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UniProtKB - Q43239 (COMT1_ZINVI)
Protein
Caffeic acid 3-O-methyltransferase
Gene
N/A
Organism
Zinnia violacea (Garden zinnia) (Zinnia elegans)
Status
Functioni
Catalyzes the conversion of caffeic acid to ferulic acid and of 5-hydroxyferulic acid to sinapic acid. The resulting products may subsequently be converted to the corresponding alcohols that are incorporated into lignins.
Catalytic activityi
- EC:2.1.1.68
: phenylpropanoid biosynthesis Pathwayi
This protein is involved in the pathway phenylpropanoid biosynthesis, which is part of Aromatic compound metabolism.View all proteins of this organism that are known to be involved in the pathway phenylpropanoid biosynthesis and in Aromatic compound metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 199 | S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Binding sitei | 222 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 242 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 243 | S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation | 1 | |
Binding sitei | 256 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Active sitei | 260 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- caffeate O-methyltransferase activity Source: UniProtKB-EC
- protein dimerization activity Source: InterPro
GO - Biological processi
- lignin biosynthetic process Source: UniProtKB-KW
- methylation Source: UniProtKB-KW
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Lignin biosynthesis |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
UniPathwayi | UPA00711 |
Names & Taxonomyi
Protein namesi | Recommended name: Caffeic acid 3-O-methyltransferase (EC:2.1.1.68)Short name: CAOMT Short name: COMT Alternative name(s): S-adenosysl-L-methionine:caffeic acid 3-O-methyltransferase |
Organismi | Zinnia violacea (Garden zinnia) (Zinnia elegans) |
Taxonomic identifieri | 34245 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae alliance › Heliantheae › Zinnia |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000063214 | 1 – 354 | Caffeic acid 3-O-methyltransferaseAdd BLAST | 354 |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 121 – 127 | Substrate bindingBy similarity | 7 | |
Regioni | 153 – 171 | Substrate bindingBy similarityAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.PROSITE-ProRule annotation
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR016461, COMT-like IPR001077, O_MeTrfase_dom IPR012967, Plant_MeTrfase_dimerisation IPR029063, SAM-dependent_MTases IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11746, PTHR11746, 1 hit |
Pfami | View protein in Pfam PF08100, Dimerisation, 1 hit PF00891, Methyltransf_2, 1 hit |
PIRSFi | PIRSF005739, O-mtase, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51683, SAM_OMT_II, 1 hit |
i Sequence
Sequence statusi: Complete.
Q43239-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSNQDDQAF LFAMQLASAS VLPMVLKTAI ELDLLETIAK AGPHGSVSSS
60 70 80 90 100
ELVAQLPKVN NPEAPVMIDR ICSLLASYSV LTCTLKETAD GCAERFYGLA
110 120 130 140 150
PVCKFLIKND AGVSLAPLLL MNQDKVLMES WYYLKDPVLD GGIPFNKAYG
160 170 180 190 200
MSAFEYHGKD QRFNKVFNSG MFNHSTMTMK KIVELYNGFS GLKTLVDVGG
210 220 230 240 250
GTGASLNMIT SKHKSLKGIN FDLPHVIADA TTYQGIEHVG GDMFESVPKG
260 270 280 290 300
DAIFMKWILH DWSDAHCLQV LKNCYKSLPE NGKVIVAECI LPEAPDTTPA
310 320 330 340 350
TQNVIHIDVI MLAHNPGGKE RTEKEFEALA KGAGFKGFNK AACALNTWVM
EFCK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19911 mRNA Translation: AAA86718.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19911 mRNA Translation: AAA86718.1 |
3D structure databases
AlphaFoldDBi | Q43239 |
SMRi | Q43239 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00711 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR016461, COMT-like IPR001077, O_MeTrfase_dom IPR012967, Plant_MeTrfase_dimerisation IPR029063, SAM-dependent_MTases IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11746, PTHR11746, 1 hit |
Pfami | View protein in Pfam PF08100, Dimerisation, 1 hit PF00891, Methyltransf_2, 1 hit |
PIRSFi | PIRSF005739, O-mtase, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51683, SAM_OMT_II, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COMT1_ZINVI | |
Accessioni | Q43239Primary (citable) accession number: Q43239 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 11, 2003 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families