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UniProtKB - Q45R84 (Q45R84_STRFR)

Entry version 75 (19 Jan 2022)
Sequence version 1 (13 Sep 2005)
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Protein
Submitted name:

Peptide synthetase

Gene

lptB

Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Peptide synthetaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lptBImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces fradiae (Streptomyces roseoflavus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1906 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1007O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2087O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini972 – 1047CarrierInterPro annotationAdd BLAST76
Domaini2052 – 2127CarrierInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni566 – 586DisorderedSequence analysisAdd BLAST21
Regioni952 – 973DisorderedSequence analysisAdd BLAST22
Regioni1251 – 1274DisorderedSequence analysisAdd BLAST24
Regioni2032 – 2057DisorderedSequence analysisAdd BLAST26

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 1 hit
3.30.300.30, 2 hits
3.30.559.10, 2 hits
3.40.50.12780, 1 hit
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 2 hits
PF00550, PP-binding, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00823, PKS_PP, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336, SSF47336, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01733, AA-adenyl-dom, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 2 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q45R84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGPQRMVEE VLAVTPLQEG LLFHAVFDEN VPDAYVSRLV LALSGELDAD 
        60         70         80         90        100
RLRQAAQALV ARHPALRSAF RQRRSGEWFQ LVATRPAVPW QELDLRPSGS 
       110        120        130        140        150
PAEADKHLEA LLDEHHRTGF DLGRPPLLRF LLARTGDDHH RLAVTYHHLV 
       160        170        180        190        200
LDGWSMPILM RELAVLYGSG GDPSALPPVR PHRDHLDWLA RRPSERSARA 
       210        220        230        240        250
WRQALAGLPG PTLIAPDADR NGPLPGSVWT RLGERDTHAL GAWARARGVT 
       260        270        280        290        300
VNSAVQAAWA TVIGRLTGRD DVVFGTTVSG RPPDLPGSED MVGFFINTVP 
       310        320        330        340        350
TRVRMRPAEP IGDLVVRIQR EQTALMEHQH VRLSDIQRWS DRTVLFDTST 
       360        370        380        390        400
AFENYPADDL SAVSSAGHAG LRIEGGSGRT TNHFPLSLYA LPGPALRLRL 
       410        420        430        440        450
DHRPDAVDDV TTRHAADLLE RALTAVHSAP ATPTAALAAT PATARAAAPR 
       460        470        480        490        500
AAGPGAPATI VDAFEARVRA TPEAPAVLAG GEELTYAELD ARANRLARLL 
       510        520        530        540        550
LERGVGPESR VALTVSRNAW LPVAVLGILK AGGCYVPVGA TLPRERAARI 
       560        570        580        590        600
LRETAPVCLL TDPDAEAART RRTAPTGDDR DENAPGGVER VVLTGALLAA 
       610        620        630        640        650
FDPAPPTDAE RAGPLLPGHL AYLLHTSGSS GRPKGVAVEH AQVTALLSWA 
       660        670        680        690        700
GTGVGADRLH RTVASTSESF DVSVFDTLVP LLTGGRIEIV ENTLAVADRT 
       710        720        730        740        750
GGEPSLLNAV PSALQALLER GEPLAVHTFL CAGEPFPAPL ARSLRAAFPR 
       760        770        780        790        800
ARVANLYGPT ETTVFVTAHF LDGTDDGAPP VGRPLPGVRV HILDPWLRPV 
       810        820        830        840        850
PDGVVGELYL AGEHVTRGYW QRPATTAERY VADIFGAPGA RMYRSGDLGR 
       860        870        880        890        900
LRPDGEIDLV GRADDQVKVR GHRVELGEVE AALASHPDVL RAAAAVHDGK 
       910        920        930        940        950
PAGPRLVGYV VPRGPAPDTA AVLDHVRREV PPYMVPSALV VLDELPLTVN 
       960        970        980        990       1000
GKRDRAALPP PPDRSDTTRA RAPRGPHETI LLGLFAEVLG VRPVGIDDDF 
      1010       1020       1030       1040       1050
FALGGHSLLA TRLVSRVRTT LGAELAVRDL FEHPTVAGLY ARIARAGAAR 
      1060       1070       1080       1090       1100
PPVSRVHARP DRVPLSFAQR RLWFLHRLQG HSAAYHVPLA LRLTGRLDPA 
      1110       1120       1130       1140       1150
ALRGAIADTV ARHGSLRTVF HEDAEGVRQI VQDASAAARL ITLIPEPVED 
      1160       1170       1180       1190       1200
PLRAAEEAVA EPFDLTAGPP LRCRLFTRSA DPADPRAGAG QEPQEHLFLL 
      1210       1220       1230       1240       1250
VVHHIAADGW SLRIIARDVA AAYAARVRGE DFAPAPPPVD YVDHTLWQHR 
      1260       1270       1280       1290       1300
VLGDPDADGG PDTEGGHATE GGPLDTQLAH WRRRLAGLPQ EIALPADRQR 
      1310       1320       1330       1340       1350
PAASSHRGAD VDFTVPAAAA ERIRQLAGTT GTTPFMVLQA ALAVLLHRMG 
      1360       1370       1380       1390       1400
AGTDIPLGTP VAGRTDSAVE GVVGLFVNTL VLRTDLSGSP TFAQLLGRVR 
      1410       1420       1430       1440       1450
ATALDAYAHQ DVPFERLVEV LAPERSLARH PLFQVSLVLQ NLDEAAAPVD 
      1460       1470       1480       1490       1500
GLPGLRAETV RTRRDGAKVD LSFVLAPGGP EGGDMPGVLT YSADLFDHAT 
      1510       1520       1530       1540       1550
ARGLVDRLLR VLDQVLAAPA TPVGRVDVLL PGEARRELEH SRGPGAAGDG 
      1560       1570       1580       1590       1600
DEPLARFEKW AATTPDAPAL RWDGGRLTYA ELDRKADAVA RALVGRSLGP 
      1610       1620       1630       1640       1650
EDVVAVVAPR DPDVVAALLG VLRCGAAYLP IDEAWPPARI RRTTTDAGAR 
      1660       1670       1680       1690       1700
LLLAPGDTDA ARTAFGPACG PDTDILGLED PAFRATGGPA LPAGRNHPRS 
      1710       1720       1730       1740       1750
LAYVLYTSGS TGRPKGVGVE RRALAHYVEG AVHRYPDAAA TTLLHSPLTF 
      1760       1770       1780       1790       1800
DLSATALFTP LASGGCVVLG EVDRAAEAHP VDFVKATPSH LPLLERRPGL 
      1810       1820       1830       1840       1850
LGENGTLVLG GEALDGRALR AWRAAHPHAE VVNAYGPTEL TVNCAEHRIA 
      1860       1870       1880       1890       1900
AGEPVPDGPV PIGRPFAGVR AMVLDTALAP APPGVAGELY VTGPGVARGY 
      1910       1920       1930       1940       1950
LGQRALTAER FVACPFGEPG ERMYRTGDLV RRLPGGELEY VGRTDEQVKL 
      1960       1970       1980       1990       2000
RGFRIELPEV ARTLAADESV ARAVVVVRED RPGDRRLTGY VVPAAGVRPH 
      2010       2020       2030       2040       2050
EDELRGAVAR TLPDYMVPSA VVVLDELPTT PHGKLDRRAL PAPAHRSRGG 
      2060       2070       2080       2090       2100
RPPRDQRERD LCRIYADVLG LPEVGAEDDF FALGGHSLLA TRLVNRIRAE 
      2110       2120       2130       2140 
LAEELDVRTV FEARTVAALA ARLRTARPDT RPALRRMSRS EDL
Length:2,143
Mass (Da):228,993
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9E57E6BC6588651
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ118863 Genomic DNA Translation: AAZ23076.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ118863 Genomic DNA Translation: AAZ23076.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.30.300.30, 2 hits
3.30.559.10, 2 hits
3.40.50.12780, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 2 hits
PF00550, PP-binding, 2 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 2 hits
SUPFAMiSSF47336, SSF47336, 2 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 2 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 2 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ45R84_STRFR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q45R84
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: January 19, 2022
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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