Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 97 (11 Dec 2019)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Mannuronan C5-epimerase AlgE5

Gene

algE5

Organism
Azotobacter vinelandii
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts beta-D-mannuronic acid (M) to alpha-L-guluronic acid (G), producing a polymer with gel-forming capacity, required for the formation of the cyst coat.By similarity

Miscellaneous

Each enzyme of this family of C5 epimerases introduces its own characteristic sequence distribution of G-blocks in their substrates, explaining the extensive sequence variability of alginates. These alginates of varying composition have different physical properties and are necessary at different stages of the bacterium life cycle.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by zinc.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: alginate biosynthesis

This protein is involved in the pathway alginate biosynthesis, which is part of Glycan biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway alginate biosynthesis and in Glycan biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processAlginate biosynthesis
LigandCalcium

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00286

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mannuronan C5-epimerase AlgE5Curated (EC:5.1.3.37By similarity)
Alternative name(s):
Poly(beta-D-mannuronate) C5 epimerase 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:algE51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAzotobacter vinelandii
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri354 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • Secreted
  • Note: Probably exported via the hemolysin-type secretion pathway.

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002195591 – 997Mannuronan C5-epimerase AlgE5Add BLAST997

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q44492

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Produced during vegetative growth and in encysting cells.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q44492

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati133 – 155PbH1 1Sequence analysisAdd BLAST23
Repeati157 – 179PbH1 2Sequence analysisAdd BLAST23
Repeati180 – 202PbH1 3Sequence analysisAdd BLAST23
Repeati204 – 226PbH1 4Sequence analysisAdd BLAST23
Repeati257 – 279PbH1 5Sequence analysisAdd BLAST23
Repeati280 – 315PbH1 6Sequence analysisAdd BLAST36
Repeati320 – 359PbH1 7Sequence analysisAdd BLAST40
Repeati388 – 403Hemolysin-type calcium-binding 1Sequence analysisAdd BLAST16
Repeati406 – 422Hemolysin-type calcium-binding 2Sequence analysisAdd BLAST17
Repeati424 – 439Hemolysin-type calcium-binding 3Sequence analysisAdd BLAST16
Repeati557 – 573Hemolysin-type calcium-binding 4Sequence analysisAdd BLAST17
Repeati574 – 590Hemolysin-type calcium-binding 5Sequence analysisAdd BLAST17
Repeati695 – 709Hemolysin-type calcium-binding 6Sequence analysisAdd BLAST15
Repeati712 – 729Hemolysin-type calcium-binding 7Sequence analysisAdd BLAST18
Repeati828 – 839Hemolysin-type calcium-binding 8Sequence analysisAdd BLAST12
Repeati846 – 862Hemolysin-type calcium-binding 9Sequence analysisAdd BLAST17
Repeati864 – 880Hemolysin-type calcium-binding 10Sequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of one catalytically active A module and four R modules.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the D-mannuronate C5-epimerase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107MV2 Bacteria
ENOG410XQTW LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.150.10.10, 4 hits
2.160.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039448 Beta_helix
IPR006633 Carb-bd_sugar_hydrolysis-dom
IPR018511 Hemolysin-typ_Ca-bd_CS
IPR001343 Hemolysn_Ca-bd
IPR006626 PbH1
IPR024535 Pectate_lyase_SF_prot
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR011049 Serralysin-like_metalloprot_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13229 Beta_helix, 1 hit
PF00353 HemolysinCabind, 4 hits
PF12708 Pectate_lyase_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00722 CASH, 2 hits
SM00710 PbH1, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51120 SSF51120, 4 hits
SSF51126 SSF51126, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00330 HEMOLYSIN_CALCIUM, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q44492-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYNVKDFGA LGDGVSDDTA AIQAAIDAAY AAGGGTVYLP AGEYRVSGGE
60 70 80 90 100
EPSDGCLTIK SNVYIVGAGM GETVIKLVDG WDQDVTGIVR SAYGEETSNF
110 120 130 140 150
GMSDLTLDGN RDNTSGKVDG WFNGYIPGED GADRDVTLER VEIREMSGYG
160 170 180 190 200
FDPHEQTINL TIRDSVAHDN GLDGFVADFQ IGGVFENNVS YNNDRHGFNI
210 220 230 240 250
VTSTNDFVLS NNVAYGNGGA GLVIQRGSYD VAHPYGILID GGAYYDNGLE
260 270 280 290 300
GVQIKMAHDV TLQNAEIYGN GLYGVRVYGA EDVQILDNYI HDNSQSGSYA
310 320 330 340 350
EILLQSYDDT AGVSGNFYTT TGTWIEGNTI VGSANSTYGI QERADGTDYS
360 370 380 390 400
SLYANSVSNV QSGSVRLYGT NSVVSDLPGT GQQATLEGTT GNDTLTGSEA
410 420 430 440 450
HETLLGLDGN DRLNGGAGND ILDGGAGRDN LTGGAGADLF RVSARTDSYR
460 470 480 490 500
TDSASFNDLI TDFDPAQDRI DLSALGFTGL GDGYNGTLAV VLNSAGTRTY
510 520 530 540 550
LKSYEADAEG RRFEIALDGN FAGLLDDGNL IFERPVIEGD AGNNALLGTS
560 570 580 590 600
AAETLLGHAG NDTLDGAGGD DILVGGAGRD TLTGGAGADL FRFDALSDSQ
610 620 630 640 650
RNYTTGDNQG DRIVDFSVGE DKLDVSALGF TGLGDGYNGT LAVVVNSAGD
660 670 680 690 700
RTYVKSYETD ADGYRFEFSL EGNYQDLGSE SFVFATPSGQ QLLEGSAGND
710 720 730 740 750
SLQGTAADEI VHGGAGRDTL SGGAGADVFR FSELTDSYRT ASTSFADLIT
760 770 780 790 800
DFDLADDRID LSGLGFSGLG DGYDGTLAVV VNSTGTRTYL KSYEANAAGE
810 820 830 840 850
RFEIALDGDL SAFTGANLIL DERVVLEGSD GNDTLDGGSA AEELLGGAGN
860 870 880 890 900
DSLDGGAGND ILDGGAGRDT LSGGSGSDIF RYDDALDSFR NYGTGVTGTD
910 920 930 940 950
TITDFTPGED LIDLSALGYT GLGDGYNGTL AVVLNGDGTR TYLKDRESDA
960 970 980 990
EGNQFEIALD GDLVDRLDAG DFIFAEAAAT TAIEVVGGTP TEEQLVA
Length:997
Mass (Da):103,724
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76C3E05504DCFB99
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L39013 Genomic DNA Translation: AAA87309.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I39739

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39013 Genomic DNA Translation: AAA87309.1
PIRiI39739

3D structure databases

SMRiQ44492
ModBaseiSearch...

Proteomic databases

PRIDEiQ44492

Phylogenomic databases

eggNOGiENOG4107MV2 Bacteria
ENOG410XQTW LUCA

Enzyme and pathway databases

UniPathwayiUPA00286

Family and domain databases

Gene3Di2.150.10.10, 4 hits
2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR039448 Beta_helix
IPR006633 Carb-bd_sugar_hydrolysis-dom
IPR018511 Hemolysin-typ_Ca-bd_CS
IPR001343 Hemolysn_Ca-bd
IPR006626 PbH1
IPR024535 Pectate_lyase_SF_prot
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR011049 Serralysin-like_metalloprot_C
PfamiView protein in Pfam
PF13229 Beta_helix, 1 hit
PF00353 HemolysinCabind, 4 hits
PF12708 Pectate_lyase_3, 1 hit
SMARTiView protein in SMART
SM00722 CASH, 2 hits
SM00710 PbH1, 7 hits
SUPFAMiSSF51120 SSF51120, 4 hits
SSF51126 SSF51126, 1 hit
PROSITEiView protein in PROSITE
PS00330 HEMOLYSIN_CALCIUM, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALGE5_AZOVI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q44492
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 1, 1996
Last modified: December 11, 2019
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again