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Entry version 83 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Botulinum neurotoxin type F nontoxic-nonhemaglutinin component

Gene

ntnh

Organism
Clostridium botulinum
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeurotoxinImported, Toxin
Biological processVirulenceARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Botulinum neurotoxin type F nontoxic-nonhemaglutinin componentImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ntnhImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiClostridium botulinumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1491 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaEubacterialesClostridiaceaeClostridium

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 270Peptidase_M27InterPro annotationAdd BLAST268
Domaini815 – 989Toxin_R_bind_NInterPro annotationAdd BLAST175
Domaini999 – 1163NTNH_CInterPro annotationAdd BLAST165

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the botulism non-toxic nonhemagglutinin family.ARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000395, Bot/tetX_LC
IPR036248, Clostridium_toxin_transloc
IPR013320, ConA-like_dom_sf
IPR013677, Nontoxic_nonhemagglutn_C
IPR012928, Toxin_rcpt-bd_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08470, NTNH_C, 1 hit
PF01742, Peptidase_M27, 1 hit
PF07953, Toxin_R_bind_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00760, BONTOXILYSIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit
SSF58091, SSF58091, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q45887-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKINDDLNIN SPVDNKNVVI VRARKTNIFF KAFQVAPNIW VAPERYYGEP
60 70 80 90 100
LNISDQEKSD GGIYDENFLK ENSEKEEFLQ AIILLLKRIN NNIIGQKLLS
110 120 130 140 150
LMCTSIPFLH EYKQGDYRQS NYLGSKNSEY LYSANIVIFG PGSNIVKNNT
160 170 180 190 200
IYYKKNFAEN GMGTMAEILF QPFLTYKYNQ FYADPALELI KCLIKAIYFL
210 220 230 240 250
YGIKPNDNLN IPYRLRNEFS NVEYSELNII DFLISGGIDY KFINTNPYWF
260 270 280 290 300
IDNYFIDVPK VFEKHKNDYE INIKNNSEIG TSIKLYLEQK FKTNVQDIWE
310 320 330 340 350
LNLSYFSKEF QIMMPEKHNN ALKHYYRKEY YKINYSKQYD INGFVNGQIA
360 370 380 390 400
TKLLLSEKNQ YIINKPQLII NLINKSNNSL LMKSNIYGDG LNGTTDNFYR
410 420 430 440 450
NYKIPDNIAY QYHPNNTYLD NVNIEEINNI PQITDADIYP YTNNCDTFIP
460 470 480 490 500
IYNITQSREI NTTVPYSINY LQSQIMNSDD ITLSSDFWEV VCSNDKSLVY
510 520 530 540 550
SYLDNVINYL DSIKNNTPIN TDKKYYLWLK EIFRNYSFDI TATEEITTEC
560 570 580 590 600
GINKIVSWFG KAFNILNTDN SFKIEFQNSG AIALINKKDN IIIPKIEIDE
610 620 630 640 650
MPNSMLNLSF EDLNEQLYSI YSKNITYFKK IYYNFLDQWW TEYYSQYFDL
660 670 680 690 700
ICMAKKSILA QENLIKKIIQ KKISYLIGAS NIPDDILAVM RLTTTNTLRD
710 720 730 740 750
ISVESQIAMN NLNNFLNKAA MCVFQSNIYP KFISFMEQCI KHINKSTKEF
760 770 780 790 800
IQKCTNINET EKLQLIMQNS FSNLDFDFLD IQNMKNLFNS YTELLIKEQT
810 820 830 840 850
SPYELSLYAF EEQDNNVIGD ASGKNTLVEY PKGIELVYGI NNSALYLNGS
860 870 880 890 900
NQSIIFTNDY FENGLTNSFS IYFWLRNLGQ DTIKSKLIGS KEYNCGWEIY
910 920 930 940 950
FQEIGHVFNM IDSNGNEKNI YLSDVSNNSW HYITISVDRL KEQLLIFIDD
960 970 980 990 1000
NLVVNESIKD ILNIYSSNII SLLSDNKASY IEGLTILNKP TTGEEVLRNY
1010 1020 1030 1040 1050
FKNLNNSYVR DSNDERLEYN KTYQLYDYVF PDNPICEVKQ DNNIYLTINN
1060 1070 1080 1090 1100
INNLNMKPCK FKLLSINSNK QYVQKWDEVI ISVLYDTEKY VCISNENNRV
1110 1120 1130 1140 1150
KIIDNKIMQV KFIISNDIFI SNCLTHAHNN KYICLSMKDE NYNWMICNNE
1160
SNIPKKAYLW ILKEV
Length:1,165
Mass (Da):136,527
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i312AC293EFDF1C65
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X71086 Genomic DNA Translation: CAA50404.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I40644

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71086 Genomic DNA Translation: CAA50404.1
PIRiI40644

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.20.1120.10, 1 hit
InterProiView protein in InterPro
IPR000395, Bot/tetX_LC
IPR036248, Clostridium_toxin_transloc
IPR013320, ConA-like_dom_sf
IPR013677, Nontoxic_nonhemagglutn_C
IPR012928, Toxin_rcpt-bd_N
PfamiView protein in Pfam
PF08470, NTNH_C, 1 hit
PF01742, Peptidase_M27, 1 hit
PF07953, Toxin_R_bind_N, 1 hit
PRINTSiPR00760, BONTOXILYSIN
SUPFAMiSSF49899, SSF49899, 1 hit
SSF58091, SSF58091, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ45887_CLOBO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q45887
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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