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Entry version 98 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

3-hydroxy-3-methylglutaryl coenzyme A reductase

Gene

HMG2

Organism
Raphanus sativus (Radish) (Raphanus raphanistrum var. sativus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.UniRule annotationARBA annotation This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationARBA annotation
Biological processIsoprene biosynthesisARBA annotation
LigandNADPUniRule annotationARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00058;UER00103

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3-hydroxy-3-methylglutaryl coenzyme A reductaseUniRule annotation (EC:1.1.1.34UniRule annotation)
Short name:
HMG-CoA reductaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HMG2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRaphanus sativus (Radish) (Raphanus raphanistrum var. sativus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3726 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeRaphanus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei43 – 64HelicalUniRule annotationAdd BLAST22
Transmembranei85 – 104HelicalUniRule annotationAdd BLAST20
Transmembranei528 – 553HelicalUniRule annotationAdd BLAST26

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotationARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 33Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HMG-CoA reductase family.UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00643, HMG-CoA_reductase_classI, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3270.10, 1 hit
3.30.70.420, 1 hit
3.90.770.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002202, HMG_CoA_Rdtase
IPR023074, HMG_CoA_Rdtase_cat_sf
IPR023076, HMG_CoA_Rdtase_CS
IPR004554, HMG_CoA_Rdtase_eu_arc
IPR023282, HMG_CoA_Rdtase_N
IPR009023, HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029, HMG_CoA_Rdtase_sub-bd_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10572, PTHR10572, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00368, HMG-CoA_red, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00071, HMGCOARDTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55035, SSF55035, 1 hit
SSF56542, SSF56542, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00533, HMG_CoA_R_NADP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00066, HMG_COA_REDUCTASE_1, 1 hit
PS00318, HMG_COA_REDUCTASE_2, 1 hit
PS01192, HMG_COA_REDUCTASE_3, 1 hit
PS50065, HMG_COA_REDUCTASE_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q43826-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIRRRPPKP PVNSNRFLDN RSDDDDRRKT LTSPPKASDA LPLPLYLTNA
60 70 80 90 100
VFFTLFFSVA YYLLHRWRDK IRYNTPLHVV TVTELGAIVA LIASFIYLLG
110 120 130 140 150
FFGIDFVQSF ISRPDSGDSE RDFDDHRLVT CPPPPPPSQI VAAKLPNPEQ
160 170 180 190 200
PPLPKEDEEI VKSVLDGVVP SYSLESRLGD CKRAASIRRE ALQRLTGRSI
210 220 230 240 250
EGLPLDGFDY DSILGQCCEM PVGYIQIPVG IAGPLLLDGY EYSVPMATTE
260 270 280 290 300
GCLVASTNRG CKAMYVSGGA TSTVLKDGMT RAPVVRFASA RRASELKFFL
310 320 330 340 350
ESPENFETLA VVFNRSSRFA RLQSVMCTLA GKNAYVRFSC STGDAMGMNM
360 370 380 390 400
VSKGVQNVLE FLTEDFPDMD VIGISGNFCS DKKPAAVNWI EGRGKSVVCE
410 420 430 440 450
AVIRGETVNK VLKTSVASLV ELNMLKNLTG SAIAGSLGGF NRHASNIVSA
460 470 480 490 500
VFLATGQDPA QNVESSQCIT MMEAINDGKD IHISVTMPSI EVGTVGGGTQ
510 520 530 540 550
LASQSACLNL LGVKGASKES PGMNSRRLAT IVAGAVLAGE LSLMSAIAAG
560 570
QLVRSHMKYN RSSRDISGAT TTT
Length:573
Mass (Da):61,835
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54FDD782DE81E6DB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X68652 mRNA Translation: CAA48611.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S29623

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68652 mRNA Translation: CAA48611.1
PIRiS29623

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Enzyme and pathway databases

UniPathwayiUPA00058;UER00103

Family and domain databases

CDDicd00643, HMG-CoA_reductase_classI, 1 hit
Gene3Di1.10.3270.10, 1 hit
3.30.70.420, 1 hit
3.90.770.10, 1 hit
InterProiView protein in InterPro
IPR002202, HMG_CoA_Rdtase
IPR023074, HMG_CoA_Rdtase_cat_sf
IPR023076, HMG_CoA_Rdtase_CS
IPR004554, HMG_CoA_Rdtase_eu_arc
IPR023282, HMG_CoA_Rdtase_N
IPR009023, HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029, HMG_CoA_Rdtase_sub-bd_dom_sf
PANTHERiPTHR10572, PTHR10572, 1 hit
PfamiView protein in Pfam
PF00368, HMG-CoA_red, 1 hit
PRINTSiPR00071, HMGCOARDTASE
SUPFAMiSSF55035, SSF55035, 1 hit
SSF56542, SSF56542, 1 hit
TIGRFAMsiTIGR00533, HMG_CoA_R_NADP, 1 hit
PROSITEiView protein in PROSITE
PS00066, HMG_COA_REDUCTASE_1, 1 hit
PS00318, HMG_COA_REDUCTASE_2, 1 hit
PS01192, HMG_COA_REDUCTASE_3, 1 hit
PS50065, HMG_COA_REDUCTASE_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ43826_RAPSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q43826
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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