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Protein

Phosphoglycerate kinase

Gene
N/A
Organism
Fasciola hepatica (Liver fluke)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (D915_13480)
  2. Phosphoglycerate kinase (D915_03905), Phosphoglycerate kinase, Phosphoglycerate kinase, Phosphoglycerate kinase (D915_03906)
  3. no protein annotated in this organism
  4. Enolase (ENO)
  5. Pyruvate kinase (D915_13877), Pyruvate kinase (D915_02241)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38SubstrateUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Binding sitei218ATPUniRule annotation1
Binding sitei311ATP; via carbonyl oxygenUniRule annotation1
Binding sitei342ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi371 – 374ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKiQ45UT3
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
OrganismiFasciola hepatica (Liver fluke)Imported
Taxonomic identifieri6192 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaPlagiorchiidaEchinostomataEchinostomatoideaFasciolidaeFasciola

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ45UT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 25Substrate bindingUniRule annotation3
Regioni62 – 65Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 4 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q45UT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKKLSIAN VDLKGKRVLI RVDFNVPMKD GKITNNQRIV AALPTIKYAL
60 70 80 90 100
EKGAKSVVLM SHLGRPDGNK VDKYSLKPVA EEVSKLLGKA VQFLPDCVGD
110 120 130 140 150
ATLQACSNPA PGSVFLLENL RFHVEEEGKG VGPNGEKVKA DPAKVKAFSE
160 170 180 190 200
SLTKLGDVYV NDAFGTAHRA HASMVGCNLP QKACGFLMDK ELTYFAKALE
210 220 230 240 250
NPARPFLAII GGAKVSDKIQ LIKNMLDKVN ELIITGGMAF TFLKKLHNMK
260 270 280 290 300
IGKSLFDEPG AAIVDEVMAL AKQKKVEIHL PVDFVTGSKF GDDATVGSAT
310 320 330 340 350
VESGIPDDYM GLDCGPKTME KFRAVILRAK TIVWNGPMGV FEMEKFAGGT
360 370 380 390 400
KAAMDAVVEA TKNGATTIIG GGDTATCCAK WKTEDKVSHV STGGGASLEL
410 420 430
LEGKELPGVV ALLTPECLDR PFPRGLPRML RYFSFRR
Length:437
Mass (Da):47,000
Last modified:June 26, 2007 - v2
Checksum:i617C2402524D3EDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ112667 mRNA Translation: AAZ17561.2

Similar proteinsi

Entry informationi

Entry nameiQ45UT3_FASHE
AccessioniPrimary (citable) accession number: Q45UT3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: June 26, 2007
Last modified: February 28, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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