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Protein

ATPase 10, plasma membrane-type

Gene

AHA10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The plasma membrane H+ ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3374-aspartylphosphate intermediateBy similarity1
Metal bindingi595MagnesiumBy similarity1
Metal bindingi599MagnesiumBy similarity1

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Source: TAIR
  • ATP binding Source: UniProtKB-KW
  • cation-transporting ATPase activity Source: TAIR
  • metal ion binding Source: UniProtKB-KW
  • proton-exporting ATPase activity, phosphorylative mechanism Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionTranslocase
Biological processHydrogen ion transport, Ion transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G17260-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase 10, plasma membrane-type (EC:7.1.2.1)
Alternative name(s):
Proton pump 10
Gene namesi
Name:AHA10
Ordered Locus Names:At1g17260
ORF Names:F20D23.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G17260
TAIRilocus:2020372 AT1G17260

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 69CytoplasmicSequence analysisAdd BLAST69
Transmembranei70 – 89Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini90 – 101ExtracellularSequence analysisAdd BLAST12
Transmembranei102 – 122Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini123 – 251CytoplasmicSequence analysisAdd BLAST129
Transmembranei252 – 272Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini273 – 281ExtracellularSequence analysis9
Transmembranei282 – 299Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini300 – 650CytoplasmicSequence analysisAdd BLAST351
Transmembranei651 – 672Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini673 – 677ExtracellularSequence analysis5
Transmembranei678 – 700Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini701 – 716CytoplasmicSequence analysisAdd BLAST16
Transmembranei717 – 737Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini738 – 758ExtracellularSequence analysisAdd BLAST21
Transmembranei759 – 779Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini780 – 791CytoplasmicSequence analysisAdd BLAST12
Transmembranei792 – 812Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini813 – 820ExtracellularSequence analysis8
Transmembranei821 – 841Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini842 – 947CytoplasmicSequence analysisAdd BLAST106

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462831 – 947ATPase 10, plasma membrane-typeAdd BLAST947

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei897PhosphoserineBy similarity1
Modified residuei929PhosphoserineBy similarity1
Modified residuei946PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ43128
PRIDEiQ43128

PTM databases

iPTMnetiQ43128

Expressioni

Tissue specificityi

Found primarily in developing seeds.

Gene expression databases

ExpressionAtlasiQ43128 baseline and differential
GenevisibleiQ43128 AT

Interactioni

Protein-protein interaction databases

BioGridi23537, 8 interactors
IntActiQ43128, 4 interactors
STRINGi3702.AT1G17260.1

Structurei

3D structure databases

ProteinModelPortaliQ43128
SMRiQ43128
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0205 Eukaryota
COG0474 LUCA
HOGENOMiHOG000160005
InParanoidiQ43128
KOiK01535
OMAiVDMSQIQ
OrthoDBiEOG0936026Q
PhylomeDBiQ43128

Family and domain databases

CDDicd02076 P-type_ATPase_H, 1 hit
Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006534 P-type_ATPase_IIIA
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01647 ATPase-IIIA_H, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q43128-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEDLDKPLL DPDTFNRKGI DLGILPLEEV FEYLRTSPQG LLSGDAEERL
60 70 80 90 100
KIFGPNRLEE KQENRFVKFL GFMWNPLSWV MEAAALMAIA LANSQSLGPD
110 120 130 140 150
WEDFTGIVCL LLINATISFF EENNAGNAAA ALMARLALKT RVLRDGQWQE
160 170 180 190 200
QDASILVPGD IISIKLGDII PADARLLEGD PLKIDQSVLT GESLPVTKKK
210 220 230 240 250
GEQVFSGSTC KQGEIEAVVI ATGSTTFFGK TARLVDSTDV TGHFQQVLTS
260 270 280 290 300
IGNFCICSIA VGMVLEIIIM FPVQHRSYRI GINNLLVLLI GGIPIAMPTV
310 320 330 340 350
LSVTLAIGSH RLSQQGAITK RMTAIEEMAG MDVLCCDKTG TLTLNSLTVD
360 370 380 390 400
KNLIEVFVDY MDKDTILLLA GRASRLENQD AIDAAIVSML ADPREARANI
410 420 430 440 450
REIHFLPFNP VDKRTAITYI DSDGKWYRAT KGAPEQVLNL CQQKNEIAQR
460 470 480 490 500
VYAIIDRFAE KGLRSLAVAY QEIPEKSNNS PGGPWRFCGL LPLFDPPRHD
510 520 530 540 550
SGETILRALS LGVCVKMITG DQLAIAKETG RRLGMGTNMY PSSSLLGHNN
560 570 580 590 600
DEHEAIPVDE LIEMADGFAG VFPEHKYEIV KILQEMKHVV GMTGDGVNDA
610 620 630 640 650
PALKKADIGI AVADATDAAR SSADIVLTDP GLSVIISAVL TSRAIFQRMR
660 670 680 690 700
NYTVYAVSIT IRIVLGFTLL ALIWEYDFPP FMVLIIAILN DGTIMTISKD
710 720 730 740 750
RVRPSPTPES WKLNQIFATG IVIGTYLALV TVLFYWIIVS TTFFEKHFHV
760 770 780 790 800
KSIANNSEQV SSAMYLQVSI ISQALIFVTR SRGWSFFERP GTLLIFAFIL
810 820 830 840 850
AQLAATLIAV YANISFAKIT GIGWRWAGVI WLYSLIFYIP LDVIKFVFHY
860 870 880 890 900
ALSGEAWNLV LDRKTAFTYK KDYGKDDGSP NVTISQRSRS AEELRGSRSR
910 920 930 940
ASWIAEQTRR RAEIARLLEV HSVSRHLESV IKLKQIDQRM IRAAHTV
Length:947
Mass (Da):104,815
Last modified:January 24, 2001 - v2
Checksum:i1E951DFCC0DA5C24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74033 Genomic DNA Translation: AAB32310.2
AC007651 Genomic DNA Translation: AAD50009.3
CP002684 Genomic DNA Translation: AEE29565.1
PIRiS66367
RefSeqiNP_173169.2, NM_101587.2
UniGeneiAt.51646

Genome annotation databases

EnsemblPlantsiAT1G17260.1; AT1G17260.1; AT1G17260
GeneIDi838297
GrameneiAT1G17260.1; AT1G17260.1; AT1G17260
KEGGiath:AT1G17260

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74033 Genomic DNA Translation: AAB32310.2
AC007651 Genomic DNA Translation: AAD50009.3
CP002684 Genomic DNA Translation: AEE29565.1
PIRiS66367
RefSeqiNP_173169.2, NM_101587.2
UniGeneiAt.51646

3D structure databases

ProteinModelPortaliQ43128
SMRiQ43128
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23537, 8 interactors
IntActiQ43128, 4 interactors
STRINGi3702.AT1G17260.1

PTM databases

iPTMnetiQ43128

Proteomic databases

PaxDbiQ43128
PRIDEiQ43128

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G17260.1; AT1G17260.1; AT1G17260
GeneIDi838297
GrameneiAT1G17260.1; AT1G17260.1; AT1G17260
KEGGiath:AT1G17260

Organism-specific databases

AraportiAT1G17260
TAIRilocus:2020372 AT1G17260

Phylogenomic databases

eggNOGiKOG0205 Eukaryota
COG0474 LUCA
HOGENOMiHOG000160005
InParanoidiQ43128
KOiK01535
OMAiVDMSQIQ
OrthoDBiEOG0936026Q
PhylomeDBiQ43128

Enzyme and pathway databases

BioCyciARA:AT1G17260-MONOMER

Miscellaneous databases

PROiPR:Q43128

Gene expression databases

ExpressionAtlasiQ43128 baseline and differential
GenevisibleiQ43128 AT

Family and domain databases

CDDicd02076 P-type_ATPase_H, 1 hit
Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006534 P-type_ATPase_IIIA
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01647 ATPase-IIIA_H, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPMA10_ARATH
AccessioniPrimary (citable) accession number: Q43128
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 24, 2001
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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