UniProtKB - Q45064 (PLSY_BACSU)
Protein
Glycerol-3-phosphate acyltransferase
Gene
plsY
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO4) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.3 Publications
Catalytic activityi
- EC:2.3.1.275
Activity regulationi
Inhibited by acyl-CoA.1 Publication
: phospholipid metabolism Pathwayi
This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.
GO - Molecular functioni
- acyl-phosphate glycerol-3-phosphate acyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- phospholipid biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
BioCyci | BSUB:BSU18070-MONOMER |
UniPathwayi | UPA00085 |
Protein family/group databases
TCDBi | 9.B.31.1.2, the plsy/yqih (plsy) family |
Names & Taxonomyi
Protein namesi | Recommended name: Glycerol-3-phosphate acyltransferaseAlternative name(s): Acyl-PO4 G3P acyltransferase Acyl-phosphate--glycerol-3-phosphate acyltransferase Lysophosphatidic acid synthase Short name: LPA synthase |
Gene namesi | Name:plsY Synonyms:yneS Ordered Locus Names:BSU18070 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
- Cell membrane Curated; Multi-pass membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2 – 22 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 54 – 74 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 76 – 96 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 111 – 131 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 153 – 173 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000188326 | 1 – 193 | Glycerol-3-phosphate acyltransferaseAdd BLAST | 193 |
Proteomic databases
PaxDbi | Q45064 |
PRIDEi | Q45064 |
Interactioni
Subunit structurei
Probably interacts with PlsX.
1 PublicationProtein-protein interaction databases
STRINGi | 224308.BSU18070 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PlsY family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0344, Bacteria |
InParanoidi | Q45064 |
OMAi | WRHRGNL |
PhylomeDBi | Q45064 |
Family and domain databases
HAMAPi | MF_01043, PlsY, 1 hit |
InterProi | View protein in InterPro IPR003811, G3P_acylTferase_PlsY |
PANTHERi | PTHR30309, PTHR30309, 1 hit |
Pfami | View protein in Pfam PF02660, G3P_acyltransf, 1 hit |
SMARTi | View protein in SMART SM01207, G3P_acyltransf, 1 hit |
TIGRFAMsi | TIGR00023, TIGR00023, 1 hit |
i Sequence
Sequence statusi: Complete.
Q45064-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLIALLIILA YLIGSIPSGL IVGKLAKGID IREHGSGNLG ATNAFRTLGV
60 70 80 90 100
KAGSVVIAGD ILKGTLATAL PFLMHVDIHP LLAGVFAVLG HVFPIFAKFK
110 120 130 140 150
GGKAVATSGG VLLFYAPLLF ITMVAVFFIF LYLTKFVSLS SMLTGIYTVI
160 170 180 190
YSFFVHDTYL LIVVTLLTIF VIYRHRANIK RIINKTEPKV KWL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73234 Genomic DNA Translation: CAA97604.1 AL009126 Genomic DNA Translation: CAB13690.1 |
PIRi | A69892 |
RefSeqi | NP_389689.1, NC_000964.3 WP_003231560.1, NZ_JNCM01000035.1 |
Genome annotation databases
EnsemblBacteriai | CAB13690; CAB13690; BSU18070 |
GeneIDi | 938037 |
KEGGi | bsu:BSU18070 |
PATRICi | fig|224308.179.peg.1969 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73234 Genomic DNA Translation: CAA97604.1 AL009126 Genomic DNA Translation: CAB13690.1 |
PIRi | A69892 |
RefSeqi | NP_389689.1, NC_000964.3 WP_003231560.1, NZ_JNCM01000035.1 |
3D structure databases
SMRi | Q45064 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU18070 |
Protein family/group databases
TCDBi | 9.B.31.1.2, the plsy/yqih (plsy) family |
Proteomic databases
PaxDbi | Q45064 |
PRIDEi | Q45064 |
Genome annotation databases
EnsemblBacteriai | CAB13690; CAB13690; BSU18070 |
GeneIDi | 938037 |
KEGGi | bsu:BSU18070 |
PATRICi | fig|224308.179.peg.1969 |
Phylogenomic databases
eggNOGi | COG0344, Bacteria |
InParanoidi | Q45064 |
OMAi | WRHRGNL |
PhylomeDBi | Q45064 |
Enzyme and pathway databases
UniPathwayi | UPA00085 |
BioCyci | BSUB:BSU18070-MONOMER |
Family and domain databases
HAMAPi | MF_01043, PlsY, 1 hit |
InterProi | View protein in InterPro IPR003811, G3P_acylTferase_PlsY |
PANTHERi | PTHR30309, PTHR30309, 1 hit |
Pfami | View protein in Pfam PF02660, G3P_acyltransf, 1 hit |
SMARTi | View protein in SMART SM01207, G3P_acyltransf, 1 hit |
TIGRFAMsi | TIGR00023, TIGR00023, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLSY_BACSU | |
Accessioni | Q45064Primary (citable) accession number: Q45064 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families