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UniProtKB - Q42946 (HEM6_TOBAC)
Protein
Oxygen-dependent coproporphyrinogen-III oxidase, chloroplastic
Gene
CPX
Organism
Nicotiana tabacum (Common tobacco)
Status
Functioni
Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).
By similarityCatalytic activityi
- EC:1.3.3.3
: protoporphyrin-IX biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes protoporphyrinogen-IX from coproporphyrinogen-III (O2 route). This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoporphyrinogen-IX from coproporphyrinogen-III (O2 route), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 185 | SubstrateBy similarity | 1 | |
Active sitei | 199 | Proton donorBy similarity | 1 | |
Sitei | 272 | Important for dimerizationBy similarity | 1 |
GO - Molecular functioni
- coproporphyrinogen oxidase activity Source: GO_Central
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- chlorophyll biosynthetic process Source: UniProtKB-KW
- protoporphyrinogen IX biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Chlorophyll biosynthesis, Heme biosynthesis, Porphyrin biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00251;UER00322 |
Names & Taxonomyi
Protein namesi | Recommended name: Oxygen-dependent coproporphyrinogen-III oxidase, chloroplastic (EC:1.3.3.3)Short name: Coprogen oxidase Short name: Coproporphyrinogenase |
Gene namesi | Name:CPX |
Organismi | Nicotiana tabacum (Common tobacco) |
Taxonomic identifieri | 4097 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana |
Proteomesi |
|
Subcellular locationi
Chloroplast
- chloroplast Curated
Chloroplast
- chloroplast Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Chloroplast, PlastidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | ChloroplastSequence analysis | ||
ChainiPRO_0000006034 | ? – 397 | Oxygen-dependent coproporphyrinogen-III oxidase, chloroplastic |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 4097.Q42946 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 76 – 95 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 135 – 144 | Important for dimerizationBy similarity | 10 | |
Regioni | 201 – 203 | Substrate bindingBy similarity | 3 | |
Regioni | 337 – 372 | Important for dimerizationBy similarityAdd BLAST | 36 | |
Regioni | 355 – 360 | Substrate bindingBy similarity | 6 |
Sequence similaritiesi
Belongs to the aerobic coproporphyrinogen-III oxidase family.Curated
Keywords - Domaini
Transit peptideFamily and domain databases
Gene3Di | 3.40.1500.10, 1 hit |
InterProi | View protein in InterPro IPR001260, Coprogen_oxidase_aer IPR036406, Coprogen_oxidase_aer_sf IPR018375, Coprogen_oxidase_CS |
PANTHERi | PTHR10755, PTHR10755, 1 hit |
Pfami | View protein in Pfam PF01218, Coprogen_oxidas, 1 hit |
PIRSFi | PIRSF000166, Coproporphyri_ox, 1 hit |
PRINTSi | PR00073, COPRGNOXDASE |
SUPFAMi | SSF102886, SSF102886, 1 hit |
PROSITEi | View protein in PROSITE PS01021, COPROGEN_OXIDASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q42946-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTPILSSAS CSWTPTSQFP HSWHSSPSFL TKPLNLPFTE SYKTAKRPTP
60 70 80 90 100
NYSFKVQAMI EKEVAVSHKP DAFLRESDMG SNVTSNSSSV RGRFEKMRRE
110 120 130 140 150
AQDSVCLAIE KADGGAKFKE DVWSRPGGGG GHSSVLQDGA VFEKAGVNVS
160 170 180 190 200
VVYGVMPPEA YRAARPTDNG NVKPGPIPFF AAGVSSVLHP KNPFAPTLHF
210 220 230 240 250
NYRYFETDAP KDAPGAPRQW WFGGGTDFTP AYIFEEDVKH FHSVQKAACD
260 270 280 290 300
KFDASFYPRF KKWCVDYFYI KHRDERRGLG GIFFDDFNDY DQEMLLSFST
310 320 330 340 350
ECANSVIPAY IPIVEKRKDT PFTDKHKAWQ QLRRGRYVEF NLVYDRGTTF
360 370 380 390
GLKTGGRIES ILVSLPLTAR WEYDHKPEEG TEEWKLLDAC INPKEWI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82831 mRNA Translation: CAA58038.1 |
PIRi | T02929 |
RefSeqi | NP_001312882.1, NM_001325953.1 |
Genome annotation databases
GeneIDi | 107815524 |
KEGGi | nta:107815524 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82831 mRNA Translation: CAA58038.1 |
PIRi | T02929 |
RefSeqi | NP_001312882.1, NM_001325953.1 |
3D structure databases
SMRi | Q42946 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4097.Q42946 |
Genome annotation databases
GeneIDi | 107815524 |
KEGGi | nta:107815524 |
Enzyme and pathway databases
UniPathwayi | UPA00251;UER00322 |
Family and domain databases
Gene3Di | 3.40.1500.10, 1 hit |
InterProi | View protein in InterPro IPR001260, Coprogen_oxidase_aer IPR036406, Coprogen_oxidase_aer_sf IPR018375, Coprogen_oxidase_CS |
PANTHERi | PTHR10755, PTHR10755, 1 hit |
Pfami | View protein in Pfam PF01218, Coprogen_oxidas, 1 hit |
PIRSFi | PIRSF000166, Coproporphyri_ox, 1 hit |
PRINTSi | PR00073, COPRGNOXDASE |
SUPFAMi | SSF102886, SSF102886, 1 hit |
PROSITEi | View protein in PROSITE PS01021, COPROGEN_OXIDASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HEM6_TOBAC | |
Accessioni | Q42946Primary (citable) accession number: Q42946 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families