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Entry version 70 (31 Jul 2019)
Sequence version 1 (13 Sep 2005)
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Protein
Submitted name:

Peptide synthetase

Gene

lptD

Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
strfr-q45r82 Thioesterase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Peptide synthetaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lptDImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces fradiae (Streptomyces roseoflavus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1906 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1008O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2067O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini973 – 1048CarrierInterPro annotationAdd BLAST76
Domaini2032 – 2107CarrierInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2013 – 2035DisorderedSequence analysisAdd BLAST23

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.30.559.10, 2 hits
3.40.50.12780, 2 hits
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR029058 AB_hydrolase
IPR036736 ACP-like_sf
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR020802 PKS_thioesterase
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR001031 Thioesterase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 2 hits
PF13193 AMP-binding_C, 2 hits
PF00668 Condensation, 2 hits
PF00550 PP-binding, 2 hits
PF00975 Thioesterase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823 PKS_PP, 2 hits
SM00824 PKS_TE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 2 hits
SSF53474 SSF53474, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733 AA-adenyl-dom, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS50075 CARRIER, 2 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q45R82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGSLQDVLP LSPLQEGLLF HSEYVGDEAV DVYTVQTEVE LRGPLDVPAL
60 70 80 90 100
RAAAEAVLRR HDNLRAGFAT RALKDPVQFV PREVELPWEE ADLRAADDPD
110 120 130 140 150
AEAARRLEEH RWRRFRPSKP PLVRFLLLRT AHDRHRFALT NHHILLDGWS
160 170 180 190 200
MPMLLRELML LYRTGGDASA LPPVRRYRDY LAWLGGRDRG TAREAWRAAL
210 220 230 240 250
AGLEAPTLIA PRADRAAEAP TWLDFTLSET ASAGLSAAAR AAGLTLNTVV
260 270 280 290 300
QGLWALTLAR TTGSQDVVYG VVVSGRPPEL DGVESMIGLF ANTVPLRARM
310 320 330 340 350
PVDEPLTDFL RRLQREQSAL LDHQHLRLAD IQRLAGQGEL FDSVMAFENY
360 370 380 390 400
PDGPADEPSG ASADTPGHVR VVASRMRDAM HYPLGLLASP GTRMRFRLGH
410 420 430 440 450
RPSAVTPRLA AALRDRLLRL VDAFLATPHL PLGRFDVLDD AERALVLDTF
460 470 480 490 500
NDTAHEVEDT TAVELFLRQA ARTPARIAVE TADRSVDYAR LADRSGRLAR
510 520 530 540 550
LLAEHGARAE RFVALVLPRS PELVETALAV WQTGAAYVPV DPAHPADRMA
560 570 580 590 600
RLLREADPVL TVTTADLADR LPAGLPLLVL DGPSTAAALQ ALPGGPLTAS
610 620 630 640 650
ELPAPVDPRN AAYALYTSGS TGRPKGVVAT HRSLVGYLLR GSAQYPSDGR
660 670 680 690 700
SLVHSPVSFD LTVGALYVPL ISGGTVRLAS LDDEPVLRPG ETPPDFVKVT
710 720 730 740 750
PSHLPVLEGL PGEVSPTGAI TFGGEQLTGR HLRRWRADHP DVTVYNVYGP
760 770 780 790 800
TETTVNCSEH RIAPRDPVGD GPVPIGRPLW NTRLFVLGPG LAPVPVGVPG
810 820 830 840 850
ELYVAGAGLT RGYLRDPGRT AERFVACPYA AGQRMYRTGD LVRWNEDGLL
860 870 880 890 900
EYLGRVDDQI SLRGFRVEPG EVEAALAAHP AVRRAAVVLR EDTPGDARLV
910 920 930 940 950
AYAVPAEPEG ARSTPPSPLP TEQILEHLRR TLPPYMVPAH LVELPALPVT
960 970 980 990 1000
PHGKIDRAAL PEPSVAGAPA GGAPRSPREE ILCGIFAEVL RRPRVSIDDD
1010 1020 1030 1040 1050
FFALGGHSLL ATRLASRVRA ALDTELPVRR LFEHPTVRSL SALLDPDAGR
1060 1070 1080 1090 1100
RPAVTPARRP EHVPLSFSQQ RLWIMHRLTG PDATYNIHRA LRLDGDLDVP
1110 1120 1130 1140 1150
ALEAALHDVT ERHETLRTVF PEGPEGPYQK VLPARREDGT LTVLPVADRE
1160 1170 1180 1190 1200
VDRTLAELAA HRFDLESEPP KRAWLLESGP RSRVLVLVLH HIASDGWSGR
1210 1220 1230 1240 1250
RLLRDLFTAY TARRAGRAPQ WRPLPVQYAD YALWQRRHLG DPADPASPAA
1260 1270 1280 1290 1300
VQGEYWEKQL AGLPEELRLP ADRPRPARPT RTGGQVWLTL PATAHAAVAE
1310 1320 1330 1340 1350
LARTSRASVF MVVQAAVAAF LTRMGAGEDI PIGAPVAGRT DEAVEELVGF
1360 1370 1380 1390 1400
FVSTLVLRTD TSGDPSFTEL VGRVRETALA AYAHQDLPFE YVVERLSPTR
1410 1420 1430 1440 1450
SLGRHPLFQV ALSCNNTEEQ LGRQGAPPPG LSVTPHQVDA ARSKFDLMFT
1460 1470 1480 1490 1500
FLENHGEDGQ PTGIETALEY SADLFDRETA QSLLDRFARM LAIWAAEPAA
1510 1520 1530 1540 1550
AIGARELLAA DERHTVVTAW NATRRADLVA TLPRMFEEQV ARTPHATALE
1560 1570 1580 1590 1600
HAGHHLTYAE LNARANRLAR VLVRRGIRPE HRVAILMPRS VEQITALLAI
1610 1620 1630 1640 1650
TKAGGAAVPV DPGHPGQRIA FMLRDSACAL ILADHPHAAG REEIAGVPVL
1660 1670 1680 1690 1700
VPADEPAPER ATDLADGDRN APLTAGHAAY VVYTSGSTGR PKGVVTEHRG
1710 1720 1730 1740 1750
LLSLATAQRE RYPVGPGSRV LQLASPSFDG AVLELLMALT TGGTLVLPDG
1760 1770 1780 1790 1800
PLLAGQPLAD MLAEHRISHA FIPPAVLSGL PSEGLEGLRC LVVGGEAVTA
1810 1820 1830 1840 1850
PLTDRWAPGR RMLNIYGPTE TTAVTLTSEA LTPGGPPPAI GTPVPNTRAH
1860 1870 1880 1890 1900
VLDDRLRPVP PGVTGELYLA GASLARGYGR RPALTASRYV GCPFGAPGER
1910 1920 1930 1940 1950
MYRTGDLARL DREGRVHHMG RTDEQIKLRG FRVEPGEIRA RLTEHPAVRE
1960 1970 1980 1990 2000
AAVVLRDDGP GGRALVAYAV PADGPPRPTA AQLRAHLNAL LPPYMVPAAF
2010 2020 2030 2040 2050
LVLDALPTTP NGKLDREALP APQPHAEETG RPPRDEREAA LCEVFAEVLE
2060 2070 2080 2090 2100
RTSLGADDGF FENGGHSLLA VRLVARVRER LGVPLAARDL FEAPTPAALA
2110 2120 2130 2140 2150
ERLARGAERR APAPLLTLRG RGDRPPLFCV HPAVGLGWAY ASLLPWLPAD
2160 2170 2180 2190 2200
VPLHALQART PADGAGLPGS VEEMAEDYVR LIRRVRPHGP YRLLGWSLGA
2210 2220 2230 2240 2250
HVAHTAAALL ERDGQRVDLL AMLDAYPPHR TGDPGGRAEE SEAEIVAANL
2260 2270 2280 2290 2300
RESGFAWDED EQRAGRFPLE RFRAHLRRVD SSLGHLDDAE LTAAKDVYVN
2310 2320 2330 2340 2350
NVRLMRSFTP GRVRCGIVLM TAERTRSLDP AAWEPHTEGG VEVHRLDASH
2360 2370 2380
MSMLTEPASV AAAGRLLTHR LESLRGATTK KREV
Length:2,384
Mass (Da):258,697
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B262604DC024B89
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ118863 Genomic DNA Translation: AAZ23078.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ118863 Genomic DNA Translation: AAZ23078.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

ESTHERistrfr-q45r82 Thioesterase

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.30.559.10, 2 hits
3.40.50.12780, 2 hits
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR029058 AB_hydrolase
IPR036736 ACP-like_sf
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR020802 PKS_thioesterase
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR001031 Thioesterase
PfamiView protein in Pfam
PF00501 AMP-binding, 2 hits
PF13193 AMP-binding_C, 2 hits
PF00668 Condensation, 2 hits
PF00550 PP-binding, 2 hits
PF00975 Thioesterase, 1 hit
SMARTiView protein in SMART
SM00823 PKS_PP, 2 hits
SM00824 PKS_TE, 1 hit
SUPFAMiSSF47336 SSF47336, 2 hits
SSF53474 SSF53474, 1 hit
TIGRFAMsiTIGR01733 AA-adenyl-dom, 2 hits
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS50075 CARRIER, 2 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ45R82_STRFR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q45R82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: July 31, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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