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UniProtKB - Q43137 (MTDH1_STYHU)
Protein
Probable mannitol dehydrogenase 1
Gene
CAD1
Organism
Stylosanthes humilis (Townsville stylo) (Astyposanthes humilis)
Status
Functioni
Oxidizes mannitol to mannose. Provides the initial step by which translocated mannitol is committed to central metabolism and, by regulating mannitol pool size, is important in regulating salt tolerance at the cellular level (By similarity).
By similarityCaution
Was originally (Ref. 1) thought to be a cinnamyl-alcohol dehydrogenase.Curated
Catalytic activityi
- EC:1.1.1.255
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 43 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 65 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 96 | Zinc 2By similarity | 1 | |
Metal bindingi | 99 | Zinc 2By similarity | 1 | |
Metal bindingi | 102 | Zinc 2By similarity | 1 | |
Metal bindingi | 110 | Zinc 2By similarity | 1 | |
Metal bindingi | 158 | Zinc 1; catalyticBy similarity | 1 |
GO - Molecular functioni
- mannitol dehydrogenase activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Probable mannitol dehydrogenase 1 (EC:1.1.1.255)Alternative name(s): NAD-dependent mannitol dehydrogenase 1 |
Gene namesi | Name:CAD1 |
Organismi | Stylosanthes humilis (Townsville stylo) (Astyposanthes humilis) |
Taxonomic identifieri | 35628 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Fabales › Fabaceae › Papilionoideae › 50 kb inversion clade › dalbergioids sensu lato › Dalbergieae › Pterocarpus clade › Stylosanthes |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160815 | 1 – 354 | Probable mannitol dehydrogenase 1Add BLAST | 354 |
Family & Domainsi
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH-like_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q43137-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSKAFGWA AKDASGHLSP FHFTRRQNEA DDVTLKILYC GVCHSDLHTV
60 70 80 90 100
KNDWGFTTYP VVPGHEIAGI VTKVGSNVTK FKEGDRVGVG VIVDSCQECE
110 120 130 140 150
CCQQDLESYC PKPVFTYNSP YKGTRTQGGY SDFVVVHQRF VLQFPDNLPL
160 170 180 190 200
DAGAPLLCAG ITVYSPMKYY GMTEPGKHLG VAGLGGLGHV AIKFGKAFGL
210 220 230 240 250
KVTVISSSPN KESEAIDVLG ADSFLLSSDP EKMKAATGTM DYIIDTISAV
260 270 280 290 300
HSLVSLLGLL KLNGKLVTVG LPSKPLQLPI FPLVAGRKLI GGSNFGGLKE
310 320 330 340 350
TQEMLDFCGK HNIAANIELI KMDEINTAIE RLSKADVKYR FVIDVANSLS
SSNM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L36823 mRNA Translation: AAA74882.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L36823 mRNA Translation: AAA74882.1 |
3D structure databases
AlphaFoldDBi | Q43137 |
SMRi | Q43137 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH-like_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MTDH1_STYHU | |
Accessioni | Q43137Primary (citable) accession number: Q43137 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |