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UniProtKB - Q42497 (Q42497_CHLVU)

Entry version 123 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Nitrate reductase

Gene
N/A
Organism
Chlorella vulgaris (Green alga)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.UniRule annotationARBA annotation

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi163MolybdenumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseARBA annotation
Biological processNitrate assimilationUniRule annotationARBA annotation
LigandFADARBA annotation, Flavoprotein, HemeARBA annotation, Iron, Metal-binding, MolybdenumUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nitrate reductaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlorella vulgaris (Green alga)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3077 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Chlorophyta › core chlorophytes › Trebouxiophyceae › Chlorellales › Chlorellaceae › Chlorella clade › Chlorella

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

ARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q42497

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini502 – 577Cytochrome b5 heme-bindingInterPro annotationAdd BLAST76
Domaini623 – 735FAD-binding FR-typeInterPro annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 57DisorderedSequence analysisAdd BLAST57

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nitrate reductase family.UniRule annotationARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.120.10, 1 hit
3.40.50.80, 1 hit
3.90.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001834, CBR-like
IPR008333, Cbr1-like_FAD-bd_dom
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR036400, Cyt_B5-like_heme/steroid_sf
IPR018506, Cyt_B5_heme-BS
IPR017927, FAD-bd_FR_type
IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR039261, FNR_nucleotide-bd
IPR014756, Ig_E-set
IPR005066, MoCF_OxRdtse_dimer
IPR008335, Mopterin_OxRdtase_euk
IPR012137, Nitr_rd_NADH
IPR001433, OxRdtase_FAD/NAD-bd
IPR000572, OxRdtase_Mopterin-bd_dom
IPR036374, OxRdtase_Mopterin-bd_sf
IPR017938, Riboflavin_synthase-like_b-brl

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00173, Cyt-b5, 1 hit
PF00970, FAD_binding_6, 1 hit
PF03404, Mo-co_dimer, 1 hit
PF00175, NAD_binding_1, 1 hit
PF00174, Oxidored_molyb, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000233, Nitr_rd_NADH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00406, CYTB5RDTASE
PR00363, CYTOCHROMEB5
PR00407, EUMOPTERIN
PR00371, FPNCR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01117, Cyt-b5, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52343, SSF52343, 1 hit
SSF55856, SSF55856, 1 hit
SSF56524, SSF56524, 1 hit
SSF63380, SSF63380, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00191, CYTOCHROME_B5_1, 1 hit
PS50255, CYTOCHROME_B5_2, 1 hit
PS51384, FAD_FR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q42497-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVLLAGEDS AHGSGSAGAA MKANGYSTEA SAASPQAPAA ECGKAPVEEP 
        60         70         80         90        100
LQPGTDEYKL HLPVTEVLDA DKGTKDEWIP RHPDLVRLTG RHPFNVEPIP 
       110        120        130        140        150
SRLFESYITP PSLHYVRNHG AVPQIKWEEH RLAVNGLVSA PTTFTMDDIL 
       160        170        180        190        200
AMPSVDVTCT LTCAGNRRKE ENMVKQTIGF NWGPSGTGCS TWTGVRVSDL 
       210        220        230        240        250
LQRCGMKMPK EGARHVCFRG PKGELPKGDD GSYGTSVTWV KAMDPASDVI 
       260        270        280        290        300
LAYKQNGRLL TPDHGYPLRL IIPGYIGGRM IKWLEEITVT EVESQNYYHF 
       310        320        330        340        350
HDNRVLPSHV DEALANSEGW WYKPDFIIND LNVQSAIGYP AHEEVVPLAA 
       360        370        380        390        400
GTYAVRGYAY CGNGNKIIRC EVSLDDGKSW RLGSVTHEGQ PTEYGKHWGW 
       410        420        430        440        450
VWWSLEVPIA ELLTTPEIIC RAWDSSMNTQ PNTFTWNVMG MMNNCSYRVK 
       460        470        480        490        500
IHPRQTTDGR FALQFEHPTI AGPTVGGWMN RAEDVAAAAA VTVAPPPAPA 
       510        520        530        540        550
GAKSFTMAEV ETHTTMESAW FVVDGKVYDA TPFLKDHPGG ADSILLVAGT 
       560        570        580        590        600
DATDEFNAIH SLKAKKQLLE YYIGELAEEG QEAAAPAPAT PAPAAAIGTA 
       610        620        630        640        650
VPVANGAAPA AAAPEELVAL NPRKRQSFKL IEKEALSHNT RRFRFALQSP 
       660        670        680        690        700
QHRFGLPVGK HVFLYAKVDG ELVMRAYTPS SSDDQLGYFE LVVKIYFANQ 
       710        720        730        740        750
HPRFPEGGKM SQYLEGMAIG DFMEVKGPLG HVHYKGRGSY TLDGTPHSAS 
       760        770        780        790        800
RISMIAGGTG ITPMLQVIKA VLKDPKDTTQ LSLLYANVSP DDILLREELD 
       810        820        830        840        850
ALAAKHDNFS VWYTVDKADE GWPFSTGFIN EEMVKERLFP AGDDTICCLC 
       860        870 
GPPPMIKFAC LPNLEKLGYK PEQCIQF
Length:877
Mass (Da):96,011
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i09248C1B3337371C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U39930 mRNA Translation: AAC49459.1
U39931 Genomic DNA Translation: AAC49460.1

Protein sequence database of the Protein Information Resource

More...PIRi		S72541

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39930 mRNA Translation: AAC49459.1
U39931 Genomic DNA Translation: AAC49460.1
PIRiS72541

3D structure databases

SMRiQ42497
ModBaseiSearch...

Family and domain databases

Gene3Di3.10.120.10, 1 hit
3.40.50.80, 1 hit
3.90.420.10, 1 hit
InterProiView protein in InterPro
IPR001834, CBR-like
IPR008333, Cbr1-like_FAD-bd_dom
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR036400, Cyt_B5-like_heme/steroid_sf
IPR018506, Cyt_B5_heme-BS
IPR017927, FAD-bd_FR_type
IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR039261, FNR_nucleotide-bd
IPR014756, Ig_E-set
IPR005066, MoCF_OxRdtse_dimer
IPR008335, Mopterin_OxRdtase_euk
IPR012137, Nitr_rd_NADH
IPR001433, OxRdtase_FAD/NAD-bd
IPR000572, OxRdtase_Mopterin-bd_dom
IPR036374, OxRdtase_Mopterin-bd_sf
IPR017938, Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00173, Cyt-b5, 1 hit
PF00970, FAD_binding_6, 1 hit
PF03404, Mo-co_dimer, 1 hit
PF00175, NAD_binding_1, 1 hit
PF00174, Oxidored_molyb, 1 hit
PIRSFiPIRSF000233, Nitr_rd_NADH, 1 hit
PRINTSiPR00406, CYTB5RDTASE
PR00363, CYTOCHROMEB5
PR00407, EUMOPTERIN
PR00371, FPNCR
SMARTiView protein in SMART
SM01117, Cyt-b5, 1 hit
SUPFAMiSSF52343, SSF52343, 1 hit
SSF55856, SSF55856, 1 hit
SSF56524, SSF56524, 1 hit
SSF63380, SSF63380, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00191, CYTOCHROME_B5_1, 1 hit
PS50255, CYTOCHROME_B5_2, 1 hit
PS51384, FAD_FR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ42497_CHLVU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q42497
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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