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UniProtKB - Q42541 (UBC13_ARATH)
Protein
Ubiquitin-conjugating enzyme E2 13
Gene
UBC13
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation.
1 PublicationCaution
This protein has been named UBC13 according to the nomenclature proposed in PubMed:16339806, but it is not the same as the UBC13 described in several publications that correspond to the protein named UBC35 in our nomenclature.Curated
Catalytic activityi
- S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation EC:2.3.2.23
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 89 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ubiquitin conjugating enzyme activity Source: GO_Central
- ubiquitin-protein transferase activity Source: TAIR
GO - Biological processi
- protein polyubiquitination Source: GO_Central
- ubiquitin-dependent protein catabolic process Source: TAIR
Keywordsi
Molecular function | Transferase |
Biological process | Ubl conjugation pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-conjugating enzyme E2 13 (EC:2.3.2.23)Alternative name(s): E2 ubiquitin-conjugating enzyme 13 Ubiquitin carrier protein 13 Ubiquitin-protein ligase 13 |
Gene namesi | Name:UBC13 Ordered Locus Names:At3g46460 ORF Names:F18L15.180 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G46460 |
TAIRi | locus:2078231, AT3G46460 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082587 | 1 – 166 | Ubiquitin-conjugating enzyme E2 13Add BLAST | 166 |
Proteomic databases
PaxDbi | Q42541 |
PRIDEi | Q42541 |
ProteomicsDBi | 228650 |
Expressioni
Inductioni
Up-regulated by syringolin, a cell death-inducing chemical.1 Publication
Gene expression databases
ExpressionAtlasi | Q42541, baseline and differential |
Genevisiblei | Q42541, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 9116, 1 interactor |
STRINGi | 3702.AT3G46460.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 164 | UBC corePROSITE-ProRule annotationAdd BLAST | 161 |
Sequence similaritiesi
Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0425, Eukaryota |
HOGENOMi | CLU_030988_10_1_1 |
InParanoidi | Q42541 |
OMAi | KMWRENR |
OrthoDBi | 1317014at2759 |
PhylomeDBi | Q42541 |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBC_1, 1 hit PS50127, UBC_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q42541-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSQACLLLQ KQLKDLCKHP VDGFSAGLVD EKNIFEWSVT IIGPPDTLYE
60 70 80 90 100
GGFFYAIMSF PQNYPNSPPT VRFTSDIWHP NVYPDGRVCI SILHPPGDDP
110 120 130 140 150
SGYELASERW TPVHTVESIM LSIISMLSGP NDESPANVEA AKEWREKRDE
160
FKKKVSRCVR KSQEMF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1I9LLI9 | A0A1I9LLI9_ARATH | Ubiquitin-conjugating enzyme 13 | UBC13 At3g46460 | 124 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33758 Genomic DNA Translation: AAC49322.1 DQ027027 mRNA Translation: AAY44853.1 AL133298 Genomic DNA Translation: CAB62037.1 CP002686 Genomic DNA Translation: AEE78162.1 AY050368 mRNA Translation: AAK91385.1 AY094040 mRNA Translation: AAM16196.1 |
PIRi | T45703 |
RefSeqi | NP_566884.1, NM_114513.6 |
Genome annotation databases
EnsemblPlantsi | AT3G46460.1; AT3G46460.1; AT3G46460 |
GeneIDi | 823796 |
Gramenei | AT3G46460.1; AT3G46460.1; AT3G46460 |
KEGGi | ath:AT3G46460 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33758 Genomic DNA Translation: AAC49322.1 DQ027027 mRNA Translation: AAY44853.1 AL133298 Genomic DNA Translation: CAB62037.1 CP002686 Genomic DNA Translation: AEE78162.1 AY050368 mRNA Translation: AAK91385.1 AY094040 mRNA Translation: AAM16196.1 |
PIRi | T45703 |
RefSeqi | NP_566884.1, NM_114513.6 |
3D structure databases
AlphaFoldDBi | Q42541 |
SMRi | Q42541 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 9116, 1 interactor |
STRINGi | 3702.AT3G46460.1 |
Proteomic databases
PaxDbi | Q42541 |
PRIDEi | Q42541 |
ProteomicsDBi | 228650 |
Genome annotation databases
EnsemblPlantsi | AT3G46460.1; AT3G46460.1; AT3G46460 |
GeneIDi | 823796 |
Gramenei | AT3G46460.1; AT3G46460.1; AT3G46460 |
KEGGi | ath:AT3G46460 |
Organism-specific databases
Araporti | AT3G46460 |
TAIRi | locus:2078231, AT3G46460 |
Phylogenomic databases
eggNOGi | KOG0425, Eukaryota |
HOGENOMi | CLU_030988_10_1_1 |
InParanoidi | Q42541 |
OMAi | KMWRENR |
OrthoDBi | 1317014at2759 |
PhylomeDBi | Q42541 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Miscellaneous databases
PROi | PR:Q42541 |
Gene expression databases
ExpressionAtlasi | Q42541, baseline and differential |
Genevisiblei | Q42541, AT |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBC_1, 1 hit PS50127, UBC_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UBC13_ARATH | |
Accessioni | Q42541Primary (citable) accession number: Q42541 Secondary accession number(s): Q4TYZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 23, 2003 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families