
ExpressionAtlasiQ45VK7 baseline and differential
GenevisibleiQ45VK7 MM

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR011704 ATPase_dyneun-rel_AAA
IPR035706 DHC_D5
IPR026983 DHC_fam
IPR026815 DYNC2H1
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_dom
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PTHR10676:SF352 PTHR10676:SF352, 1 hit
PfamiView protein in Pfam
PF07728 AAA_5, 1 hit
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 3 hits
SUPFAMiSSF52540 SSF52540, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDYHC2_MOUSE
AccessioniPrimary (citable) accession number: Q45VK7
Secondary accession number(s): B8JJF9
, B8JJG0, O08822, Q5VI59, Q5VI60, Q5VI61, Q5VI62, Q69Z42, Q8BJL5, Q8BL87, Q8BMC7, Q8BUI9, Q8BXK5, Q9CRR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 13, 2005
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again