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Protein

Proliferating cell nuclear antigen

Gene
N/A
Organism
Brassica napus (Rape)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi61 – 80Sequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigen
Short name:
PCNA
OrganismiBrassica napus (Rape)
Taxonomic identifieri3708 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeBrassica

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491791 – 263Proliferating cell nuclear antigenAdd BLAST263

Proteomic databases

PRIDEiQ43124

Structurei

3D structure databases

ProteinModelPortaliQ43124
SMRiQ43124
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.Curated

Phylogenomic databases

KOiK04802
OMAiKILRCAG

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
PS00293 PCNA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q43124-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLELRLVQGS LLKKVLESIK DLVNDANFDC STTGFSLQAM DSSHVALVSL
60 70 80 90 100
LLRSEGFEHY RCDRNLSMGM NLGNMSKMLK CAGNDDIITI KADDGGDTVT
110 120 130 140 150
FMFESPKQDK IADFEMKLMD IDSEHLGIPD AEYHSIVRMP SNEFSRICKD
160 170 180 190 200
LSTIGDTVVI SVTKEGVKFS TAGDIGTANI VLRQNTTVDK PEDAIVIEMN
210 220 230 240 250
EPVSLSFALR YMNSFTKATP LSDTVTISLS SELPVVVEYK VAEMGYIRYY
260
LAPKIEEDEE DKA
Length:263
Mass (Da):29,165
Last modified:November 1, 1996 - v1
Checksum:i3C5FB98B4A787A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64617 mRNA Translation: AAB27811.1
PIRiT09523
RefSeqiNP_001303041.1, NM_001316112.1
UniGeneiBna.2144

Genome annotation databases

EnsemblPlantsiCDY06251; CDY06251; GSBRNA2T00122168001
CDY09923; CDY09923; GSBRNA2T00031690001
GeneIDi106420145
GrameneiCDY06251; CDY06251; GSBRNA2T00122168001
CDY09923; CDY09923; GSBRNA2T00031690001
KEGGibna:106420145

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64617 mRNA Translation: AAB27811.1
PIRiT09523
RefSeqiNP_001303041.1, NM_001316112.1
UniGeneiBna.2144

3D structure databases

ProteinModelPortaliQ43124
SMRiQ43124
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ43124

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiCDY06251; CDY06251; GSBRNA2T00122168001
CDY09923; CDY09923; GSBRNA2T00031690001
GeneIDi106420145
GrameneiCDY06251; CDY06251; GSBRNA2T00122168001
CDY09923; CDY09923; GSBRNA2T00031690001
KEGGibna:106420145

Phylogenomic databases

KOiK04802
OMAiKILRCAG

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
PS00293 PCNA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCNA_BRANA
AccessioniPrimary (citable) accession number: Q43124
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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