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UniProtKB - Q45R83 (Q45R83_STRFR)
Protein
Submitted name:
Peptide synthetase
Gene
lptC
Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Functioni
Cofactori
pantetheine 4'-phosphateARBA annotation
GO - Molecular functioni
- catalytic activity Source: InterPro
- phosphopantetheine binding Source: InterPro
GO - Biological processi
- antibiotic biosynthetic process Source: UniProt
- lipid biosynthetic process Source: UniProt
- organic cyclic compound biosynthetic process Source: UniProt
- polyketide biosynthetic process Source: UniProt
Names & Taxonomyi
Protein namesi | Submitted name: Peptide synthetaseImported |
Gene namesi | Name:lptCImported |
Organismi | Streptomyces fradiae (Streptomyces roseoflavus)Imported |
Taxonomic identifieri | 1906 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1032 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 | |
Modified residuei | 2568 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 | |
Modified residuei | 3648 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 | |
Modified residuei | 4713 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 997 – 1071 | CarrierInterPro annotationAdd BLAST | 75 | |
Domaini | 2533 – 2608 | CarrierInterPro annotationAdd BLAST | 76 | |
Domaini | 3613 – 3688 | CarrierInterPro annotationAdd BLAST | 76 | |
Domaini | 4678 – 4752 | CarrierInterPro annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2513 – 2535 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 2825 – 2845 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 3910 – 3930 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 4658 – 4679 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 4743 – 4765 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 5210 – 5230 | DisorderedSequence analysisAdd BLAST | 21 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1879 – 1899 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 5213 – 5227 | Pro residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysisFamily and domain databases
Gene3Di | 1.10.1200.10, 4 hits 3.30.300.30, 4 hits 3.30.559.10, 6 hits |
InterProi | View protein in InterPro IPR010071, AA_adenyl_domain IPR036736, ACP-like_sf IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR010060, NRPS_synth IPR020806, PKS_PP-bd IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site |
Pfami | View protein in Pfam PF00501, AMP-binding, 4 hits PF13193, AMP-binding_C, 4 hits PF00668, Condensation, 6 hits PF00550, PP-binding, 4 hits |
SMARTi | View protein in SMART SM00823, PKS_PP, 4 hits |
SUPFAMi | SSF47336, SSF47336, 4 hits |
TIGRFAMsi | TIGR01733, AA-adenyl-dom, 4 hits TIGR01720, NRPS-para261, 2 hits |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 2 hits PS50075, CARRIER, 4 hits PS00012, PHOSPHOPANTETHEINE, 2 hits |
i Sequence
Sequence statusi: Complete.
Q45R83-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMLPLSLAQQ RLWFLHTMDG PSSTYNIPTA LRMTGPLDVT ALGEALRDVV
60 70 80 90 100
RRHETLRTVF PDTGDGARQH VLPADGTAVE LAVTRSTEHE LPAALAHEAG
110 120 130 140 150
HAFDLAREVP IRARLFVLGE REHVLCLVIH HIASDGWSRT PLARDLATAY
160 170 180 190 200
AARGAGHAPR WEELPVQYGD YTLWQRELLG SQDDPESLLS RQTAYWKQRL
210 220 230 240 250
AGLPDAIELP LDRPRPPIAG HRGDTVPFTL PPATHERVAA LAARHGATTF
260 270 280 290 300
MVVQAALAGL LSRLGAGTDI PLGTPVAGRT DAALEGLIGF FVNTLVLRTD
310 320 330 340 350
TSGNPTFDEL VERARACALD AYAHQDVPFE RLVETLAPER SLARHPLFQV
360 370 380 390 400
SLSLQHATDH TALLNGLEIA PLDTGWRAAK FDLSFDLLEK RGPDGRPDGI
410 420 430 440 450
AGTVEYSTDV LDAATVRGLG ERLVRLLEAG TAAPEARLLS IDLLSAEERR
460 470 480 490 500
RVLEEFAAEP AADEPAAAEP AADEGLEAVC DTFARQAAAT PEAPAVVGGP
510 520 530 540 550
VALTFAEADA RVSRLARLLI SRGAGPEVRV AVCLDRNALW PTTVLAVLRS
560 570 580 590 600
GAVHVPLDPR SPHERLAAVE RDVAPLLVLA ERATEAAVAD LAAPVLVLDD
610 620 630 640 650
PSTEAAIDAL DPGPVTDADR TAPLLPGHAA YVIHTSGSTG RPKGVTVDHR
660 670 680 690 700
GLSRLLQAHR RVTFSRIRPS AGGPGRAAHV SSFSFDASWD PLLAMVAGHE
710 720 730 740 750
LHMIDEDLRF DPPGVVAYFR DRRIDYVDLT PTYFRSLLDA GLLEEGFPCP
760 770 780 790 800
SLVALGGEAM DGELWERLRA AAPRVTAMNT YGPTETAVDA VVTVLGDLPP
810 820 830 840 850
GTIGRPVPRW RAYVLDAGLR PVPPGVLGEL YLAGPGVARG YLGQHALTAE
860 870 880 890 900
RFVACPFGKP GERMYRTGDL ARWLPDGHLV YVGRGDEQVK IRGFRIEPGE
910 920 930 940 950
VEAALRELEG VAAAAVTVRE DTPGTRRLVG YVVGTPDADD ARLRPAEVLA
960 970 980 990 1000
RLRDRLPDHL VPSAFVRLRE LPVNTSGKLD RAALPAPDPA DFPAGRRPRT
1010 1020 1030 1040 1050
ALEREVCALF AEVLGAGSVG IDDDFFGRGG DSILSIQLVG SARRAGLTFT
1060 1070 1080 1090 1100
VRQVFELRTP AALAAAARRT DAAGDEDPAL AVGPLPLLPV VAETLAAGGP
1110 1120 1130 1140 1150
VHSYNQSVVL ASPPDAAPDD VRDALQALLD RHDALRVHAA PAAGPGRLWD
1160 1170 1180 1190 1200
LRVEEAGTVA AERCLRRIDA TGMSDEELAR AQAAEAVTAR ACLDPLAGAL
1210 1220 1230 1240 1250
VSAVWFDRGD RPGRLVLVIH HLAVDGVSWR ILLGDLREAW RALRAGRRPE
1260 1270 1280 1290 1300
LPRTGTSLRT WATRLTERAT DPAVTAQLDH WTATLADGPA PGSRPLDRTR
1310 1320 1330 1340 1350
DTVATSAVLS GELPASLTTD LLGPAPAAFR AGVNDLLLTA FALAVAHWRG
1360 1370 1380 1390 1400
EEDAPVLVDL ESHGRTEELV PGADLSRTVG WFTSVHPVRL AAGRVTAADL
1410 1420 1430 1440 1450
AERAPAVGDA IKRIKEQLRA VPDGGLGHGL LRHLNPDTAP RLRGLARARF
1460 1470 1480 1490 1500
GFNYLGRFAA EQGAGEDSWP LLGSGPAGQH PDTPLDHEIE VNVVTAEGPD
1510 1520 1530 1540 1550
GPRLITRWTY ATGLLTEEEV RRLTRSWSLA LHAVVGHATA EGAGGLSPSD
1560 1570 1580 1590 1600
VAVPDLGQAE IEQLERRTGT ALEDILPVAP LQEGLLFHSV YDRRALDVYV
1610 1620 1630 1640 1650
GQLAFRLEGE IDQDALRTAA AALLARHTSL RTGFHQRESG QWVQAVARSV
1660 1670 1680 1690 1700
ELPWQFHDLL DPHGAGGAAG AADAGSGRRW EELAAAERVE RFDLTRPPLV
1710 1720 1730 1740 1750
RFLLARTAPE RYQFVITTHH TIVDGWSIPI LLRELLALYG GDPLPPAPGH
1760 1770 1780 1790 1800
RLHADWLAAR DLVAAREAWT RALADTEGPT LLAPGAPRVG EVPRSVRLNL
1810 1820 1830 1840 1850
PEEVSARLLT RAREAGATLN SVVQAVWALV LAQETGRSDV TFGITVSGRP
1860 1870 1880 1890 1900
AELPGAENLV GMLVNKVPLR VRLRPAEPLM ELARRLEREQ LELLEHQHVP
1910 1920 1930 1940 1950
LTTLHRWSGL PELFDTTMVF ENYPAEVTAR QAPFRASGTA SYSRNHYPLT
1960 1970 1980 1990 2000
LVGAMRGTEL TVRVDHRPDL FDEDFARSLG ERVIAALTEA ADHPFVPAGT
2010 2020 2030 2040 2050
LDLLGAEERA RLLEWGTGPA PEDAPRTYVD LFEEQAARTP DAPAVISSDG
2060 2070 2080 2090 2100
VLTYAELDRQ ANGVARWLAG RAGSAGGAEV HIGVLAPRRP EVLAVLLGVL
2110 2120 2130 2140 2150
KSGAAYVPLD EQWPAERLRT VLEDCRPALV LAPTAARSDA ARESGATVLP
2160 2170 2180 2190 2200
VDPAALAAHG PQTPTDAERI RPLTPGAAAY ALYTSGSTGR PKGVVIDHSA
2210 2220 2230 2240 2250
LAAYVGGARR RYPDAAGTSL AHTSLAFDLT VTTLLTPLTA GGAVRLGELD
2260 2270 2280 2290 2300
ETARDAGATL VKATPSHLPL LSELPGALND GGTLILGGEA LTGGRLRPWR
2310 2320 2330 2340 2350
ELHPDAQVVN AYGPTELTVN CTEYRLPKGE PVGEGPVPIG RPFAGVRVHV
2360 2370 2380 2390 2400
LGPGLRPVPA EVPGELYVSG VGVARGYLGR PALTAERFVA CPFGEPGERM
2410 2420 2430 2440 2450
YRTGDLVRWR SDGQLEYVGR SDDQVKLRGF RVETAEVARA LETCPSVGSA
2460 2470 2480 2490 2500
MVVLREDQPG DQRLVGYLVP AAGSGALDKE AVSDAVRAVL PEYMVPSALV
2510 2520 2530 2540 2550
VLEDGPPLTV NGKVDRSALP APEAEPARSA GRAPRGPREE ILCGLFADVL
2560 2570 2580 2590 2600
GVRAVGVDDD FFALGGHSLL AIVVISRIRA LLDVDVAIDA LFEAPTVARL
2610 2620 2630 2640 2650
AAHLDGPGRG HGAVRPAVPR PGRLPLSYAQ LRLWLLHQIE GPSATYTIPL
2660 2670 2680 2690 2700
ALRLTGPLDV AALRAALGDV VARHESLRTV FAEDEHGPHQ IVLAPGDAEP
2710 2720 2730 2740 2750
GLKAVPTTED RLRSDLEAEA ARPFDLGQAP PVHARLFVLD ERTHVLLLAV
2760 2770 2780 2790 2800
HHIAMDGWSV RPLVRDLASA YAARRRGASL DLPALPVQYA DYTLWQHEEL
2810 2820 2830 2840 2850
GSEDDPDSPL AAQLRYWRRT LDGLPQESAP AADRPRPATP SYRGGRVALT
2860 2870 2880 2890 2900
VPPELHGRVV ELAREFRATP FMVVHAALAA LLTRLGAGTD VPIGSPVAGR
2910 2920 2930 2940 2950
VDDALEDLVG FFVNTLVLRT DTSGDPTFGE LLERVRATDL GAYAHQDLPF
2960 2970 2980 2990 3000
ERLVEVLNPE RSLARHPLFQ ILLAFNNGAA PDEGPADRAS DVLVRPETVE
3010 3020 3030 3040 3050
IAAAKFDLSL SFNEDRAADG TAAGMRGVLE YSADLYDEST ARRMAERYLR
3060 3070 3080 3090 3100
LLEAAVAEPR TPLSRIPVLS EAELHDVLVR RNDTGRTRPD SSPLRRFEAQ
3110 3120 3130 3140 3150
AATTPRATAL VVGEERLDYA ELDARAERLA TLLSRSTAGR GGPVAVALPR
3160 3170 3180 3190 3200
GVMLPVALLA VWKAGLHYLP LDPDHPRSRL ADVLADSAPG CVITTTDLAR
3210 3220 3230 3240 3250
RLPPVPAPLL VLDDPATAAR LAATTATALA EDPREQNGEW GEELAYTIYT
3260 3270 3280 3290 3300
SGSTGRPKGV MVTRSAVANF LADMNERLEL GPGDRLLAVT TVSFDIAVLE
3310 3320 3330 3340 3350
LLAPLLTGGT VVLADATTQR DPAAVRSLCA REGVTVIQAT PSWWHAMAVD
3360 3370 3380 3390 3400
GGLDLTALRV LVGGEALPPA LARTLLEPGR APLGDYLLNL YGPTETTVWS
3410 3420 3430 3440 3450
TVARITADSL EAHGGAVPTG TPIARTAAYV LDAALRPVPD GVPGELYLAG
3460 3470 3480 3490 3500
AGLARGYLGR PGMTAERFVA CPFGEPGERM YRTGDLARWR ADGNLEHLGR
3510 3520 3530 3540 3550
TDDQVKVRGF RIELGEVERA LTQAHGVGRA AAAVHPDAAG SARLVGYLVP
3560 3570 3580 3590 3600
AGGSGALDEK AVADAVRAVL PAYMVPSALV VLDGGLPLTA NGKLDRAALP
3610 3620 3630 3640 3650
APEATTGRGP GRAPRGPREE ILCGLFADVL GVPAVGVDDD FFALGGHSLL
3660 3670 3680 3690 3700
ATRLIARVRG TLGVELGVRE VFETPTVAGL AAALSAAGEA GPRLRPADPR
3710 3720 3730 3740 3750
PERLPLSHAQ RRLWFVRQLE GPSATYNVPW ALRLTGPLDV AALRAALGDV
3760 3770 3780 3790 3800
VARHESLRTV FAEDEHGPHQ VVLSADGPAP LSGPVRTDED ALPRLLREAA
3810 3820 3830 3840 3850
DHAFRLDAEP PLRAHLFATA PEDHTLLLVM HHIATDAWSQ RPLIADLAAA
3860 3870 3880 3890 3900
YAARHAGRVP TLPPLPVAYA DYALWQQARL GDEREKDSAL SAQLAYWRDA
3910 3920 3930 3940 3950
LAGSPEELAL PADRPRPAVP SHRGDSVPLT VPPELHGRVV ELAREFRATP
3960 3970 3980 3990 4000
FMVVHAALAA LLTRLGAGTD VPIGSPVAGR VDDALEDLVG FFVNTLVLRT
4010 4020 4030 4040 4050
DTSGDPTFGE LLERVRATDL GAYAHQDLPF ERLVELRDPE RSLARHPLFQ
4060 4070 4080 4090 4100
VSLNYDTAET ARARDAAPEL DGLTVSGRPL GVTTSKFDLT FALTETRAHD
4110 4120 4130 4140 4150
GGPAGLRGAL EYSTDLFDRG TAERLAERFA RVLQAAVAAP GTRLDQIDVL
4160 4170 4180 4190 4200
LPGERALLEG EWSRPEPGPV APTDDARFPD LFEAQAARTP HAPAVRDGDR
4210 4220 4230 4240 4250
ELSYAELNDR ANRLARFLAA RGAGPEDTVA VLLPRGPELI TALVAVQKAG
4260 4270 4280 4290 4300
AAYVPMDAEL PAERIAHMLE NARPVLVLAH TATQDALPEG AGPVVRLDAP
4310 4320 4330 4340 4350
AIEAALAGLD GGDCTDADRR APATHHDPAY VVYTSGSTGT PKGVVVEQRS
4360 4370 4380 4390 4400
LAAFLVRSAA RYRGAAGTAL LHGSPAFDLT VTTLFTPLIA GGCIVVADLD
4410 4420 4430 4440 4450
APERDAPARP DLLKVTPSHL ALLDTIASWA TPAADLVVGG EQLTASRLAR
4460 4470 4480 4490 4500
LRRAHPDMRV FNDYGPTEAT VSCADFVLEP GDAPPTDTVP IGRPLAGHRL
4510 4520 4530 4540 4550
FVLDDRLRPV PANVPGELYV SGVGVARGYL GRPGMTAERF VACPFGEPGE
4560 4570 4580 4590 4600
RMYRTGDLAR RRADGNLEYL GRRDGQVKVR GFRVETGEIE TALLDRPEIG
4610 4620 4630 4640 4650
QAAVVLRGER LLAYVAAPPE RFDPDALRQA LASRLPRYMV PAAFVRLDAL
4660 4670 4680 4690 4700
PLAPGGKLDH RALPEPPAPA DAPHGSRPPR DAWEGVLCEA FGEVLGIAEV
4710 4720 4730 4740 4750
GADDDFFALG GDSIGSIRLV GRVRAAGGRM TVRDIFEQRT PAALAGRSRP
4760 4770 4780 4790 4800
GGPATEVLGG RGTGPVEPTP ISSWLAELGG AVDGYNQSVL LRVPAEADAA
4810 4820 4830 4840 4850
VVTGALQTLL DHHDALRMRA EPEDGHWRME IAEAGAVDAA TVLERVDAAG
4860 4870 4880 4890 4900
ADQGELDRLV RTHCAAARDR LAPQKGSVLR AVWFDGGPRE PGHLALVAHH
4910 4920 4930 4940 4950
LVVDGVSWRI LTADLGSAWQ ALAEGREPHL DPVGTPLRIW ARHLAELAAD
4960 4970 4980 4990 5000
PRRAERCAHW EEQSPRPWET GGLDPALDDR STEEALSLTL PAAATRAVLG
5010 5020 5030 5040 5050
PVPAALGVGV SEVLLGTFAA AVRRRRPAEA ADGVTVDLEG HGREEDVVPG
5060 5070 5080 5090 5100
ADLSRTVGWF TAAHPVRVPA ARPDEDRTGA LRALAAILDR APDAGLGYGL
5110 5120 5130 5140 5150
LRYLNPRTRQ RLAALPAPRY GFNYLGRFGG SGEDRDADDR TSNWSPVAAG
5160 5170 5180 5190 5200
LAGQPAQLPL AHEIEVTAVA VEGPEGPRLI ATWSWAGRLH RERDVRELAE
5210 5220 5230 5240
LWFRELEELA SAEPPPAGPP PLSDPPPLVE LTDTELDQLE AEWKAG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ118863 Genomic DNA Translation: AAZ23077.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ118863 Genomic DNA Translation: AAZ23077.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
Gene3Di | 1.10.1200.10, 4 hits 3.30.300.30, 4 hits 3.30.559.10, 6 hits |
InterProi | View protein in InterPro IPR010071, AA_adenyl_domain IPR036736, ACP-like_sf IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR010060, NRPS_synth IPR020806, PKS_PP-bd IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site |
Pfami | View protein in Pfam PF00501, AMP-binding, 4 hits PF13193, AMP-binding_C, 4 hits PF00668, Condensation, 6 hits PF00550, PP-binding, 4 hits |
SMARTi | View protein in SMART SM00823, PKS_PP, 4 hits |
SUPFAMi | SSF47336, SSF47336, 4 hits |
TIGRFAMsi | TIGR01733, AA-adenyl-dom, 4 hits TIGR01720, NRPS-para261, 2 hits |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 2 hits PS50075, CARRIER, 4 hits PS00012, PHOSPHOPANTETHEINE, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q45R83_STRFR | |
Accessioni | Q45R83Primary (citable) accession number: Q45R83 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 13, 2005 |
Last sequence update: | September 13, 2005 | |
Last modified: | January 19, 2022 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |