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UniProtKB - Q45R84 (Q45R84_STRFR)
Protein
Submitted name:
Peptide synthetase
Gene
lptB
Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Functioni
Cofactori
pantetheine 4'-phosphateARBA annotation
GO - Molecular functioni
- catalytic activity Source: UniProtKB-KW
- phosphopantetheine binding Source: InterPro
GO - Biological processi
- amide biosynthetic process Source: UniProt
- antibiotic biosynthetic process Source: UniProt
- lipid biosynthetic process Source: UniProt
- organic cyclic compound biosynthetic process Source: UniProt
- organonitrogen compound biosynthetic process Source: UniProt
- polyketide biosynthetic process Source: UniProt
Names & Taxonomyi
Protein namesi | Submitted name: Peptide synthetaseImported |
Gene namesi | Name:lptBImported |
Organismi | Streptomyces fradiae (Streptomyces roseoflavus)Imported |
Taxonomic identifieri | 1906 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1007 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 | |
Modified residuei | 2087 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 972 – 1047 | CarrierInterPro annotationAdd BLAST | 76 | |
Domaini | 2052 – 2127 | CarrierInterPro annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 566 – 586 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 952 – 973 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1251 – 1274 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 2032 – 2057 | DisorderedSequence analysisAdd BLAST | 26 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.30.300.30, 2 hits 3.30.559.10, 2 hits 3.40.50.12780, 1 hit 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR010071, AA_adenyl_domain IPR029058, AB_hydrolase IPR036736, ACP-like_sf IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR020806, PKS_PP-bd IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site |
Pfami | View protein in Pfam PF00501, AMP-binding, 2 hits PF13193, AMP-binding_C, 2 hits PF00668, Condensation, 2 hits PF00550, PP-binding, 2 hits |
SMARTi | View protein in SMART SM00823, PKS_PP, 2 hits |
SUPFAMi | SSF47336, SSF47336, 2 hits |
TIGRFAMsi | TIGR01733, AA-adenyl-dom, 2 hits |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 2 hits PS50075, CARRIER, 2 hits PS00012, PHOSPHOPANTETHEINE, 2 hits |
i Sequence
Sequence statusi: Complete.
Q45R84-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGPQRMVEE VLAVTPLQEG LLFHAVFDEN VPDAYVSRLV LALSGELDAD
60 70 80 90 100
RLRQAAQALV ARHPALRSAF RQRRSGEWFQ LVATRPAVPW QELDLRPSGS
110 120 130 140 150
PAEADKHLEA LLDEHHRTGF DLGRPPLLRF LLARTGDDHH RLAVTYHHLV
160 170 180 190 200
LDGWSMPILM RELAVLYGSG GDPSALPPVR PHRDHLDWLA RRPSERSARA
210 220 230 240 250
WRQALAGLPG PTLIAPDADR NGPLPGSVWT RLGERDTHAL GAWARARGVT
260 270 280 290 300
VNSAVQAAWA TVIGRLTGRD DVVFGTTVSG RPPDLPGSED MVGFFINTVP
310 320 330 340 350
TRVRMRPAEP IGDLVVRIQR EQTALMEHQH VRLSDIQRWS DRTVLFDTST
360 370 380 390 400
AFENYPADDL SAVSSAGHAG LRIEGGSGRT TNHFPLSLYA LPGPALRLRL
410 420 430 440 450
DHRPDAVDDV TTRHAADLLE RALTAVHSAP ATPTAALAAT PATARAAAPR
460 470 480 490 500
AAGPGAPATI VDAFEARVRA TPEAPAVLAG GEELTYAELD ARANRLARLL
510 520 530 540 550
LERGVGPESR VALTVSRNAW LPVAVLGILK AGGCYVPVGA TLPRERAARI
560 570 580 590 600
LRETAPVCLL TDPDAEAART RRTAPTGDDR DENAPGGVER VVLTGALLAA
610 620 630 640 650
FDPAPPTDAE RAGPLLPGHL AYLLHTSGSS GRPKGVAVEH AQVTALLSWA
660 670 680 690 700
GTGVGADRLH RTVASTSESF DVSVFDTLVP LLTGGRIEIV ENTLAVADRT
710 720 730 740 750
GGEPSLLNAV PSALQALLER GEPLAVHTFL CAGEPFPAPL ARSLRAAFPR
760 770 780 790 800
ARVANLYGPT ETTVFVTAHF LDGTDDGAPP VGRPLPGVRV HILDPWLRPV
810 820 830 840 850
PDGVVGELYL AGEHVTRGYW QRPATTAERY VADIFGAPGA RMYRSGDLGR
860 870 880 890 900
LRPDGEIDLV GRADDQVKVR GHRVELGEVE AALASHPDVL RAAAAVHDGK
910 920 930 940 950
PAGPRLVGYV VPRGPAPDTA AVLDHVRREV PPYMVPSALV VLDELPLTVN
960 970 980 990 1000
GKRDRAALPP PPDRSDTTRA RAPRGPHETI LLGLFAEVLG VRPVGIDDDF
1010 1020 1030 1040 1050
FALGGHSLLA TRLVSRVRTT LGAELAVRDL FEHPTVAGLY ARIARAGAAR
1060 1070 1080 1090 1100
PPVSRVHARP DRVPLSFAQR RLWFLHRLQG HSAAYHVPLA LRLTGRLDPA
1110 1120 1130 1140 1150
ALRGAIADTV ARHGSLRTVF HEDAEGVRQI VQDASAAARL ITLIPEPVED
1160 1170 1180 1190 1200
PLRAAEEAVA EPFDLTAGPP LRCRLFTRSA DPADPRAGAG QEPQEHLFLL
1210 1220 1230 1240 1250
VVHHIAADGW SLRIIARDVA AAYAARVRGE DFAPAPPPVD YVDHTLWQHR
1260 1270 1280 1290 1300
VLGDPDADGG PDTEGGHATE GGPLDTQLAH WRRRLAGLPQ EIALPADRQR
1310 1320 1330 1340 1350
PAASSHRGAD VDFTVPAAAA ERIRQLAGTT GTTPFMVLQA ALAVLLHRMG
1360 1370 1380 1390 1400
AGTDIPLGTP VAGRTDSAVE GVVGLFVNTL VLRTDLSGSP TFAQLLGRVR
1410 1420 1430 1440 1450
ATALDAYAHQ DVPFERLVEV LAPERSLARH PLFQVSLVLQ NLDEAAAPVD
1460 1470 1480 1490 1500
GLPGLRAETV RTRRDGAKVD LSFVLAPGGP EGGDMPGVLT YSADLFDHAT
1510 1520 1530 1540 1550
ARGLVDRLLR VLDQVLAAPA TPVGRVDVLL PGEARRELEH SRGPGAAGDG
1560 1570 1580 1590 1600
DEPLARFEKW AATTPDAPAL RWDGGRLTYA ELDRKADAVA RALVGRSLGP
1610 1620 1630 1640 1650
EDVVAVVAPR DPDVVAALLG VLRCGAAYLP IDEAWPPARI RRTTTDAGAR
1660 1670 1680 1690 1700
LLLAPGDTDA ARTAFGPACG PDTDILGLED PAFRATGGPA LPAGRNHPRS
1710 1720 1730 1740 1750
LAYVLYTSGS TGRPKGVGVE RRALAHYVEG AVHRYPDAAA TTLLHSPLTF
1760 1770 1780 1790 1800
DLSATALFTP LASGGCVVLG EVDRAAEAHP VDFVKATPSH LPLLERRPGL
1810 1820 1830 1840 1850
LGENGTLVLG GEALDGRALR AWRAAHPHAE VVNAYGPTEL TVNCAEHRIA
1860 1870 1880 1890 1900
AGEPVPDGPV PIGRPFAGVR AMVLDTALAP APPGVAGELY VTGPGVARGY
1910 1920 1930 1940 1950
LGQRALTAER FVACPFGEPG ERMYRTGDLV RRLPGGELEY VGRTDEQVKL
1960 1970 1980 1990 2000
RGFRIELPEV ARTLAADESV ARAVVVVRED RPGDRRLTGY VVPAAGVRPH
2010 2020 2030 2040 2050
EDELRGAVAR TLPDYMVPSA VVVLDELPTT PHGKLDRRAL PAPAHRSRGG
2060 2070 2080 2090 2100
RPPRDQRERD LCRIYADVLG LPEVGAEDDF FALGGHSLLA TRLVNRIRAE
2110 2120 2130 2140
LAEELDVRTV FEARTVAALA ARLRTARPDT RPALRRMSRS EDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ118863 Genomic DNA Translation: AAZ23076.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ118863 Genomic DNA Translation: AAZ23076.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.30.300.30, 2 hits 3.30.559.10, 2 hits 3.40.50.12780, 1 hit 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR010071, AA_adenyl_domain IPR029058, AB_hydrolase IPR036736, ACP-like_sf IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR020806, PKS_PP-bd IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site |
Pfami | View protein in Pfam PF00501, AMP-binding, 2 hits PF13193, AMP-binding_C, 2 hits PF00668, Condensation, 2 hits PF00550, PP-binding, 2 hits |
SMARTi | View protein in SMART SM00823, PKS_PP, 2 hits |
SUPFAMi | SSF47336, SSF47336, 2 hits |
TIGRFAMsi | TIGR01733, AA-adenyl-dom, 2 hits |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 2 hits PS50075, CARRIER, 2 hits PS00012, PHOSPHOPANTETHEINE, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q45R84_STRFR | |
Accessioni | Q45R84Primary (citable) accession number: Q45R84 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 13, 2005 |
Last sequence update: | September 13, 2005 | |
Last modified: | January 19, 2022 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |