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UniProtKB - Q42840 (HEM6_HORVU)
Protein
Oxygen-dependent coproporphyrinogen-III oxidase, chloroplastic
Gene
CPX
Organism
Hordeum vulgare (Barley)
Status
Functioni
Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).
By similarityCatalytic activityi
- EC:1.3.3.3
: protoporphyrin-IX biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes protoporphyrinogen-IX from coproporphyrinogen-III (O2 route). This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoporphyrinogen-IX from coproporphyrinogen-III (O2 route), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 179 | SubstrateBy similarity | 1 | |
Active sitei | 193 | Proton donorBy similarity | 1 | |
Sitei | 266 | Important for dimerizationBy similarity | 1 |
GO - Molecular functioni
- coproporphyrinogen oxidase activity Source: UniProtKB-EC
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- chlorophyll biosynthetic process Source: UniProtKB-KW
- protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Chlorophyll biosynthesis, Heme biosynthesis, Porphyrin biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00251;UER00322 |
Names & Taxonomyi
Protein namesi | Recommended name: Oxygen-dependent coproporphyrinogen-III oxidase, chloroplastic (EC:1.3.3.3)Short name: Coprogen oxidase Short name: Coproporphyrinogenase |
Gene namesi | Name:CPX |
Organismi | Hordeum vulgare (Barley) |
Taxonomic identifieri | 4513 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Pooideae › Triticodae › Triticeae › Hordeinae › Hordeum |
Subcellular locationi
Chloroplast
- chloroplast Curated
Chloroplast
- chloroplast Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chloroplast, PlastidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | ChloroplastSequence analysis | ||
ChainiPRO_0000006032 | ? – 391 | Oxygen-dependent coproporphyrinogen-III oxidase, chloroplastic |
Proteomic databases
PRIDEi | Q42840 |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 34 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 125 – 134 | Important for dimerizationBy similarity | 10 | |
Regioni | 195 – 197 | Substrate bindingBy similarity | 3 | |
Regioni | 331 – 366 | Important for dimerizationBy similarityAdd BLAST | 36 | |
Regioni | 349 – 354 | Substrate bindingBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 15 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the aerobic coproporphyrinogen-III oxidase family.Curated
Keywords - Domaini
Transit peptideFamily and domain databases
Gene3Di | 3.40.1500.10, 1 hit |
InterProi | View protein in InterPro IPR001260, Coprogen_oxidase_aer IPR036406, Coprogen_oxidase_aer_sf IPR018375, Coprogen_oxidase_CS |
PANTHERi | PTHR10755, PTHR10755, 1 hit |
Pfami | View protein in Pfam PF01218, Coprogen_oxidas, 1 hit |
PIRSFi | PIRSF000166, Coproporphyri_ox, 1 hit |
PRINTSi | PR00073, COPRGNOXDASE |
SUPFAMi | SSF102886, SSF102886, 1 hit |
PROSITEi | View protein in PROSITE PS01021, COPROGEN_OXIDASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q42840-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSLLTTPS QTLAPNPAAA RARRSSPAAA QVSFSSPLLP GRRALRCARP
60 70 80 90 100
VAIEKEVPEK EAPTTFLRED GSGAGSGSVR ERFEGMIRRV QGEICAALEE
110 120 130 140 150
ADGSGKRFVE DVWSRPGGVC VHSRVLQDGN VFEKAGVNVS AVIGVCPRSA
160 170 180 190 200
YRAAKGAAKN GAADGHKAGP VPFFSAGISS VLHPKNPFAP TLHFNYRYFE
210 220 230 240 250
TDAPKDVPGA PRSWWFGGGT DLTPSYLIEE DVKHFHSVQK QTCDKFDPSF
260 270 280 290 300
YPRFKKWCDD YFYIKHRNER RGLGGIFFDD LNDYDQDMLL NFATECAGSV
310 320 330 340 350
IPAYIPIIER RKDTPFNEEQ KAWQQVRRGR YVEFNLVYDR GTTFGLKTGG
360 370 380 390
RIESILVSLP LTARWEYDHK PEEGSEEWKL LDACINPKEW L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82830 mRNA Translation: CAA58037.1 |
PIRi | T04486 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82830 mRNA Translation: CAA58037.1 |
PIRi | T04486 |
3D structure databases
AlphaFoldDBi | Q42840 |
SMRi | Q42840 |
ModBasei | Search... |
Chemistry databases
ChEMBLi | CHEMBL2366495 |
Proteomic databases
PRIDEi | Q42840 |
Enzyme and pathway databases
UniPathwayi | UPA00251;UER00322 |
Gene expression databases
ExpressionAtlasi | Q42840, baseline and differential |
Family and domain databases
Gene3Di | 3.40.1500.10, 1 hit |
InterProi | View protein in InterPro IPR001260, Coprogen_oxidase_aer IPR036406, Coprogen_oxidase_aer_sf IPR018375, Coprogen_oxidase_CS |
PANTHERi | PTHR10755, PTHR10755, 1 hit |
Pfami | View protein in Pfam PF01218, Coprogen_oxidas, 1 hit |
PIRSFi | PIRSF000166, Coproporphyri_ox, 1 hit |
PRINTSi | PR00073, COPRGNOXDASE |
SUPFAMi | SSF102886, SSF102886, 1 hit |
PROSITEi | View protein in PROSITE PS01021, COPROGEN_OXIDASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HEM6_HORVU | |
Accessioni | Q42840Primary (citable) accession number: Q42840 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families