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Protein

Peroxidase 64

Gene

PER64

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59Transition state stabilizerPROSITE-ProRule annotation1
Active sitei63Proton acceptorPROSITE-ProRule annotation1
Metal bindingi64Calcium 1PROSITE-ProRule annotation1
Metal bindingi67Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi69Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi71Calcium 1PROSITE-ProRule annotation1
Metal bindingi73Calcium 1PROSITE-ProRule annotation1
Binding sitei158Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi188Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi189Calcium 2PROSITE-ProRule annotation1
Metal bindingi241Calcium 2PROSITE-ProRule annotation1
Metal bindingi243Calcium 2PROSITE-ProRule annotation1
Metal bindingi248Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G42180-MONOMER

Protein family/group databases

PeroxiBasei230 AtPrx64

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 64 (EC:1.11.1.7)
Short name:
Atperox P64
Alternative name(s):
ATP17a
PRXR4
Gene namesi
Name:PER64
Synonyms:P64
Ordered Locus Names:At5g42180
ORF Names:MJC20.29
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G42180
TAIRilocus:2165820 AT5G42180

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002372923 – 317Peroxidase 64Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 111PROSITE-ProRule annotation
Disulfide bondi65 ↔ 70PROSITE-ProRule annotation
Disulfide bondi117 ↔ 313PROSITE-ProRule annotation
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi195 ↔ 227PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ43872

PTM databases

iPTMnetiQ43872

Expressioni

Tissue specificityi

Expressed in the whole plant, but preferentially in roots.

Inductioni

Pathogen and elicitor-induced. Up-regulated transiently by a cold treatment.2 Publications

Gene expression databases

ExpressionAtlasiQ43872 baseline and differential
GenevisibleiQ43872 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G42180.1

Structurei

3D structure databases

ProteinModelPortaliQ43872
SMRiQ43872
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHQ5 Eukaryota
ENOG410YE7F LUCA
HOGENOMiHOG000237556
InParanoidiQ43872
KOiK00430
OMAiMNDKTVP
OrthoDBiEOG09360GIU
PhylomeDBiQ43872

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q43872-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAHMLNLLV IVIFVVSFDV QALSPHYYDH TCPQADHIVT NAVKKAMSND
60 70 80 90 100
QTVPAALLRM HFHDCFVRGC DGSVLLDSKG KNKAEKDGPP NISLHAFYVI
110 120 130 140 150
DNAKKALEEQ CPGIVSCADI LSLAARDAVA LSGGPTWAVP KGRKDGRISK
160 170 180 190 200
AIETRQLPAP TFNISQLRQN FGQRGLSMHD LVALSGGHTL GFAHCSSFQN
210 220 230 240 250
RLHKFNTQKE VDPTLNPSFA ARLEGVCPAH NTVKNAGSNM DGTVTSFDNI
260 270 280 290 300
YYKMLIQGKS LFSSDESLLA VPSTKKLVAK YANSNEEFER AFVKSMIKMS
310
SISGNGNEVR LNCRRVR
Length:317
Mass (Da):34,706
Last modified:November 1, 1996 - v1
Checksum:i79536112BA918690
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98316 mRNA Translation: CAA66960.1
X99096 mRNA Translation: CAA67550.1
AB017067 Genomic DNA Translation: BAB08451.1
CP002688 Genomic DNA Translation: AED94776.1
AY063962 mRNA Translation: AAL36318.1
AY096403 mRNA Translation: AAM20043.1
RefSeqiNP_199033.1, NM_123583.4
UniGeneiAt.23304

Genome annotation databases

EnsemblPlantsiAT5G42180.1; AT5G42180.1; AT5G42180
GeneIDi834223
GrameneiAT5G42180.1; AT5G42180.1; AT5G42180
KEGGiath:AT5G42180

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98316 mRNA Translation: CAA66960.1
X99096 mRNA Translation: CAA67550.1
AB017067 Genomic DNA Translation: BAB08451.1
CP002688 Genomic DNA Translation: AED94776.1
AY063962 mRNA Translation: AAL36318.1
AY096403 mRNA Translation: AAM20043.1
RefSeqiNP_199033.1, NM_123583.4
UniGeneiAt.23304

3D structure databases

ProteinModelPortaliQ43872
SMRiQ43872
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G42180.1

Protein family/group databases

PeroxiBasei230 AtPrx64

PTM databases

iPTMnetiQ43872

Proteomic databases

PaxDbiQ43872

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G42180.1; AT5G42180.1; AT5G42180
GeneIDi834223
GrameneiAT5G42180.1; AT5G42180.1; AT5G42180
KEGGiath:AT5G42180

Organism-specific databases

AraportiAT5G42180
TAIRilocus:2165820 AT5G42180

Phylogenomic databases

eggNOGiENOG410IHQ5 Eukaryota
ENOG410YE7F LUCA
HOGENOMiHOG000237556
InParanoidiQ43872
KOiK00430
OMAiMNDKTVP
OrthoDBiEOG09360GIU
PhylomeDBiQ43872

Enzyme and pathway databases

BioCyciARA:AT5G42180-MONOMER

Miscellaneous databases

PROiPR:Q43872

Gene expression databases

ExpressionAtlasiQ43872 baseline and differential
GenevisibleiQ43872 AT

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER64_ARATH
AccessioniPrimary (citable) accession number: Q43872
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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