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UniProtKB - Q43975 (PCAK_ACIAD)
Protein
4-hydroxybenzoate transporter PcaK
Gene
pcaK
Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Functioni
Uptake of 4-hydroxybenzoate (4-HB). Can also transport a variety of aromatic acids with hydroxyl substitutions at the 2-, 3- and 4-positions, such as salicylate, 2,4-dihydroxybenzoate, protocatechuate, 3-hydroxybenzoate, vanillate and gentisate.
1 PublicationGO - Molecular functioni
- transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: 4-hydroxybenzoate transporter PcaK1 PublicationShort name: 4-HB transporterCurated |
Gene namesi | Name:pcaK1 Publication Ordered Locus Names:ACIAD1709 |
Organismi | Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) |
Taxonomic identifieri | 62977 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Moraxellales › Moraxellaceae › Acinetobacter › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 34 | CytoplasmicCuratedAdd BLAST | 34 | |
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 56 – 72 | PeriplasmicCuratedAdd BLAST | 17 | |
Transmembranei | 73 – 93 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 94 – 101 | CytoplasmicCurated | 8 | |
Transmembranei | 102 – 122 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 123 – 128 | PeriplasmicCurated | 6 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 150 – 168 | CytoplasmicCuratedAdd BLAST | 19 | |
Transmembranei | 169 – 189 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 190 – 191 | PeriplasmicCurated | 2 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 274 | CytoplasmicCuratedAdd BLAST | 62 | |
Transmembranei | 275 – 295 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 296 – 310 | PeriplasmicCuratedAdd BLAST | 15 | |
Transmembranei | 311 – 331 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 332 – 338 | CytoplasmicCurated | 7 | |
Transmembranei | 339 – 359 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 360 – 363 | PeriplasmicCurated | 4 | |
Transmembranei | 364 – 384 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 385 – 400 | CytoplasmicCuratedAdd BLAST | 16 | |
Transmembranei | 401 – 421 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 422 – 426 | PeriplasmicCurated | 5 | |
Transmembranei | 427 – 447 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 448 – 457 | Cytoplasmic1 Publication | 10 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050320 | 1 – 457 | 4-hydroxybenzoate transporter PcaKAdd BLAST | 457 |
Interactioni
Subunit structurei
Homotrimer.
1 PublicationProtein-protein interaction databases
STRINGi | 62977.ACIAD1709 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Aromatic acid:H(+) symporter (AAHS) (TC 2.A.1.15) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2271, Bacteria |
HOGENOMi | CLU_001265_46_4_6 |
OMAi | AGMCVNG |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR004746, MFS_AAHS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00895, 2A0115, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q43975-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKEANMASQ DYATQRSSLD AQALINDAPL SRYQWLIAIV CFLIVFVDGI
60 70 80 90 100
DTAAMGFIAP ALAQDWGVDR SQLGPVMSAA LGGMIIGALV SGPTADRFGR
110 120 130 140 150
KIVLSMSMLV FGGFTLACAY STNLDSLVIF RFLTGIGLGA AMPNATTLFS
160 170 180 190 200
EYCPARIRSL LVTCMFCGYN LGMAIGGFIS SWLIPAFGWH SLFLLGGWAP
210 220 230 240 250
LILMLLVIFF LPESYRFLIV KGKNTKKVRQ ILSRIAPQKV QGVTEFHVPE
260 270 280 290 300
EKVEAGTKKG VFGMLFSAKY VKGTVLLWVT YFMGLVMIYL LTSWLPTLMR
310 320 330 340 350
ETGASLERAA FLGGLFQFGG VLSALFIGWA MDRFNPNRII AGFYLAAGIF
360 370 380 390 400
AVIVGQSLSN PTLLALFILC AGIAVNGAQS SMPVLSARFY PTQCRATGVA
410 420 430 440 450
WMSGIGRFGA VFGAWIGAVL LGNNWSFTMI LSMLIIPAAA AAIAIFVKSL
VAHTDAT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 439 | A → R in AAC37151 (PubMed:8063101).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L05770 Genomic DNA Translation: AAC37151.1 CR543861 Genomic DNA Translation: CAG68551.1 |
Genome annotation databases
EnsemblBacteriai | CAG68551; CAG68551; ACIAD1709 |
KEGGi | aci:ACIAD1709 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L05770 Genomic DNA Translation: AAC37151.1 CR543861 Genomic DNA Translation: CAG68551.1 |
3D structure databases
SMRi | Q43975 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 62977.ACIAD1709 |
Genome annotation databases
EnsemblBacteriai | CAG68551; CAG68551; ACIAD1709 |
KEGGi | aci:ACIAD1709 |
Phylogenomic databases
eggNOGi | COG2271, Bacteria |
HOGENOMi | CLU_001265_46_4_6 |
OMAi | AGMCVNG |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR004746, MFS_AAHS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00895, 2A0115, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PCAK_ACIAD | |
Accessioni | Q43975Primary (citable) accession number: Q43975 Secondary accession number(s): Q6FBL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | August 31, 2004 | |
Last modified: | February 23, 2022 | |
This is version 133 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families