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Protein

Phospholipase D alpha 1

Gene

PLD1

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond. Plays an important role in various cellular processes.

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.

Cofactori

Ca2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei335PROSITE-ProRule annotation1
Active sitei337PROSITE-ProRule annotation1
Active sitei342PROSITE-ProRule annotation1
Active sitei663PROSITE-ProRule annotation1
Active sitei665PROSITE-ProRule annotation1
Active sitei670PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D alpha 1 (EC:3.1.4.4)
Short name:
PLD alpha 1
Alternative name(s):
Choline phosphatase 1
Phosphatidylcholine-hydrolyzing phospholipase D 1
Gene namesi
Name:PLD1
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi113853

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188201 – 812Phospholipase D alpha 1Add BLAST812

Proteomic databases

PaxDbiQ43270
PRIDEiQ43270

Expressioni

Gene expression databases

ExpressionAtlasiQ43270 differential

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi4577.GRMZM2G054559_P01

Structurei

3D structure databases

ProteinModelPortaliQ43270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 114C2Add BLAST114
Domaini330 – 368PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST39
Domaini658 – 685PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST28

Domaini

C2 domain is a calcium-binding fold, and the binding promotes the protein association with membranes. A lower affinity toward calcium can be anticipated for PLD alpha due to the absence of two potential calcium ligands.

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1329 Eukaryota
COG1502 LUCA
HOGENOMiHOG000240112
KOiK01115

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001736 PLipase_D/transphosphatidylase
IPR024632 PLipase_D_C
IPR015679 PLipase_D_fam
IPR011402 PLipase_D_pln
PANTHERiPTHR18896 PTHR18896, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF12357 PLD_C, 1 hit
PF00614 PLDc, 2 hits
PIRSFiPIRSF036470 PLD_plant, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q43270-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQILLHGTL HATIFEAESL SNPHRATGGA PKFIRKLVEG IEDTVGVGKG
60 70 80 90 100
ATKIYATVDL EKARVGRTRM ISNEPVNPRW YESFHIYCAH MAADVIFTVK
110 120 130 140 150
IDNSIGASLI GRAYLAVQDL LGGEEIDKWL EISDENREPV GDSKIHVKLQ
160 170 180 190 200
YFDVGKDRNW ARGVRSTKYP GVPYTFFSQR QGCKVTLYQD AHVPDNFVPR
210 220 230 240 250
IQLADGKNYE PHRCWEDIFD AISKAQHLIY ITGWSVYTEI TLVRDTNRPK
260 270 280 290 300
PGGDVTLGEL LKRKASEGVR VLMLVWDDRT SVGLLKKDGL MATHDEETAN
310 320 330 340 350
YFHGTDVNCV LCPRNPDDSG SFVQDLQIST MFTHHQKIVV VDHEMPNQGS
360 370 380 390 400
QQRRIVSFIG GIDLCDGRYD TQYHSLFRTL DTVHHDDFHQ PNFEGGSIKK
410 420 430 440 450
GGPREPWHDI HSRLEGPIAW DVLYNFEQRW RKQGGKDLLV RLRDLPDIII
460 470 480 490 500
PPSPVMFPED RETWNVQLFR SIDGGAAFGF PETPEEAARA GLVSGKDQII
510 520 530 540 550
DRSIQDAYVN AIRRAKNFIY IENQYFLGSS YGWKPEGIKP EEIGALHLIP
560 570 580 590 600
KELSLKIVSK IEAGERFTVY VVVPMWPEGV PESASVQAIL DWQRRTMEMM
610 620 630 640 650
YTDIAQALEA NGIEANPKDY LTFFCLGNRE VKQEGEYEPE EHPEPDTDYI
660 670 680 690 700
RAQEARRFMI YVHTKMMIVD DEYIIIGSAN INQRSMDGAR DSEIAMGAYQ
710 720 730 740 750
PYHLATRQPA RGQIHGFRMS LWYEHLGMLE DVFQRPESVE CVQKVNEVAE
760 770 780 790 800
KYWDLYSSDD LEQDLPGHLL SYPIGVTADG SVTELPGMEN FPDTRARVLG
810
NKSDYLPPIL TT
Length:812
Mass (Da):92,242
Last modified:November 1, 1997 - v1
Checksum:iD05CB351655BCC61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D73410 mRNA Translation: BAA11135.1
PIRiT03659
RefSeqiNP_001105686.1, NM_001112216.1
UniGeneiZm.95980

Genome annotation databases

GeneIDi542702
KEGGizma:542702

Similar proteinsi

Entry informationi

Entry nameiPLDA1_MAIZE
AccessioniPrimary (citable) accession number: Q43270
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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