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Protein

Primary amine oxidase

Gene
N/A
Organism
Pisum sativum (Garden pea)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2.By similarity

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei325Proton acceptorBy similarity1
Active sitei412Schiff-base intermediate with substrate; via topaquinoneBy similarity1
Metal bindingi467Copper; via tele nitrogenCombined sources1 Publication1
Metal bindingi469Copper; via tele nitrogenCombined sources1 Publication1
Metal bindingi476ManganeseCombined sources1 Publication1
Metal bindingi477Manganese; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi478ManganeseCombined sources1 Publication1
Metal bindingi617ManganeseCombined sources1 Publication1
Metal bindingi618Manganese; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi628Copper; via pros nitrogenCombined sources1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandCopper, Manganese, Metal-binding

Enzyme and pathway databases

BRENDAi1.4.3.21 4872
SABIO-RKiQ43077

Names & Taxonomyi

Protein namesi
Recommended name:
Primary amine oxidase (EC:1.4.3.21By similarity)
Alternative name(s):
Amine oxidase [copper-containing]
OrganismiPisum sativum (Garden pea)
Taxonomic identifieri3888 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideae50 kb inversion cladeNPAAA cladeHologaleginaIRL cladeFabeaePisum

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5534

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003568026 – 674Primary amine oxidaseAdd BLAST649

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi156N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi162 ↔ 183Combined sources1 Publication
Disulfide bondi344 ↔ 370Combined sources1 Publication
Glycosylationi389N-linked (GlcNAc...) asparagineCurated1
Modified residuei4122',4',5'-topaquinoneCombined sources1 Publication1

Post-translational modificationi

Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, TPQ

Proteomic databases

PRIDEiQ43077

PTM databases

iPTMnetiQ43077

Interactioni

Subunit structurei

Homodimer.1 Publication

Chemistry databases

BindingDBiQ43077

Structurei

Secondary structure

1674
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ43077
SMRiQ43077
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ43077

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni323 – 334Substrate bindingBy similarityAdd BLAST12
Regioni409 – 414Substrate bindingBy similarity6

Sequence similaritiesi

Belongs to the copper/topaquinone oxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK00276

Family and domain databases

Gene3Di2.70.98.20, 1 hit
InterProiView protein in InterPro
IPR000269 Cu_amine_oxidase
IPR015798 Cu_amine_oxidase_C
IPR036460 Cu_amine_oxidase_C_sf
IPR016182 Cu_amine_oxidase_N-reg
IPR015800 Cu_amine_oxidase_N2
IPR015802 Cu_amine_oxidase_N3
PANTHERiPTHR10638 PTHR10638, 1 hit
PfamiView protein in Pfam
PF01179 Cu_amine_oxid, 1 hit
PF02727 Cu_amine_oxidN2, 1 hit
PF02728 Cu_amine_oxidN3, 1 hit
SUPFAMiSSF49998 SSF49998, 1 hit
SSF54416 SSF54416, 2 hits
PROSITEiView protein in PROSITE
PS01164 COPPER_AMINE_OXID_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q43077-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTTTMRLA LFSVLTLLSF HAVVSVTPLH VQHPLDPLTK EEFLAVQTIV
60 70 80 90 100
QNKYPISNNR LAFHYIGLDD PEKDHVLRYE THPTLVSIPR KIFVVAIINS
110 120 130 140 150
QTHEILINLR IRSIVSDNIH NGYGFPILSV DEQSLAIKLP LKYPPFIDSV
160 170 180 190 200
KKRGLNLSEI VCSSFTMGWF GEEKNVRTVR LDCFMKESTV NIYVRPITGI
210 220 230 240 250
TIVADLDLMK IVEYHDRDIE AVPTAENTEY QVSKQSPPFG PKQHSLTSHQ
260 270 280 290 300
PQGPGFQING HSVSWANWKF HIGFDVRAGI VISLASIYDL EKHKSRRVLY
310 320 330 340 350
KGYISELFVP YQDPTEEFYF KTFFDSGEFG FGLSTVSLIP NRDCPPHAQF
360 370 380 390 400
IDTYVHSANG TPILLKNAIC VFEQYGNIMW RHTENGIPNE SIEESRTEVN
410 420 430 440 450
LIVRTIVTVG NYDNVIDWEF KASGSIKPSI ALSGILEIKG TNIKHKDEIK
460 470 480 490 500
EDLHGKLVSA NSIGIYHDHF YIYYLDFDID GTHNSFEKTS LKTVRIKDGS
510 520 530 540 550
SKRKSYWTTE TQTAKTESDA KITIGLAPAE LVVVNPNIKT AVGNEVGYRL
560 570 580 590 600
IPAIPAHPLL TEDDYPQIRG AFTNYNVWVT AYNRTEKWAG GLYVDHSRGD
610 620 630 640 650
DTLAVWTKQN REIVNKDIVM WHVVGIHHVP AQEDFPIMPL LSTSFELRPT
660 670
NFFERNPVLK TLSPRDVAWP GCSN
Length:674
Mass (Da):76,358
Last modified:November 1, 1996 - v1
Checksum:i30735390071DD18E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39931 Genomic DNA Translation: AAA62490.1
PIRiA57327 C44239

Genome annotation databases

KEGGiag:AAA62490

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39931 Genomic DNA Translation: AAA62490.1
PIRiA57327 C44239

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KSIX-ray2.20A/B31-672[»]
1W2ZX-ray2.24A/B/C/D26-674[»]
ProteinModelPortaliQ43077
SMRiQ43077
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiQ43077
ChEMBLiCHEMBL5534

PTM databases

iPTMnetiQ43077

Proteomic databases

PRIDEiQ43077

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAA62490

Phylogenomic databases

KOiK00276

Enzyme and pathway databases

BRENDAi1.4.3.21 4872
SABIO-RKiQ43077

Miscellaneous databases

EvolutionaryTraceiQ43077

Family and domain databases

Gene3Di2.70.98.20, 1 hit
InterProiView protein in InterPro
IPR000269 Cu_amine_oxidase
IPR015798 Cu_amine_oxidase_C
IPR036460 Cu_amine_oxidase_C_sf
IPR016182 Cu_amine_oxidase_N-reg
IPR015800 Cu_amine_oxidase_N2
IPR015802 Cu_amine_oxidase_N3
PANTHERiPTHR10638 PTHR10638, 1 hit
PfamiView protein in Pfam
PF01179 Cu_amine_oxid, 1 hit
PF02727 Cu_amine_oxidN2, 1 hit
PF02728 Cu_amine_oxidN3, 1 hit
SUPFAMiSSF49998 SSF49998, 1 hit
SSF54416 SSF54416, 2 hits
PROSITEiView protein in PROSITE
PS01164 COPPER_AMINE_OXID_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAMO_PEA
AccessioniPrimary (citable) accession number: Q43077
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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