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Protein

Thioredoxin H3

Gene

TRX3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thiol-disulfide oxidoreductase that possesses disulfide reductase and insulin disulfide bonds reducing activities. Heat shock causes oligomerization and formation of high molecular weight (HMW) complexes with concomitant functional switching from a disulfide reductase to chaperone.2 Publications

Caution

The active site contains a CPPC motif wich differs from the conserved CGPC motif.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei39NucleophileSequence analysis1
Active sitei42NucleophileSequence analysis1

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: GO_Central
  • cellular response to oxidative stress Source: GO_Central
  • defense response to fungus Source: TAIR
  • glycerol ether metabolic process Source: InterPro
  • heat acclimation Source: UniProtKB
  • protein complex oligomerization Source: UniProtKB
  • protein folding Source: UniProtKB
  • response to cytokinin Source: TAIR
  • response to heat Source: UniProtKB
  • response to microbial phytotoxin Source: TAIR

Keywordsi

Molecular functionChaperone
Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin H3
Short name:
AtTrxh3
Alternative name(s):
Thioredoxin 3
Short name:
AtTRX3
Gene namesi
Name:TRX3
Ordered Locus Names:At5g42980
ORF Names:MBD2.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G42980
TAIRilocus:2159971 AT5G42980

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

High sensitivity to heat shock.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39C → S: Loss of disulfide reductase activity. 1 Publication1
Mutagenesisi42C → S: Loss of disulfide reductase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001200482 – 118Thioredoxin H3Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Disulfide bondi39 ↔ 42Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiQ42403
PRIDEiQ42403

PTM databases

iPTMnetiQ42403
SwissPalmiQ42403

Expressioni

Gene expression databases

ExpressionAtlasiQ42403 baseline and differential
GenevisibleiQ42403 AT

Interactioni

Subunit structurei

Interacts with FBA5 and FBA8 (PubMed:15352244). Interacts with FBA6 (PubMed:21782461).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi19563, 19 interactors
DIPiDIP-32720N
IntActiQ42403, 71 interactors
STRINGi3702.AT5G42980.1

Structurei

3D structure databases

ProteinModelPortaliQ42403
SMRiQ42403
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 113ThioredoxinPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0907 Eukaryota
COG0526 LUCA
HOGENOMiHOG000292977
InParanoidiQ42403
KOiK03671
OMAiHITSNDE
OrthoDBiEOG09360XJ5
PhylomeDBiQ42403

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PANTHERiPTHR10438 PTHR10438, 1 hit
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
PIRSFiPIRSF000077 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEGEVIAC HTVEDWTEKL KAANESKKLI VIDFTATWCP PCRFIAPVFA
60 70 80 90 100
DLAKKHLDVV FFKVDVDELN TVAEEFKVQA MPTFIFMKEG EIKETVVGAA
110
KEEIIANLEK HKTVVAAA
Length:118
Mass (Da):13,109
Last modified:November 1, 1996 - v1
Checksum:i7AFCE291C3EB8FE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35474 mRNA Translation: CAA84611.1
U35640 Genomic DNA Translation: AAC49351.1
AB008264 Genomic DNA Translation: BAB09200.1
CP002688 Genomic DNA Translation: AED94897.1
AY059870 mRNA Translation: AAL24352.1
AY065098 mRNA Translation: AAL38274.1
AY093318 mRNA Translation: AAM13317.1
AY114566 mRNA Translation: AAM47885.1
AY085117 mRNA Translation: AAM61671.1
Z35335 mRNA Translation: CAA84560.1
PIRiS58118
RefSeqiNP_199112.1, NM_123664.4
UniGeneiAt.24175

Genome annotation databases

EnsemblPlantsiAT5G42980.1; AT5G42980.1; AT5G42980
GeneIDi834313
GrameneiAT5G42980.1; AT5G42980.1; AT5G42980
KEGGiath:AT5G42980

Similar proteinsi

Entry informationi

Entry nameiTRXH3_ARATH
AccessioniPrimary (citable) accession number: Q42403
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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