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UniProtKB - Q45VK6 (Q45VK6_MOUSE)

Entry version 99 (10 Feb 2021)
Sequence version 1 (13 Sep 2005)
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Protein
Submitted name:

Nuclear factor 90

Gene

Ilf3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation, RNA-bindingPROSITE-ProRule annotationARBA annotation
Biological processAntiviral defenseARBA annotation, Transcription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear factor 90Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ilf3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1339973, Ilf3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		Q45VK6

PRoteomics IDEntifications database

More...PRIDEi		Q45VK6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q45VK6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q45VK6, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q45VK6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 391DZFInterPro annotationAdd BLAST374
Domaini411 – 480DRBMInterPro annotationAdd BLAST70
Domaini537 – 603DRBMInterPro annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 98DisorderedSequence analysisAdd BLAST33
Regioni376 – 415DisorderedSequence analysisAdd BLAST40
Regioni479 – 508DisorderedSequence analysisAdd BLAST30
Regioni518 – 537DisorderedSequence analysisAdd BLAST20
Regioni649 – 674DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi80 – 98PolyampholyteSequence analysisAdd BLAST19
Compositional biasi385 – 412PolyampholyteSequence analysisAdd BLAST28
Compositional biasi518 – 534PolarSequence analysisAdd BLAST17

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		612611at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00048, DSRM, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.460.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014720, dsRBD_dom
IPR006561, DZF_dom
IPR033099, ILF3/NF90
IPR043519, NT_sf

The PANTHER Classification System

More...PANTHERi		PTHR45762:SF4, PTHR45762:SF4, 3 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00035, dsrm, 2 hits
PF07528, DZF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00358, DSRM, 2 hits
SM00572, DZF, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50137, DS_RBD, 2 hits
PS51703, DZF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q45VK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALYHHHFIT RRRRRPMRIF VNDDRHVMAK HSSVYPTQEE LEAVQNMVSH 
        60         70         80         90        100
TERALKAVSD WIDEQEKGNS ELSEAENMDT PPDDESKEGA GEQKAEHMTR 
       110        120        130        140        150
TLRGVMRVGL VAKGLLLKGD LDLELVLLCK EKPTTALLDK VADNLAIQLT 
       160        170        180        190        200
TVTEDKYEIL QSVDDAAIVI KNTKEPPLSL TIHLTSPVVR EEMEKVLAGE 
       210        220        230        240        250
TLSVNDPPDV LDRQKCLAAL ASLRHAKWFQ ARANGLKSCV IVIRVLRDLC 
       260        270        280        290        300
TRVPTWGPLR GWPLELLCEK SIGTANRPMG AGEALRRVLE CLASGIVMPD 
       310        320        330        340        350
GSGIYDPCEK EATDAIGHLD RQQREDITQS AQHALRLAAF GQLHKVLGMD 
       360        370        380        390        400
PLPSKMPKKP KNENPVDYTV QIPPSTTYAI TPMKRPMEED GEEKSPSKKK 
       410        420        430        440        450
KKIQKKEEKA DPPQAMNALM RLNQLKPGLQ YKLISQTGPV HAPIFTMSVE 
       460        470        480        490        500
VDGSNFEASG PSKKTAKLHV AVKVLQDMGL PTGAEGRDSS KGEDSAEESD 
       510        520        530        540        550
GKPAIVAPPP VVEAVSNPSS VFPSDATTEQ GPILTKHGKN PVMELNEKRR 
       560        570        580        590        600
GLKYELISET GGSHDKRFVM EVEVDGQKFQ GAGSNKKVAK AYAALAALEK 
       610        620        630        640        650
LFPDTPLALE ANKKKRTPVP VRGGPKFAAK PHNPGFGMGG PMHNEVPPPP 
       660        670        680        690        700
NIRGRGRGGN IRGRGRGRGF GGANHGGGYM NAGAGYGSYG YSSNSATAGY 
       710 
SDFFTDCYGY HDFGAS
Length:716
Mass (Da):78,093
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31524B0E69250CCB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ104405 mRNA Translation: AAZ20651.1

NCBI Reference Sequences

More...RefSeqi		NP_001036173.1, NM_001042708.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		16201

UCSC genome browser

More...UCSCi		uc009olb.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104405 mRNA Translation: AAZ20651.1
RefSeqiNP_001036173.1, NM_001042708.2

3D structure databases

SMRiQ45VK6
ModBaseiSearch...

Proteomic databases

PeptideAtlasiQ45VK6
PRIDEiQ45VK6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1051, 330 antibodies

Genome annotation databases

GeneIDi16201
UCSCiuc009olb.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3609
MGIiMGI:1339973, Ilf3

Phylogenomic databases

OrthoDBi612611at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		16201, 6 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ilf3, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

ExpressionAtlasiQ45VK6, baseline and differential
GenevisibleiQ45VK6, MM

Family and domain databases

CDDicd00048, DSRM, 2 hits
Gene3Di3.30.460.10, 1 hit
InterProiView protein in InterPro
IPR014720, dsRBD_dom
IPR006561, DZF_dom
IPR033099, ILF3/NF90
IPR043519, NT_sf
PANTHERiPTHR45762:SF4, PTHR45762:SF4, 3 hits
PfamiView protein in Pfam
PF00035, dsrm, 2 hits
PF07528, DZF, 1 hit
SMARTiView protein in SMART
SM00358, DSRM, 2 hits
SM00572, DZF, 1 hit
PROSITEiView protein in PROSITE
PS50137, DS_RBD, 2 hits
PS51703, DZF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ45VK6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q45VK6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: February 10, 2021
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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