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Entry version 99 (10 Feb 2021)
Sequence version 1 (13 Sep 2005)
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Protein
Submitted name:

Nuclear factor 90

Gene

Ilf3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation, RNA-bindingPROSITE-ProRule annotationARBA annotation
Biological processAntiviral defenseARBA annotation, Transcription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear factor 90Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ilf3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1339973, Ilf3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q45VK6

PRoteomics IDEntifications database

More...
PRIDEi
Q45VK6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q45VK6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q45VK6, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q45VK6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 391DZFInterPro annotationAdd BLAST374
Domaini411 – 480DRBMInterPro annotationAdd BLAST70
Domaini537 – 603DRBMInterPro annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 98DisorderedSequence analysisAdd BLAST33
Regioni376 – 415DisorderedSequence analysisAdd BLAST40
Regioni479 – 508DisorderedSequence analysisAdd BLAST30
Regioni518 – 537DisorderedSequence analysisAdd BLAST20
Regioni649 – 674DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi80 – 98PolyampholyteSequence analysisAdd BLAST19
Compositional biasi385 – 412PolyampholyteSequence analysisAdd BLAST28
Compositional biasi518 – 534PolarSequence analysisAdd BLAST17

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
612611at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048, DSRM, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.460.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014720, dsRBD_dom
IPR006561, DZF_dom
IPR033099, ILF3/NF90
IPR043519, NT_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45762:SF4, PTHR45762:SF4, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00035, dsrm, 2 hits
PF07528, DZF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00358, DSRM, 2 hits
SM00572, DZF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50137, DS_RBD, 2 hits
PS51703, DZF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q45VK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALYHHHFIT RRRRRPMRIF VNDDRHVMAK HSSVYPTQEE LEAVQNMVSH
60 70 80 90 100
TERALKAVSD WIDEQEKGNS ELSEAENMDT PPDDESKEGA GEQKAEHMTR
110 120 130 140 150
TLRGVMRVGL VAKGLLLKGD LDLELVLLCK EKPTTALLDK VADNLAIQLT
160 170 180 190 200
TVTEDKYEIL QSVDDAAIVI KNTKEPPLSL TIHLTSPVVR EEMEKVLAGE
210 220 230 240 250
TLSVNDPPDV LDRQKCLAAL ASLRHAKWFQ ARANGLKSCV IVIRVLRDLC
260 270 280 290 300
TRVPTWGPLR GWPLELLCEK SIGTANRPMG AGEALRRVLE CLASGIVMPD
310 320 330 340 350
GSGIYDPCEK EATDAIGHLD RQQREDITQS AQHALRLAAF GQLHKVLGMD
360 370 380 390 400
PLPSKMPKKP KNENPVDYTV QIPPSTTYAI TPMKRPMEED GEEKSPSKKK
410 420 430 440 450
KKIQKKEEKA DPPQAMNALM RLNQLKPGLQ YKLISQTGPV HAPIFTMSVE
460 470 480 490 500
VDGSNFEASG PSKKTAKLHV AVKVLQDMGL PTGAEGRDSS KGEDSAEESD
510 520 530 540 550
GKPAIVAPPP VVEAVSNPSS VFPSDATTEQ GPILTKHGKN PVMELNEKRR
560 570 580 590 600
GLKYELISET GGSHDKRFVM EVEVDGQKFQ GAGSNKKVAK AYAALAALEK
610 620 630 640 650
LFPDTPLALE ANKKKRTPVP VRGGPKFAAK PHNPGFGMGG PMHNEVPPPP
660 670 680 690 700
NIRGRGRGGN IRGRGRGRGF GGANHGGGYM NAGAGYGSYG YSSNSATAGY
710
SDFFTDCYGY HDFGAS
Length:716
Mass (Da):78,093
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31524B0E69250CCB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ104405 mRNA Translation: AAZ20651.1

NCBI Reference Sequences

More...
RefSeqi
NP_001036173.1, NM_001042708.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16201

UCSC genome browser

More...
UCSCi
uc009olb.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104405 mRNA Translation: AAZ20651.1
RefSeqiNP_001036173.1, NM_001042708.2

3D structure databases

SMRiQ45VK6
ModBaseiSearch...

Proteomic databases

PeptideAtlasiQ45VK6
PRIDEiQ45VK6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1051, 330 antibodies

Genome annotation databases

GeneIDi16201
UCSCiuc009olb.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3609
MGIiMGI:1339973, Ilf3

Phylogenomic databases

OrthoDBi612611at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
16201, 6 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ilf3, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

ExpressionAtlasiQ45VK6, baseline and differential
GenevisibleiQ45VK6, MM

Family and domain databases

CDDicd00048, DSRM, 2 hits
Gene3Di3.30.460.10, 1 hit
InterProiView protein in InterPro
IPR014720, dsRBD_dom
IPR006561, DZF_dom
IPR033099, ILF3/NF90
IPR043519, NT_sf
PANTHERiPTHR45762:SF4, PTHR45762:SF4, 3 hits
PfamiView protein in Pfam
PF00035, dsrm, 2 hits
PF07528, DZF, 1 hit
SMARTiView protein in SMART
SM00358, DSRM, 2 hits
SM00572, DZF, 1 hit
PROSITEiView protein in PROSITE
PS50137, DS_RBD, 2 hits
PS51703, DZF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ45VK6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q45VK6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: February 10, 2021
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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